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Doctor insights on: Causes Of Monoclonal Gammopathy

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What causes monoclonal paraproteinemia?

What causes monoclonal paraproteinemia?

Excess of Plasma cel: Plasma cells in our bone marrow make antibodies. Sometimes they become overly active/reactive and produce abnormal proteins called paraproteins. Most such protein production is benign and not uncommon in older folks. Sometimes it is excessive(more than 1gram/day) then we get concerned about a condition called multiple myeloma (paraproteins over 3 grams). ...Read more

Dr. Patricia Foster
31 doctors shared insights

Gammopathy (Definition)

A gammopathy is an abnormal gammaglobulin or gammaglobulin level. A monoclonal gammopathy is a single abnormal protein that can indicate a bone marrow cancer called multiple myeloma, or a lymphoma. Further evaluation is required to determine if a monoclonal gammopathy ...Read more


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What's monoclonal gammopathy of undetermined significance?

What's monoclonal gammopathy of undetermined significance?

MGUS: Is a common precancerous condition affecting people 50 years of age and older. It was first described by mayo clinic researchers in 1978 and is characterized by the presence of an abnormal protein in the blood called a (monoclonal) protein or m protein.Mgus has a small risk (1 percent each year) of progressing to a blood cancer called multiple myeloma or a related condition. ...Read more

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What is monoclonal gammopathy of undetermined significance (mgus)?

Blood & urine tests: Mgus is the presence of an abnormal protrein in the blood made by a type of white blood cell called a plasmacyte. In most cases, it is at a low level and is something that just has to be followed. However, it can be the precursor of the disease called multiple myeloma and as such a hematologist or medical oncologist will order tests to rule this out which may include blood, urine and simple x-rays. ...Read more

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What's monoclonal lymphocytes of undetermined significance?

What's monoclonal lymphocytes of undetermined significance?

Excellent question.: Monoclonal lymphocytes mean that a single lymphocyte has been stimulated to divide and create an expanded number of identical daughter cells. There are enough of them to be identified by a test (flow cytometry) but not enough to meet criteria for a leukemia. There may be a genetic predisposition. This is a benign condition, but there is uncertainty as to whether it might progress to malignancy. ...Read more

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Causes of hypergammaglobulinemia?

Causes of hypergammaglobulinemia?

Mono or Polyclonal: High levels of immunoglobulins (hypergammaglobulinemia) can be monoclonal (specific) - due to malignant proliferation of plasma cells or lymphocytes as in myeloma or waldenstrom's macroglobulinemia. Polyclonal (many types) hypergammaglobulinemia is a benign condition due to infection, inflammation causing non-specific gamma globulin production such as in hepatitis, immune and allergic disorders. ...Read more

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Describe polyclonal and monoclonal antibody production?

Describe polyclonal and monoclonal antibody production?

Cells vs, animals: A monoclonal antibody is produced by in-vitro manipulation by expoanding a single cell making a desired antibody. Polyclonal antibodies are usually derived from immunizing an animal and colletcting its blood/serum containing the antibody. Polyclonal antibodies are a mixture of a large number of different cells. ...Read more

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In protein's electrophoresis Is polyclonal gammopathy alway pathological? Thanks

Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, What is total gamma globulin level? If it is more than 2.0 gm/dL it needs to be evaluated. There are many causes of polyclonal gammopathy., and some of those are serious. ...Read more

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What can cause monoclonal gammopathy?

What can cause monoclonal gammopathy?

Mayo Clinic say: Plasma cells are a type of white blood cell. They are found in your bone marrow. Plasma cells produce some of the antibodies that help your body fight infection. Monoclonal gammopathy of undetermined significance occurs when plasma cells in your bone marrow produce an abnormal protein called monoclonal protein (m protein). ...Read more

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What is the significance of low Igm levels in smoldering Multiple Myeloma?

What is the significance of low Igm levels in smoldering Multiple Myeloma?

Depends: If you have M protein from another class of immunoglobulin, then the cells producing this M protein would crowd out the other immunoglobulin producing cells in the bone marrow leading to a lower level of what that cell would ordinarily produce. Some Multiple myeloma cases are of no medical significance but needs to be followed. Many myeloma patients are prone to bacterial infections. ...Read more

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What is the definition or description of: monoclonal gammopathy of undetermined significance?

What is the definition or description of: monoclonal gammopathy of undetermined significance?

A monoclonal: Gammopathy is an elevation in a specific type of immune protein in the blood. The work-up includes tests of urine protein, bones and blood production. If no serious associated disease is found then the clinical finding is called mgus. The patient is followed over time to see if the gammopathy becomes "significant." some patients declare themselves later with multiple myemoma or lymphoma. ...Read more

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Is a tiny IgM kappa monoclonal protein migrating in beta2 region considered specific for waldenström's macroglobulinemia irrespective of size?

No. MGUS: Mgus = monoclonal gammopathy of unknown significance. Igm is associated more with waldenstrom's macroglobulinemia (vs igg, iga, igd, ige with multiple myeloma). More info on background is here: http://bloodjournal.Hematologylibrary.Org/content/109/12/5096.Full" rel="nofollow" ta. ...Read more

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Is mononuclueosis associated at all with monoclonal gammopathy?

Is mononuclueosis associated at all with monoclonal gammopathy?

No: Ebv infection, the cause of mononucleosis is not usually related to monoclonal gammopathy. Ebv induced lymphoma may produce monoclonal gammopathy, but that would be an uncommon situation. ...Read more

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What are causes of elevated igm?

What are causes of elevated igm?

IgM: Igm is our first defense against bacteria, so if you have an active infection it can be the cause of this elevation. A chronically elevated igm may indicate an immunodeficiency. An immunologist can help you make the diagnosis. In rare cases it can be a malignancy. ...Read more

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What are possible causes of highly elevated ImM levels with low ImG levels with no monoclonal gammopathy present?

May not be a problem: This may depend on your genetic background and not be a medical problem. We would need an explanation of your problems, blurred vision, night sweats. Why are you on opiates ...Read more

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Can monoclonal gammopathy cause osteomyelitis?

Can monoclonal gammopathy cause osteomyelitis?

Not realy: It's estimated that between 10 and 25 percent of people with monoclonal gammopathy of undetermined significance develop a more serious condition, such as multiple myeloma or other cancers or blood disorders. Other complications include fractures and blood clots. ...Read more

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Immunifixation identifies m spike as IGg Kappa polyclonal gamma globulin to consist mainly of IGg Kappa n Lamda with fair amounts of Iga means what?

Immunifixation identifies m spike as IGg Kappa polyclonal gamma globulin to consist mainly of IGg Kappa n Lamda with fair amounts of Iga means what?

?? Chronic Infection: M spike of polyclonal IgG (kappa & lambda) globulin mostly suggest chronic infectious or inflammatory process & rarely hematologic malignancies. You need a complete work up for ch. liver disease, hepatitis B/C, ch.bacterial, viral & fungal infection, HIV, autoimmune diseases & if negative then evaluate for hematological disorder. CHECK FOR Ch. INFECTION & HEPATITIS. Update me with your result. ...Read more

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What are the cuases of elevated anticardiolipin antibodies?

Auto-immunity: Anticardiolipin antibodies are commonly present in systemic lupus and related disorders. These antibodies are also present due to syphilis. See this site for more info. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc95774/. ...Read more

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What is monoclonal gammopathy?

A tumor type: There are various grades of monoclonal gammopathy. The three types, in increasing order of malignancy are monoclonal gammapathy of undetermined significance (MGUS), smoldering myeloma and the last one, which is a cancer, multiple myeloma. ...Read more

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What is the significance of a low Igm level in smoldering multiple myeloma?

Part of the disease: Whenever you have smoldering myeloma of certain type, say IgG for example, the other antibody types like IgM and IgA are often decreased. It is just part of the disease process to see a paradoxical lower of other antibody types that are not involved in smoldering myeloma. ...Read more