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Doctor insights on: Causes Of Mixed Connective Tissue Disease

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I am taking sulfasalizine for mixed connective tissue disease. I have developed thrush. Would this med. Be the cause?

I am taking sulfasalizine for mixed connective tissue disease. I have developed thrush. Would this med. Be the cause?

Almost certainly: Your thrush is likely the tip of the iceberg-antibioitics like sulfsalizine kill our friendly flora but don't kill yeast, leading to overgrowth throughout the GI tract (known as intestinal candidiasis). This is treated with a low starch diet, probiotics & antifungal drugs or herbs. See http://www.Huffingtonpost.Com/dr-mark-hyman/yeast-infection-symptoms_b_657354.Html & http://bit.Ly/1aeoabl. ...Read more

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Tissue (Definition)

The body is composed of tissue that are classically described as beiing derived from three basic embyonic layers known as the endoderm, mesoderm and ectoderm that then differentiate into the structures that compose the body such as skin, soft tissues, bone, muscle, organs, etc. Stem cells are not differentiated and have the potential to ...Read more


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Is there a connective tissue disease that can cause widespread OA? I feel like something is being missed. I'm only 36. Is it just out of my control?

Is there a connective tissue disease that can cause widespread OA? I feel like something is being missed. I'm only 36. Is it just out of my control?

No: OA is by definition osteoarthritis, otherwise known as degenerative arthritis and is not "caused" by a connective tissue disorder. This is not to say that you have OA, but rather the search for other causes of arthritis is usually to investigate inflammatory causes such as, for example, RA, lupus, etc; which usually involves a thorough rheumatology evaluation. ...Read more

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Can the systemic inflammation from undifferentiated connective tissue disease cause intermittent dizziness ?

Can the systemic inflammation from undifferentiated connective tissue disease cause intermittent dizziness  ?

Inflammatory disease: Sounds like you have been given the dx of fibromyalgia. Otherwise, you have a very vague problem which is questionable in its diagnosis. You are much more likely experiencing vertigo due to the serious medications you are on versus systemic inflammation. Both Plaquentil and Cymbalta (duloxetine) are well known for causing vertigo. I would suggest talking with your rheumatologist about alternate drug treatment. ...Read more

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Could undifferentiated connective tissue disease (poss sjogrens +\or lupus) cause increased feeling of being winded when it is humid outside?

Could undifferentiated connective tissue disease (poss sjogrens +\or lupus) cause increased feeling of being winded when it is humid outside?

Difficult question: And one that probably can not be answered on this sit specific to you. Some kinds of connective tissue diseases can cause constriction and make you feel short of breath, others not. It is vert variable. The ones you mentioned probably not ...Read more

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I have connective tissue disease. What kind of viral illness would cause this--have low white count and sometimes not enough neutrophils.

I have connective tissue disease.  What kind of viral illness would cause this--have low white count and sometimes not enough neutrophils.

See below: Some viruses ranging such as the common cold have implicated in triggering autoimmune connective tissue diseases but you have to have a genetic prediposition for autoimmune disease for this to even occur. However; the autoimmune disease can itself can cause low white blood cell counts and neutrophils. ...Read more

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Skin biopsy shows early connective tissue disease. What is connective tissue disease? Why would it cause a chest rash? Or flushing w/ stress, emotion?

Skin biopsy shows early connective tissue disease. What is connective tissue disease? Why would it cause a chest rash? Or flushing w/ stress, emotion?

Get 2nd pathologist: "Connective tissue disease" was an obsolete word for the lupus / scleroderma / dermatomyositis family decades ago. Unless this is a second-hand report of a biopsy that showed nonspecific inflammatory changes that anybody can have, I would ask that the case be reviewed by another pathologist if the rash might be a real problem. Lots of folks flush with stress ("stress urticaria"); it's normal. ...Read more

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If autonomic dysfunction caused by connective tissue disease.Would treating connective tissue disease control the autonomic disease sx? Ie prednisone?

If autonomic dysfunction caused by connective tissue disease.Would treating connective tissue disease control the autonomic disease sx? Ie prednisone?

Very possible: Autonomic dysfunction is a frustrating condition. If you did every measure that your doc suggested but to no avail, treating connective tissue disease with steroid may possibly help. ...Read more

Connective Tissue (Definition)

There are many types of connective tissue, but in general it is a mass of fibers and thick "goopy" fluids secreted by specialized cells. The body often uses connective tissue to help ...Read more