Doctor insights on:
Causes Of Metastatic Adenocarcinoma
Metastatic tumor: The treatment of metastatic adenocarcinoma depends on the nature of the primary, the site of metastasis and the degree of metastatic tumor. Pancreatic Ca with one lesion in the liver is unresectable and treated by chemo such as Gemzar (gemcitabine) Abraxane. Colon Ca with one lesion to liver is resected. When any met is unresectable chemo is always used alone or in combination with RT. ...Read more
Regional spread: Many tumors, as they evolve, develop the potential to spread. The lesions develop matrix metalloproteinase which forms small e-cadherin from the cell cement and allows for spread. Regional nodes are a common site and for lesions on the arm and chest, spread is to the axilla. Lt. breast carcinomas as they grow and spread frequently are noted in the left axillary lymph nodes as metastatic adenoca ...Read more
My mother has been diagnosed with metastatic adenocarcinoma with mucinous features. Can you explain what this means?
Glandular activity: Primary tumors with mucinous features are those that are derived from organs producing mucin to allow the organ to function. The most common organ whose tumor, an adenocarcinoma, has mucinous features is that from colon. As such the metastatic tumors would have segmental areas within the spreading lesion that demonstrates the presence of fields of mucin on histologic exam. ...Read more
What do you suggest if my mother has been diagnosed with metastatic adenocarcinoma with mucinous features. What does this mean?
Many things: Adenocarcinoma means a cancer derived of epithelial cells of glandular origin (not from a gland necessarily). Metastatic means that it has spread. Mucinous features means that the pathologist saw areas of mucin outside the cells, the significance of this depends on how much and where. It being metastatic is probably the most important thing prognostically, but please discuss with oncologist. ...Read more
Several things.: In this sentence metastatic most likely means the disease has spread to other organs such as liver, lung, etc. And would be considered stage 4; alternatively it could mean spread to lymph nodes only and would represent stage 3 disease. Signet ring is a description of what the cell looks like. Adenocarcinoma is the type of tumor and can arise from the GI tract, prostate, lung, breast or stomach. ...Read more
Subtype of colon Ca: Mucin producing metastatic adenoca of the colon is derived from a primary adenoCa of colon producing large amounts of extracelluar mucin with greater than a 50% mucinous component. The proximal colon and appendix represents 10-20% of these colorectal neoplasms. The rt. Colon is the usual source for most of these lesions presenting with more advanced forms of disease than other colonic sites. ...Read more
My mum 67 was diagnosed with metastatic caecal adenocarcinoma, aggressive, stage 4. She started folfox. Can it be cured? Life expectancy?
Serious diagnosis: Stage 4 colon cancer has a very poor prognosis. No one can give you a life expectancy that is exact. It depends upon her response to the treatment. Some people respond very well. Of all people that have this diagnosis only about 8% of them are still alive at 5 years. But still she could be one of that 8%. I hope she responds well to the treatments. ...Read more
My mum 67 was diagnosed with metastatic caecal adenocarcinoma, aggressive stage 4 cancer. She's on folfox. Life expectancy??
Varies from months/y: The overall survival of stage 4 colon cancer varies from 1 to 3 years. Most patients have at least 2 years if their tumor responds to chemo. If you tumors regresses after chemo, it may even be surgically removable in which case long term survival (even a cure) can be possible. Ask more questions to your treating oncologist. ...Read more
Hello, Please let me know what is the reason for occur metastatic lymph node cancer??? 2nd Question : Is Adenocarcinoma is called tumor??? What happen
Yes it is a cancer: Adenocarcinoma is one type of common Cancer which can arise from any gland forming organ such as Breast, Colon and lung. If left untreated for a long time, cancer cells spread and can involve regional lymph nodes and later spread to the internal organs. I hope you are under the care of a cancer specialist (Oncologist) who can guide you further and offer the required treatments. ...Read more
Multiple causes: Adenocarcinoma is a cancer that arises from glandular elements in various organs. It is a general term for a number of cancers, including those arising from breast, lung, stomach, pancreas, and colon. These different diseases have different causes, and for many cases the cause is unknown. Your question did not give enough information to allow a more detailed response. ...Read more
I was wondering is a 5mm adenocarcinoma (pre-cancerous rectal polyp) cause for immediate concern?
Clarify: Adenocarcinoma is not precancerous, it is cancer. 5 mm is pretty small, which makes it sound like a polyp (not adenocarcinoma). If that was the case (maybe called a tubular adenoma?), there should be nothing to worry about. Adenocarcinoma in the colon/rectum implies invasion deeper into the colon. Please clarify the results of your biopsy with your doctor. ...Read more
What do you suggest if my grand father had adenocarcinoma and I want to know what causes it or what contributes to you getting it?
Depends: "Adenocarcinoma" is a general term for a cancer that begins in the glandular elements of an organ. Thus, adenocarcinoma can refer to cancer of breast, lung, pancreas, stomach, bowel, etc. Your risk would depend on where that cancer was, what age it occurred, and who else in family had cancer. If grandfather was only cancer case, and if it was at an advanced age (over 50), hereditary not likely. ...Read more
No: Asbestos has heen associated with the development of pleural mesothelioma. That appears to be its only associated malignant disorder. Considering that over a hundred thousand patients develop colon cancer yearly in the US, non have any history of such exposure. Rather it is believed that polyoma virus has an association with colonic neoplasms where tumor began as a GI inflammatory process. ...Read more
It varies: It depends on their organ of origin. Adenocarcinoma of breast is much different than one arising in the colon or in the lung. Sometimes we can not find their primary origin...So called adenocarcinoma of unknown primary (acup) which has once of the worst outcomes and it causes serious trouble in 4-6 months. If you can tell us your complete history, I can be more exact in my response. ...Read more
Potentially serious: Signet ring adenocarcinoma can occur in the stomach, intestine, or in other organs. The stage of cancer is most important in terms of prognosis, and how serious a cancer is. However, signet ring carcinomas are generally more aggressive than non-signet ring adenocarcinomas. ...Read more
Almost all of them: From top to bottom, here is a sample: salivary glands, thyroid, lungs, esophagus, stomach, breast (s), pancreas, intestines, biliary system, ovaries and peritoneum, prostate, uterus, adrenal glands, other glands, skin glands. Secondarily advanced adenocarcinoma from any origin may spread to other locations too: brain, liver, lungs, bone, skin, lymph nodes. ...Read more
It is cancer: Adenocarcinoma is a cancer that originates from glandular epithelial cells. This is usually classified as poorly, moderately or well differentiated based on the resemblance of these cells to normal epithelium with the well-differentiated cells being most similar in appearance to the normal cells. The poorer the differentiation, the more aggressive and poorer prognosis. ...Read more
Us government maintains some good health info at cancer. Gov. Here's the link to the pdq on esophageal cancer:
http://www. Cancer. Gov/cancertopics/pdq/treatment/esophageal/patient/page1
there are a lot of websites out there that have a lot of questionable information--sometimes it's hard to know where to go to get good information.
Good luck, and be sure to return to health tap for any questions! ...Read more
Poor: Rare cases of early pancreatic cancer can have long term survival- mostly the average survival is 20 months. For advanced cases the average survival ranges from 6-10 months. ...Read more