Doctor insights on:
Causes Of Lymphocytosis
What can cause mild lymphocytosis with slightly elevated T and B cells, as well as mild reticulin fibrosis?
Context: Any lab test result needs be interpreted along with your symptoms and findings. The above per se means little although it may suggest the presence of a viral infection. ...Read more
Multiple causes: You have a low level of one kind of white blood cell, the neutrophil. Most common cause is viral infection, esp. If transient. Many different medication can do this as a side effect, including non-prescription meds. Rarely, nutritional deficiencies (iron, B12 or folic acid). It can be part of autoimmune disease, it can be congenital, be due to serious blood diseases, or be benign. ...Read more
Hypostatic pneumonia: Hypostatic pneumonia is a term used to describe fluid accummulation in the lower portions of lungs in bed-ridden individuals (typically elderly). One thing you can do to reduce a pneumonia risk is to have your physician provide you with an early pneumonia shot (pneumovax /ppsv-23) before age 65. ...Read more
Is idiopathic lymphocytosis a thing? I have had lymphocytosis for >1.5yr, (prev doc never said anything) but no determinable cause. Also have anemia
Ideopathic=Basis not: Understood. Lymphocytosis: vague term for ↑ed concentration of lymphocytes (5 major types) in peripheral blood count than considered usual (Many Docs don't mention what they don't understand.). If a colony of lymphocytes in bone marrow are reproducing fast & crowding out RBC reproduction, this could be one basis for the anemia. If severe enough this is called leukemia; many different seventies. ...Read more
Possible causes of long-term (1O+ mo) lymphocytosis in 25yo female with iron-deficient anemia, but otherwise healthy?
I understand that monoclonal B cell lymphocytosis can cause an elevated WBC. Could it cause a high or very high CRP as well?
No: As a lab specialist I do not recommend even ordering a CRP except as part of a focused rheumatology workup. If you feel well, usually you never find the cause of the elevation anyway. Some people just run it high. If you have horrible ulcerative atherosclerosis, which is one cause, your doctor would know already. Otherwise, it really doesn't give useful information if you feel well. ...Read more
Generally speaking (& this can only be a general question because of the lack of additional Information), would it be unusual (even if it is possible) for monoclonal B cell lymphocytosis, by itself, to cause a very high CRP going up to 148.5 mg/L?
Unusual: It would be unusual for monoclonal B cell lymphocytosis to cause this high CRP. ...Read more
See a hematologist: See a hematologist asap. Don't delay...Get a more detailed answer ›
What to do if I have been diagnosed with mild peripheral leukopenia and neutropenia with associated relative lymphocytosis,?
Depends.: Leukopenia means low total white blood count. Neutropenia means a specific kind of WBC, neutrophil, is low. Relative lymphocytosis means the lymphocytes in the blood are not low. There are many causes of neutropenia: drugs, infections, autoimmune diseases, bone marrow diseases, congenital, nutritional deficiency, etc. Only if neutrophils are ...Read more
Husband had a splenectomy of an over 10 lb spleen and was diagnosed with persistent polyclonal b cell lymphocytosis what exactly is this condition?
Good question: Polyclonal refers to a generalized increase in lymph cells, as opposed to a single clone of cells which is what cancer (lymphoma) is. This diagnosis is rare, usually is seen in women, often smokers, and may be associated with exposure to epstein barr virus. The long term risks of the disorder are unknown. The is rare enough that I would have the pathology reviewed at a university hospital. ...Read more
I've had relative lymphocytosis on every blood test for a year now + now the absolute count is a little high too. Is this at all concerning?
Hi, I'm wondering if anyone has done any peripheral smear? Any infectious or connective tissue work up? Although lymphocytosis is not a common side effect for Abilify (aripiprazole) but there has been some report,
Your doctor could order a Flow Cytometry to make sure no blood malignancy existed although I highly doubt that. ...Read more
What does it mean if flow cytometry results show: "Relative T-cell predominant lymphocytosis with no other diagnostic abnormalities detected."?
Non diagnostic: For clonal proliferation, non-specific changes. Talk to your ordering physician about the plan of care. ...Read more
My flow showed relative T-cell predominant lymphocytosis. MD says do not have T-cell leukemia but keep testing every 6mo. Do I have smoldering TLL?
T lymphocytosis: Reading Blood 84: 2721-2725, 1994, Brit J Haematol 58: 433–446, 1984, N Engl J Med 359:575-583, 2008 and other articles may give you some perspective. The estimate is that TLL may appear in 1-2% each year. Nobody can predict as yet which patients will have further problems, therefore your doctors desire for follow-up, Prudent care and good medicine. Good luck. ...Read more
Generally speaking, if monoclonal B cell lymphocytosis deteriorated or transformed into something worse, what sort of pathological or other medical information would warrant taking a biopsy?
Lymph nodes: If you develop enlargement of lymph nodes, spleen or liver, a biopsy would be warranted. ...Read more
Viral infection: A high white blood cell count is leukocytosis (generic), and out of the PMNs, Lymphocytes, Monocytes, Eosinophils and Basophils, your test showed an increase in the # / % of Lymphocytes (specific). They usually are elevated when your body is fighting off a virus (like the common cold). ...Read more
Ask what it means: A few extra lymphocytes in your blood may be chasing off a virus that will never become symptomatic, or may indicate a viral illness (how do you FEEL?), whooping cough, a tumor of lymphoid marrow cells, or just being a bit stressed. As with all lab tests, the clinical picture makes all the difference. If there's abnormal cells, it's more worrisome. ...Read more
I've made blood sample analysis ANA found that I've relative monocytosis and relative lymphocytosis should I worry about it?
Why sampling: The biggest question is - why was the sample drawn and ordered? I would recommend discussing this with your primary doctor or the provider who ordered this. If this was a science experiment I would recommend repeating this by a real laboratory before drawing conclusions. ...Read more
My test came with mild microcytosis & mild neutropenia with relative lymphocytosis. The doctor didn't bother to bring it up, should I be worried?
Need the numbers: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, it would have been helpful to have the actual numbers. However, your doctor is in a better position to judge your health status and it is reasonable to trust her/his judgment. ...Read more
Should I worry about persistent *relative* lymphocytosis? 3 CBCs in 2 yrs show ~60% lymphs, ~40% neuts (both within absolute ranges, total WBC ~5.5K)
Numbers are just...: Numbers are just numbers. Without the whole picture, such as why was labwork done, numbers usually cannot tell much. The result values in this question, in a healthy person, are generally considered normal. One should ask his ordering doctor if the result is ok in the setting of his whole picture. ...Read more