Doctor insights on:
Causes Of Lupus Pernio
Skin sarcoidosis!: Lupus perneo is a manifestation of sarcoidosis, usually seen in chronic disease. Intra-lesional steroid injections can help, as can systemic therapy. Sarcoidosis is an autoimmune disease that can affect many organs, but more common and serious, the lungs. This disease needs rheumatologic management. The new tnf-alpha inhibotrs seem to work quite well, although this is off-label use! ...Read more
Genes, environment: This answer will change as we know more about lupus. We believe that for a person to get lupus, from the limited genetic information we have now, about 10% is from known genetic causes and remaining 90% unknown genetic causes and environmental causes. Environmental causes are largely undefined but important. Think about this: only 30% of identical twins develop lupus together. ...Read moreSee 1 more doctor answer
SLE diagnosis: Systemic lupus erythematosus is best diagnosed by an experienced rheumatologist. It is an autoimmune disease. A high-titer ANA, >1:320 is both sensitive and specific for lupus. Other auto-antibodies can help to confirm the lupus diagnosis. Anti-Smith is highly specific for lupus but not very sensitive. Anti-dsDNA is also highly specific and tends to be seen in lupus with kidney involvement. ...Read more
Absolutely. As an: auto(self)immune(complex internal system which best protects from cancer, viruses, fungi & bacteria), any portion of the body can be targeted resulting in what ever consequences. Commonly, the arterial/capillary system is involved in the self-attacks. Since all the cells of our bodies are dependant on blood supply, they can all be damaged/die even if not attacked as a direct target of the disease. ...Read more
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