Doctor insights on:
Causes Of Low Globulin
What can cause low serum globulin, 1.5 (reference cutoff 1.6)? Can slightly low globulin have an affect on the accuracy of other labs?
May not be anything.: It's not clear if such a small reduction means anything. Globulin on a chemistry panel measures a group of blood proteins that include antibodies. A low globulin can mean lowered immunity, but not always. Additional testing (quantitative immunoglobulins) should be done to verify normal immune function. ...Read more
Tested for autoimmune and reoccurring chest/sinus/flu illness cause. Low gamma globulin and IgG but normal subclasses, is this significant to symptoms?
See allergist/immuno: Thought I have answered a very similar question. You need to get tested on how your body responds to vaccination (usually pneumococcal and tetanus toxoid) since it is not just the quantity but the function of your IgG which matters the most. A B/C allergist should be able to handle this for you ...Read more
Liver blood tests: The liver is an amazing organ- it does many things including making proteins your body needs. Albumin is a major protein product of the liver. Chronic illness can cause that to decline- esp. If you're not eating. Globulins are other proteins usually made to fight diseases like infections- perhaps you've been fighting an illness for a few weeks/months that explain this pattern. ...Read more
Depends on profile: Serum protein levels are made up of a variety of proteins, albumin, as well as alpha, beta and gamma globulins. If you get a serum protein electrophoresis, the relative quantities of these proteins can be assessed. Most commonly, the Albumin level can go up or down depending on fasting levels. The other levels can go up or down depending on disease conditions or medications. See your internist. ...Read more
On low carb diet last few bloodwork globulin normal but each time lower 3.0 2.8 now 2.5 what would cause this?
Not significant: The globulin is something we usually don't have to pay any attention to. It's blood proteins other than albumin, which is the primary blood protein. They do include the gamma globulins that are important to fight infection and can be deficient in very rare diseases. But you are describing a small change that doesn't look important. ...Read more
Globulin nml but is decreasing urinalysis nml and grf remains between 80-97 depending on my diet for 10 years. Could low carb diet cause this or what
What is the problem?: Glomerular filtration rate estimated from a spot serum creatinine means very little; bodybuilders are all in early kidney failure. If your globulin is reasonably close to the normal range, and your Albumin is as well, I would not be concerned especially if your physician is not. ...Read more
What could be the cause of a low calcium level of 8.2? Albumin 4.6, Globulin 1.8, BUN 16, Vit D 38. Sodium slightly elevated but all else in range
Does low serum globulin affect blood tests that assess immunoglobulin levels? For example if an illness caused proteinuria, could a disease actually cause the test for it to be falsely negative?
Depends: If your immunoglobulin (s) is low especially when it involves igg, your immune system is likely impaired. It is not a "false-postive" result although the cause for the deficiency may vary and treated accordingly. ...Read more
I had blood work done & my a/g ratio & my sgot were low but my globulin count was high. I also have enlarged spleen & liver. What could cause this?
Very complicated: Too many illnesses to discuss in this forum. If you have hepatosplenomegaly you need to be seen by a pcp and perhaps referred to someone with expertise in this area. Obviously you must be seeing somebody now and being evaluated. Ask them... ...Read more
What can cause elevated alkaline phosphatase, beta globulin, TIBC, Compliment 3 +4, C-react. Protein and low ferritin, MCV, MCG and iron saturation?
Low iron: Elevated alk phos is seen with liver and bone disorder. Iron deficiency is suspected, but chronic inflammation may cause most of the lab abnormalities. A hematologist could shed some light on these varied lab abnormalities. Collaboration with a rheumatologist would also be helpful to identify a chronic inflammatory process. ...Read more
Increased aldolase, complement c3/c4 serum, sed rate, c-react. Protein, beta globulin, monocytes, bun/creatin low mcv-mch, vit d-possible causes?
Complicated: When I was doing clinical medicine, these were collectively sort of the flags for sarcoid disease but I am not saying that's the case here. This is because sarcoid is a diagnosis of exclusion so the advice is to rule out other diseases with additional diagnostic tests which can be done by a primary care physician or rheumatologist. ...Read more
Daughter diagnosed with Celiac Disease 8 weeks ago. Now has severe itching on lower legs only at night time. Low white blood count and high Globulin Serum levels. Severe weight loss, and bruising What could cause this? Itching Issues
There is a very: Characteristic skin rash that accompanies celiac disease: dermatitis herpetiformis. Typically this is a skin manifestation of non-celiac wheat sensitivity. Extremely itchy bumps or blisters appear, especially on the forearms. The lab abnormalities you describe are not typical for celiac; in fact serum globulins may be low. I suspect more than one diagnosis; continue working closely with her Doctor ...Read more
Blood proteins: It's all of the blood proteins except albumin. Levels may be up in a host of illnesses too numerous to name, or you may simply be a bit high because you're one of the several percent of people who fall outside a range that is set so that several percent of healthy folks fall outside. You list yourself as having "colitis" and ulcerative colitis, crohn's and antibiotic colitis can raise it. ...Read more
Be more specific: There are lots of globulins & to answer your question we need to know the type and reason the test was done. People have a range of antibody levels, globulins in certain classes, IgA, IgG, Ig E, or specific globulins to a prior illnesses or vaccinations. Without knowing specifics we cannot provide a specific answer. You are welcome to start over. Posts are not linked so each must have all info. ...Read more
I'm a quadriplegic. I had my hfp done and my globulin is 3.8. My a/g ratio is 0.9. Everything else looks good. Cause for concern?
Lab data: These values are fine and have no meaning unless used in the context of some underlying clinical issue. Would not worry about this value or the ratio. You should be fine. ...Read more
Does any one know what a huge drop in globulin means and what could cause ankylosing sponditilits?
In my case I have low globulin 1.8 and high a/g ratio. I definately fasted prior. I'm a 31 year old female. Healthy. I do try to eat a lot of protein?
Insufficient info: Globulins consist of a number of different proteins, and you need a serum protein electrophoresis, as a start, for a detailed examination of the different proteins. Please consult the doctor who ordered the test. ...Read more
See below: There is not enough room here to list all the causes of these values to be evaluated. What we need to know in order to best answer this question is what symptoms were you having for your doctor to order this blood work. ...Read more
Need more info: Lab test results need to be interpreted in the clinical context and is best done by the doctor who ordered the test as s/he likely knows your health history. A doctor needs to know the actual values of the results and more clinical information. ...Read more
IgA Deficiency: Sounds like selective IgA deficiency, if these are the results. Selective IgA deficiency is the most common immunodeficiency in the world and is usually benign but needs to be followed. IgA def in women is more significant since it can convert to common variable immune deficiency and there is HUGE risk of lymphoma development in the 50's-60's. See an immunologist ...Read more
Hello. My blood work shows slightly Low Globulin and High Alanine 2.1 low and 49 high What could this mean?
All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, the information your provided does not add up. It would be prudent to discuss it with the doctor who ordered the tests.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex.
Get HPV vaccine. ...Read more
What does it mean to have low alk phos levels and ALT levels globulin low and could there be something underlying?
No: Vulval dermatitis is a local issue and usually has no systemic manifestations including changes in the level of globulin. I wonder if you do have changes in the globulin level and vulval lesions, the latter being a manifestation of another systemic disease and not vulval dermatitis per se. ...Read more
Can a simple infection cause gamma globulin levels to decrease below normal range? (0.37 when normal is 0.7-1.6)?
No: Very unlikely, unless the patient is already immune compromised, main causes for this low level would be diseases/disorders leading to loss of protein from gut/kidneys or malnutrition. Low level of immunoglobulins has other causes though, lymphocytes problems, either T cells or B lymphocytes, that lead to immunodeficiency states, wish you wellness ...Read more
Can fasting cause an elevated (4.2) globulin level? What about fasting followed by a high protein meal before the test?
My bun/creat, (21), total protein (8.3), globulin (4.4) levels were high and alb/glob (0.9) ratio. Low how can these affect me?
It's possible: Sex-steroid binding globulins affect the levels of hormones (both male and female hormones). Some hormone deficiencies can cause fertility problems, but they certainly are not specifically effective in preventing pregnancy. If you are trying to conceive, see a doctor. If you are trying not to conceive, see a doctor! ...Read more