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Doctor insights on: Causes Of Increased Total Bilirubin

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What can be the cause of an elevated conjugated bilirubin with normal total bilirubin?

What can be the cause of an elevated conjugated bilirubin with normal total bilirubin?

Not concerning: As long as your total bilirubin is normal, the proportion of direct to indirect or conjugated to unconjugated bilirubin, is of little significance. It is really only of concern, if the total bilirubin is elevated. ...Read more

Dr. Gary Sandler
106 Doctors shared insights

Total Bilirubin (Definition)

Bilirubin, a product of hemoglobin breakdown, is present in two forms in the human body: unconjugated (indirect bilirubin, insoluble) and conjugated (direct bilirubin, soluble). Unconjugated bilirubin is conjugated in the liver and released into the small intestine in bile, the fluid in the gallbladder. Total bilirubin measures indirect bilirubin plus direct bilirubin; part of ...Read more


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Over 6 weeks total bilirubin has been 2.4, 1.8, 1.9, 2.2. Direct 0.2, 0.6, 0.7, 0.7. other LFT normal. Can gilbert cause mild mixed hyperbilirubinemia?

Concerning: I would look for another cause, perhaps Dubin-Johnson or medications. Are you taking some unregulated "holistic" medicine? They are often not what they are supposed to be, and some are liver poisons. ...Read more

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Total bilirubin is 1.78 I have taken test twice in gap of a week Direct has increased While indirect has decreased Sgpt was normal What is the prblm?

Total bilirubin is 1.78 I have taken test twice in gap of a week Direct has increased While indirect has decreased Sgpt was normal What is the prblm?

Possible Gilbert's: Gilbert’s syndrome is due to deficiency of an enzyme that helps to excrete bilirubin. It is usually diagnosed between the ages of 15 and 30 years. Patients with Gilbert’s syndrome are prone to develop jaundice from time to time. The risk increases with fasting, dehydration, repeated and profuse vomiting, infections, exertion and stress and after a surgery. If uncertain, specific tests can be done ...Read more

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Can hyperbilirubininemia (total bilirubin 76 umol/L) be treated if (1) the cause is unknown and (2) if the cause is known. If there is any treatment then what is it?

Depends: If your hyperbilirubinemia is due to an underlying problem such as cholestasis or liver disease (what are other liver values?), then those should be addressed. Some people have Gilberts which causes elevated bilirubin occasionally with no sequelae. ...Read more

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Will glucose of 118 and hgb A1c of 5.7 cause a high total bilirubin number?

Will glucose of 118 and hgb A1c of 5.7 cause a high total bilirubin number?

No: This is excellent diabetes control (if diabetic), borderline sugar if not diabetic. Elevated bilirubin, your doctor needs to find the cause. Gilbert syndrome may have slight high bilirubin (normal variant usually <3). Liver disease, gallstone obstruction : needs attention talk to your doctor. ...Read more

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What would cause my sgpt and sgot numbers to go back to normal but my total bilirubin to go up? (1.8) normal less than 1.4.

Bilirubin: The most common cause of a mildly elevated bilirubin is gilbert's syndrome -- this is a benign process that requires no additional workup. ...Read more

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LFT blood test shows an increase in Total Bilirubin from 10umol/L to 18umol/L in a 3month period. Should this be any cause for concern? Thoughts?

Relax: Please forgive my frankness -- the reference range for total bilirubin is usually around 3-25, and you need to stop paying so much attention to your labs. Bilirubin, and many of the others, fluctuate wildly from day to day. Your bilirubin may climb if you skip a meal, go for a run, take a medication that just happens to do this to you. ...Read more

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Hida scan showed my gallbladder is only functioning 15%! is that why my total bilirubin was always high & I have severe acid reflux? What else could it cause?

Hida scan showed my gallbladder is only functioning 15%! is that why my total bilirubin was always high & I have severe acid reflux? What else could it cause?

Have you had US?: Ultrasound of the upper abdomen can show presence of sludge or gall stones, a dilated bowel duct, pancreatitis, and architecture of liver. Any of these findings could contribute to symptoms. 15% gb ejection fraction is also caused by gall bladder dyskinesia without stones or sludge. Your doctor may also want to do endoscopy. Many things contibute to symptoms in the gastrointestinal tract. ...Read more

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Total bilirubin: 45 umol (HIGH) Direct bilirubin: 15 umol (HIGH) Liver biopsy was normal. What could have caused it?

? Gilbert syndrome: If you have no symptoms, it would be prudent to repeat the test in a few months. It is likely that you have Gilbert syndrome, a benign condition, with mildly elevated bilirubin. See this site for more info.

http://www. Mayoclinic. Org/diseases-conditions/gilberts-syndrome/basics/definition/CON-20024904 ...Read more

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Received test result of high total bilirubin at 1.9ml. Is this cause for concern? Doctor did not address it and called with normal results.

High end of normal: 1.9mg/dL is on the higher end of normal for total bilirubin. It is not cause for concern be itself, but lab tests always need to be interpreted in the context of medical history, exam findings and symptoms. One should always feel comfortable asking a physician to interpret normal or abnormal lab results. ...Read more

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Chronic Elevated Total bilirubin (2.5) direct bilirubin (0.5) and indirect bilirubin (2.0). All other liver enzymes are normal. What causes this??

Sounds serious: Hello again Matt. If your direct bilirubin is actually 0.5 mg/dL now, then this is more than Gilbert's which I understand is diagnosed. If this is not a lab error, then I suspect you have cholestasis too for some reason and you deserve a workup by somebody who's good with liver disease. Actually, the alprazolam / Xanax you're taking occasionally causes this. You might start there. Best wishes. ...Read more

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Total bilirubin 2.5 (Elevated), Direct bilirubin 0.5 (Elevated), Indirect bilirubin 2.0 (Elevated) All other liver enzymes normal. What causes this?

Rerun test: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, you need to re do the tests in non-fasting state. With the exception of elevated direct bilirubin, the findings are consistent with Gilbert syndrome, which is not a disease. See this site for more info:
http://www. Mayoclinic. Org/diseases-conditions/gilberts-syndrome/basics/definition/con-20024904 ...Read more

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What would would cause these results? High total bilirubin 1.2, low alkaline phosphates 38, low RBC 3.99, high neutrophils% 81.5, low monocytes% 3.2

Not enough info.: It's impossible to analyze isolated lab tests without having the results of all of the tests and an understanding of the patient's medical history, current symptoms, and physical exam results. Although the results don't seem alarming to me, you should discuss them with your doctor. As an alternative, you could upload them to HealthTap Prime and discuss the results with a doctor here. Good luck. ...Read more

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Could Adderall (dextroamphetamine and racemic amphetamine) cause an elevated total bilirubin?

Adderall (dextroamphetamine and racemic amphetamine): Elevated bilirubin is not listed as a side effect of adderall (dextroamphetamine and racemic amphetamine). Other medications such as Acetaminophen or Ibuprofen can elevate the bilirubin. A harmless entity called gilbert's can also cause an elevated bilirubin. See your doctor for elevation. ...Read more

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Causes? High total bilirubin 1.2, low alkaline phosphates 38, low RBC 3.99, high neutrophils% 81.5, low monocytes% 3.2. 25 girl otherwise healthy.

Not concerning: If all other labs are normal, including normal Hgb, normal WBC, normal liver function test, there is no concern for these mildly abnormal labs. You have to put together the whole picture so if you have no symptoms, I would not worry at all. ...Read more

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Sgpt 950 alkaline phosphatase 298 total bilirubin 5.5 direct bilirubin 4.4 kindly answer cause obstructive jaundice or hepatitis?

Liver functions: Both are possible. Need to also exclude alcohol abuse. If you do not drink excessive alcohol the check with your physician (for liver scan, CT etc.) ...Read more

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Gallstone, 31% EF, low total bilirubin, high anion gap, hx of elevated liver enzymes. Liver enzymes leveled out after taking hormones. Causes? Advice?

Gallstone, 31% EF, low total bilirubin, high anion gap, hx of elevated liver enzymes. Liver enzymes leveled out after taking hormones. Causes? Advice?

HF: You have complex issues. Why do you have HF and also the cause of liver disease? The AGMA is concerning and has to be worked up. Some of these conditions can be related. What hormones did you take? I have more questions than answers, more so because you have 2 organ dysfunction and a acid base disorder and they can be related. ...Read more

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Is total bilirubin 2.8 dangerous?

Can be: It is important to determine why the bilirubin is elevated. It may be a transient phenomenon due to a viral infection or the result of metastases to the liver and a whole lot of things in between. All lab results need to be interpreted in the clinical context and the doctor who ordered the test is usually in the best position to do that. ...Read more

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What does low total bilirubin mean?

What does low total bilirubin mean?

Low is OK: In general we all worry about elevated bilirubin. Low bilirubin does not suggest any particular illness, it can be cause by certain medications and vitamin c. ...Read more

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Is a total bilirubin level of 10 normal?

High: Normal values for labs are slightly different but usually normal total bilirubin levels are 0.5 to 2.0 mg/dl. Check the units of measure too. If your lab is using other than mg/dl then 10 may be normal. It is always best to check the normal values for the lab that has run your test. If you call them or your doctor's office they should be able to tell you definitively if your lab is abnormal. ...Read more

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My total bilirubin is 1.3, is this normal?

Yes: This is actually within the reference range for most labs, and these are set so that a fair number of healthy folks fall outside. ...Read more

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My total bilirubin is 13.7 is it alarming?

High Bilirubin: Level elevation, could come from Liver or Biliary tract. Consult your doctor for further evaluation. ...Read more

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Is a total bilirubin level of 21umol normal?

Maybe: Lab tests can be tricky! Is it 21μmol/l? Or maybe its 2.1? Or in mmol? (sometimes it can feel like high school physics again with all the unit conversions ;))

the bilirubin level might be elevated, especially if you have a reason (like a recent bruise, hepatitis, or gallstones). If you have concerns, talk to your doc! ...Read more

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What is the effect of high level of total bilirubin?

Brain damage in new: Born. High levels of bilirubin in newborns cause brain damage. In adults it is not the high bilirubin but the cause of bilirubin that is more important. ...Read more

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What could be wrong if my total bilirubin is 25.0 umol/l?

Liver: It has something to do with the liver. You need to be checked to see what kind of bilirubin it is to know where in the process there is a failure, but that level is significant. This can be caused by gallbladder issues, liver failure/issues, and blood breakdown. Get it checked out asap. ...Read more

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What is the definition or description of: total bilirubin?

See answer details.: Bilirubin, a product of hemoglobin breakdown, is present in two forms in the human body: unconjugated (indirect bilirubin, insoluble) and conjugated (direct bilirubin, soluble). Unconjugated bilirubin is conjugated in the liver and released into the small intestine in bile, the fluid in the gallbladder. Total bilirubin measures indirect bilirubin plus direct bilirubin; part of a liver test panel. ...Read more

Bilirubin (Definition)

Bilirubin is the potentially toxic product of heme metabolism. It is formed by breakdown of heme present in hemoglobin, myoglobin, cytochromes, catalase, peroxidase and tryptophan pyrrolase. Eighty percent of the daily bilirubin production comes from hemoglobin. It requires conversion to a water-soluble form before elimination from the body by ...Read more