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Causes Of High Direct Bilirubin
Bilirubin is the potentially toxic product of heme metabolism. It is formed by breakdown of heme present in hemoglobin, myoglobin, cytochromes, catalase, peroxidase and tryptophan pyrrolase. Eighty percent of the daily bilirubin production comes from hemoglobin. It requires conversion to a water-soluble form before elimination from the body by ...Read more
Chronic Elevated Total bilirubin (2.5) direct bilirubin (0.5) and indirect bilirubin (2.0). All other liver enzymes are normal. What causes this??
Sounds serious: Hello again Matt. If your direct bilirubin is actually 0.5 mg/dL now, then this is more than Gilbert's which I understand is diagnosed. If this is not a lab error, then I suspect you have cholestasis too for some reason and you deserve a workup by somebody who's good with liver disease. Actually, the alprazolam / Xanax you're taking occasionally causes this. You might start there. Best wishes. ...Read more
Can gilbert's also present with mildly elevated direct bilirubin (0.4-0.7)..with elevated total (1.4-2.2) Mostly indirect still some direct elevation?
Not from Gilbert's: Gilbert's syndrome causes a deficiency in the enzyme that converts indirect bilirubin to direct bilirubin. In other words, the only issue is that indirect bilirubin is converted to direct bilirubin more slowly. People with Gilbert's are not unhealthy from it and are not considered to have a "disease." If direct bilirubin is elevated, something else is going on. ...Read more
No: In general, smoking is not the cause of elevated liver enzymes. In your medical history I see you have a diagnosis of fatty liver. That is the likely cause of elevated liver enzymes. Other things to consider include infectious hepatitis, alcohol, toxins, tumors, and bile duct abnormalities. ...Read more
Hepatitis is suspect: Hepatitis b or c is an infectious and inflammatory disease that can cause protein in urine while causing elevated liver enzymes. Other conditions like lupus are to be considered. Also, 2 things could happen together like diabetes that causes protein in urine and obesity that causes liver enzyme increase. ...Read more
Direct billirubin of 0.49 , indirect level of 1.82. Normal CBC, other liver tests, and Ultrasound for liver. Is this indicative of gilberts syndrome?
Gilbert's disease: It is a familial (autosomal dominant), common (2-5% of people), unconjugated hyperbilirubinemia (blood bilirubin measures 1-5mg/dl), not due to breakdown of blood. It is associated with reduced enzyme levels of udp glycuronyl transferase, that results in jaundice when patients fast or suffer an infection. It does not shorten life or raise insurance rates, but may predispose to tylenol (acetaminophen) toxicity. ...Read more
Depends: This depends on the cause, level, & type of elevated bilirubin (conjugated vs unconjugated). There are many causes of high bilirubin levels, some of which are relatively benign, and some that may be serious. In some cases, high bilirubin may cause yellowing of the skin/eyes or increased risk for gallstones. In newborns, a significantly high bilirubin is dangerous due to the risk of brain damage. ...Read more
Total bilirubin 2.5 (Elevated), Direct bilirubin 0.5 (Elevated), Indirect bilirubin 2.0 (Elevated) All other liver enzymes normal. What causes this?
Rerun test: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, you need to re do the tests in non-fasting state. With the exception of elevated direct bilirubin, the findings are consistent with Gilbert syndrome, which is not a disease. See this site for more info: http://www.mayoclinic.org/diseases-conditions/gilberts-syndrome/basics/definition/con-20024904 ...Read more
High billirubin: Elevation of billirubin can be caused production. Accelerated breakdown of red blood cells. Liver disease one of many functions is to remove from blood stream. Blocked excretion billirubin should be deposited in gall bladder as bile salts any thing blocking exit can raise billirubin. I have simply covered about a couple hundred disease conditions. Need to consult your doctor. ...Read more
A 15 year old boy's total bilirubin is 0.8 and direct bilirubin 0.4. The total bilirubin is in range but direct bilirubin is slightly out of our lab range [0-0.3]. What might be the possible causes?
Meaningless: Difference. No clinical correlation.Get a more detailed answer ›
What are the possible causes when the total biliruben is elevated but the direct biliruben is normal?
Direct bilirubin: Measures conjugated bilirubin. The rest is indirect, or unconjugated, bilirubin. Causes of elevated indirect bilirubin is usually viral hepatitis. Other less common causes are hemolysis sickle cell anemia, liver toxins, and terminal liver failure. It means that liver cells are not working well. Time to see the doctor. ...Read more
Does Billirubin total of 3.2 and billirubin direct of 0.5 indicate a livr problem? if so what kind of disorder?
Probably Gilbert's: Gilbert’s syndrome is due to deficiency of an enzyme that helps to excrete bilirubin. It is usually diagnosed between the ages of 15 and 30 years. Patients with gilbert’s syndrome are prone to develop jaundice from time to time. The risk increases with fasting, dehydration, repeated and profuse vomiting, infections, exertion and stress and after a surgery. If uncertain, specific tests can be done. ...Read more
Bilirubin - direct, indirect, and total provide some clues to the underlying disease process. The direct bilirubin has to processed further by the liver for excretion out of the body. Therefore, the direct bilirubin level is generally used as an indicator for the function and ...Read more
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