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Doctor insights on: Causes Of High Ca 125

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Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Likely, no: CA 125 is not recommended as a screening tool for ovarian cancer when used in risk-based stratification. Meaning, assuming that your mom or sister didn't get diagnosed with ovarian cancer. Normal for women with endometriosis to have elevated CA-125. It sounds like your doctor has done Ultrasound to evaluate ovaries as well. Your MD knows your history and risk, likely this CA-125 level is normal ...Read more

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Dr. Suzanne Galli
125 doctors shared insights

Ca125 (Definition)

Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more


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Can Lyme disease cause an elevated CA125 reading?

Unknown: At this point in time there is a lot of discussion about this topic and many who feel there may be some association but there has been no known proof of an association of Lyme disease and an elevated CA 125. This is still being researched and nothing that can say a definite cause and affect. Hope this helps. ...Read more

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My ca 125 blood test result slightly elevated, with a different reading 3 times, what could cause this to happen?

My ca 125 blood test result slightly elevated, with a different reading 3 times, what could cause this to happen?

CA 125: A ca 125 is not a very accurate test. Anything that affects the lining of your abdomen (peritoneum), lung cavity (pleura), or sac around your heart (pericardium) can change the ca 125 level. This includes everything from a cold to kidney failure to cancer. ...Read more

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I'm concerned about high ca 125? What should I do?

Incomplete info: Why did you have the test done? All lab results need to be interpreted in the clinical context and the doctor who ordered the test is usually in the best position to do that. Ca 125 is not a good test to diagnose a primary illness. ...Read more

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Could you please tell me if a ca125 blood test is high do I need tahbso?

Could you please tell me if a ca125 blood test is high do I need tahbso?

Not always.: If this test is high, it could mean endometrial cancer, fallopian tube cancer, lung cancer, breast cancer and gastrointestinal cancer. This can also indicate benign conditions, like endometriosis, other ovary disorders, and pregnancy, as well as any inflammatory condition in the abdiminal area. This is a big reason why it is used with other tests in evaluation and to follow treatment response. ...Read more

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What causes my ca 125 to go up?

Many causes: It is commonly elevated in ovarian cancer. But it can go up from any reason which causes irritation of the peritoneal lining of your abdomen which includes some benign conditions too. It depends on the level and also if it is going up steadily or staying elevated but stable and not increasing. Your gynecologist can help you to sort it out. ...Read more

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Ca-125 was elevated at 40? Once told by gyno that I have precancerous cells. Should this combination worry me?

Yes!: Ca125 is a cancer marker. If elevated is something to worry , even though its not specific. If you were told to have a precancerous lesion , wherever it was, needs to be reevaluated. ...Read more

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Should I be concerned about elevated ca-125 of 132 if I have a history of benign cysts?

CA-125: This marker is quite non-specific for cancer, particularly in pre-menopausal women. Any things that irritate the lining of the abdomen (such as cysts, endometriosis, and non-ovarian things as well) can prompt elevations in the range you have noted. Other means of screening for cancer however are also imperfect. If you are at high risk, other follow-up may be needed. ...Read more