Doctor insights on:
Causes Of Biliary Cirrhosis
PBC Elevated LFT's: Primary biliary cirrhosis (pbc) itself is a terminal cirrhotic state of liver, requiring liver transplant. There is not much ast & alt enzymes left in liver to go up. Certain insults, can expedite liver damage, by elevated lft's: medicines metabolized by liver, alcohol, an obstruction in porta hepatis, ? Malignancy, need to be considered. ...Read more
Please tell me what can cause sudden elevation of liver levels in a primary biliary cirrhosis pt on meds?
Repeat and see GI: Primary biliary cirrhosis is an autoimmune disease of the liver that affect women more than men. Medications for treatment include ursodeoxycholic acid and steroids for acute flairs. Transient elevations may occur for a variety of reasons: 1) exacerbation of pbc; 2) injury to liver from another cause, e.g. Alcohol, tylenol; 3) viral infection, hepatitis or other virus. Repeat labs and see md. ...Read more
Liver problems: With primary biliary cirrhosis the small bile ducts in the liver are affected. As time goes on cirrhosis of the liver can result. This results in jaundice and itching. As cirrhosis worsens people have issues with enlarged veins around the esophagus, stomach and rectum. These can cause severe bleeding. Also complete liver failure can result. ...Read moreSee 1 more doctor answer
Autoantibody &Biopsy: In addition to abnormal blood tests due to malfunction of liver, patients with primary biliary cirrhosis have peculiar autoantibodies, anti-mitochondrial antibodies. Blood tests and imaging suggest cirrhosis, confirmation requires biopsy (usually needle biopsy) and examination of the tissue by a pathologist. ...Read more
Bad if untreated: An immuno-genetic disease, of which 90% are female, typically 40-60 years old. The disease affects asians, caucasians, jews, african. Family clustering is common. Early symptoms are fatigue, itching before jaundice, RUQ pain. Untreated pbc leads to progressive liver failure with its sequelae. Advanced age, liver/spleen enlargement, ascites, low albumin, fibrosis, cirrhosis predict worst prognosis. ...Read more
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