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Doctor insights on: Causes For Increase In Bun And Creatinine Levels

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I am 49 year old male in good general . A recent blood test showed bun level at 27 and creatinine level at 1.4. Should i be concerned? What are possible causes?

I am 49  year old male in good general .  A recent blood test showed bun level at 27 and creatinine level at 1.4. Should i be concerned? What are possible causes?

Dehydration?: Sounds like dehydration (if no kidney disease) as we grow younger, we cannot rely on our thirst, and have to drink by the clock... Our osmotic receptors get old before we do. ...Read more

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Dr. Madhu Kandarpa
2,203 doctors shared insights

Creatinine (Definition)

Creatinine is a byproduct of creatine phosphate, which is present in muscles. Creatinine levels increase if the ...Read more


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Would losing 12 pounds on an already petite woman and dramatically decreasing protein cause BUN creatinine level to drop from 15 to 6 in 3 months?

Would losing 12 pounds on an already petite woman and dramatically decreasing protein cause BUN creatinine level to drop from 15 to 6 in 3 months?

Loss of muscle mass: In addition to losing fat, you are losing muscle mass and that is reflected in the drop in creatinine. You may wish to increase your protein intake and exercise. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Drink enough water daily so that your urine is mostly colorless. Practice safe sex. ...Read more

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**BUN/creatinine level is 54.7**??? urea nitrogen is 29, creatinine is 0.53, eGFR is 128, potassium is 4.4. Cause for concern? I literally cannot find anything anywhere about a BUN/creatinine level that high.

**BUN/creatinine level is 54.7**???  urea nitrogen is 29, creatinine is 0.53, eGFR is 128, potassium is 4.4. Cause for concern? I literally cannot find anything anywhere about a BUN/creatinine level that high.

BUN/GFR 54.7: I would not worry. It is a ratio-calculated value . Your BUN is 29 ( normal < 20) but that could be due to either mild dehydration or high protein in body( unless you are actively bleeding) . Your creatinine is 0.53 which is great.The ratio is BUN/Cr 29/0.53 = 54.7 . Your GFR another number we look seriously at is 128 great, potassium is 4.4 normal . Do not worry it is an artifact of the math ...Read more

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Can weight gain from prednisone (20lbs) cause an increase in creatinine and bun? Have had increasing labs past 3 months. Been on pred 6mo. Almost off

Can weight gain from prednisone (20lbs) cause an increase in creatinine and bun?  Have had increasing labs past 3 months. Been on pred 6mo. Almost off

Unlikely: Prednisone may cause a negative nitrogen balance due to protein catabolism and, therefore, may cause a rise in bun. It may also cause sodium and fluid retention and potassium loss. However, I am unaware of any effects of corticosteroids on serum creatinine or glomerular filtration rate per se. If you do have sle, it is possible that you may have renal involvement. ...Read more

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Sle pt on cellcept (mycophenolate mofetil). If cellcept (mycophenolate mofetil) can cause increased bun why is it used for lupus nephritis? Also can it increase creatinine?

Sle pt on cellcept (mycophenolate mofetil).  If cellcept (mycophenolate mofetil) can cause increased bun why is it used for lupus nephritis? Also can it increase creatinine?

Because it works: Cellcept (mycophenolate mofetil) is the preferred drug for lupus nephritis because it is very effective and has much less risk than alternative meds. It does not cause significant elevations of BUN or creatinine. ...Read more

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Chf patient under 1L water intake a day, BUN level 63, creatinine 2.0 on lasix 40 mg maintenance dosage. Should water intake be increased a little so the kidneys don't conserve water? Asking because of decreased urination wirh stable GFR. Check Adh?

Chf patient under 1L water intake a day, BUN level 63, creatinine 2.0 on lasix 40 mg maintenance dosage. Should water intake be increased a little so the kidneys don't conserve water? Asking because of decreased urination wirh stable GFR. Check Adh?

CHF/ renal disease: This question is best asked to you cardiologist, as you have CHF and kidney damage so your fluid balance is very delicate. Drinking too much can put you back in CHF. Would recheck your creatinine and your creatinine clearence, EF on echocardiogram as it may have changed. Discuss this with your cardiologist ...Read more

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How can I lower my creatinine and bun levels?

Only if due to : Dehydration. If the elevation is due to dehydration you may lower it by drinking water. However, in almost all instances elevated BUN and especially creatinine. Warrant seeing your doctor asap. ...Read more

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I have a high bun/ creatinine level (28) and a low creatinine level (0.5) . Should I be concerned or do something?

BUN/Creat Ratio: I personally would not worry about it since the high ratio is due to a slightly elevated BUN. This might be due to a diet high in non-essential amino acids (nothing to truly be concerned about) or a mild lack of water intake. If you are still concerned, please see your primary doctor and go over all of that with her/him. ...Read more

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I have Creatinine level of 1.2, normal BUN, GFR of 56, I'm 31, prolacton level of 82. Any suggestions?

Um, those are: not necessarily abnormal. Prolactin has more significance if it is sky high (it isn't). The others at most would probalby indicate a bit of dehydration. ...Read more

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What is a bun/creatinine ratio? How is it calculated and if mine is 22 but my other levels are fine what should I do?

What are the actual: Numbers? BUN number divided by creatinine number. Normal range is 10-20. 22 may not be abnormal if individual levels of BUN and creatinine are normal. Discuss the numbers with your doctor at the next visit. ...Read more

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Healthy 35 yr old female w B/C ratio elevated at 23 with normal Bun and creatinine level of 16 (ref range 7-18) and 0.7. I did not drink much that day?

Healthy 35 yr old female w B/C ratio elevated at 23 with normal Bun and creatinine level of 16 (ref range 7-18) and 0.7. I did not drink much that day?

Tests, tests, tests: Tests results always have to be interpreted in a context. When they measure the temperature of the winner of the Boston Marathon 2 yrs ago it was over106 F. Was he very ill? NO! He had been using his bodies muscles at full output for over 2 hrs straight. The heat generated raised his body temp a lot and he soon cooled off. You hv to talk with yr doc or make a virtual consult. ...Read more

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Does pain medication cause hi creatinine and bun?

Does pain medication cause hi creatinine and bun?

Depends: Depends on what you are using or calling 'pain medication'. The non-steroidal anti-inflammatory agents (like ibuprofen, motrin, aleve, (naproxen) advil and certainly cause this. ...Read more

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What causes marked bun elevation with normal creatinine?

Co-tango usually: The BUN is usually 10 times the creatinine. When the creatinine goes up, the BUN goes up similarly to roughly keep this proportion, in most kidney disease states. The notable exception is when the creatinine goes up say by 20% to 1.2, but the BUN goes up *5 to 50. This strongly suggests a pre-renal state, commonly dehydration. Mild elevations of BUN with normal creatinines aren't of concern. ...Read more

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My creatinine is 1.53 and my bun is 13. Whatwould cause this.

Are you a big guy?: Creatinine increases with muscle mass; when I was lifting weights every day, mine ran 1.6-1.7. A few meds, notably cimetadine, raise the value. And you're getting a little bit older and kidneys may not be filtering quite so well. You'd do well to watch this over the coming years. ...Read more

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What does it mean if both bun & creatinine levels are good, but the ratio is high?

What does it mean if both bun & creatinine levels are good, but the ratio is high?

Actual values: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, if both creatinine and BUN are normal you do not need to worry about the ratio. ...Read more

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What does it mean if both bun & creatinine levels are good, but the ratio is high?

Need numbers: It would help to have the actual numbers. The doctor who ordered these tests would be in a better position to advise as s/he knows your health status. ...Read more

Dr. Ellen Bondar
256 doctors shared insights

Blood Urea Nitrogen (Definition)

It's level helps evaluate renal function elevation can mean poor renal ...Read more