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Doctor insights on: Cause Of Pyoderma Gangrenosum

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How common is sepsis with ecthyma gangrenosum?

How common is sepsis with ecthyma gangrenosum?

Very rare: I have never taken care of a patient with this despite working in an ICU for 7 years at a major referral center. There not even any case series published - just case reports, indicating that no one has been able to even accumulate enough cases at one institution to document more than a few. ...Read more

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Molecular mimicry is a possible cause of some forms of autoimmunity due to bacterial infection..Do fungal/viral infections ever cause autoimmunity?

Molecular mimicry is a possible cause of some forms of autoimmunity due to bacterial infection..Do fungal/viral infections ever cause autoimmunity?

Molecular mimicry: Why yes viral infections certainly do display molecular mimicry. Most commonly are the herpesvirus family (herpes simplex, varicella, cmv, ebv...16 in all). That is why these viruses remain latent within us and if the immune system is disrupted by acquired immunodeficiencies (age, chemotherapy, HIV or other viral infections) these viruses then reactivate. ...Read more

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What type of skin lesions commonly contribute to sepsis?

What type of skin lesions commonly contribute to sepsis?

Skin lesions sepsis: The larger the size of the wound, the more it is colonized with bacteria, the greater the entry of foreign matter (dirt, stool, foreign bodies), the longer that you have the wound -- are just some of the things that would lead more commonly to sepsis than not. ...Read more

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What is the cause of pemphigus vulgaris ?

What is the cause of  pemphigus vulgaris ?

Unknown: P.V. Is an autoimmune disease in which antibodies have been formed to proteins that bind skin cells together. As a result, bonds between cells are easily disrupted; a clinical finding referred to a nikolsky's sign in which skin blisters can be created by rubbing the skin. P.V. Typically causes skin and mucous membrane sores. Treatment typically begins with oral steroids and other immunosuppresants. ...Read more

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What are the symptoms of chronic granulomatous disease?

What are the symptoms of chronic granulomatous disease?

Chronic infections: Chronic granulomatous disease (cgd) is a genetic disorder in which immune system cells are unable to kill some types of bacteria and fungi. The disorder leads to long term (chronic) and repeated (recurrent) infections. The condition is often discovered in very early childhood. Milder forms may be diagnosed at a later age. Check this site. http://www.ncbi.nlm.nih.gov/pubmedhealth/pmh0002219/. ...Read more

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What diseases do non-pyogenic streptococci cause?

What diseases do non-pyogenic streptococci cause?

Usually no pathogeni: Non-pyogenic streptococci represent a diverse group of streptococci that are normal inhabitants of the mouth, throat and occasionally the gastrointestinal tract.  'silent bacteraemia' can occur especially in individuals with poor dental hygiene or gum disease. This can result in endocarditis amongst vulnerable individuals, especially those with underlying conditions such cancers, diabetes, heart ...Read more

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What are the causes of a autoimmune disease?

What are the causes of a autoimmune disease?

Genetics and enviro: It is a combination of genetics and the right enviromental triggers. We do not know all these triggers yet, but some people may the genes, but never have them turned on despite being exposed to a trigger. Hope that helps. ...Read more

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I suffer from granuloma annulare, erythema annulare centrifugum, erythema nodosum, and low IgM. Are these related or might they have a common cause?

I suffer from granuloma annulare, erythema annulare centrifugum, erythema nodosum, and low IgM. Are these related or might they have a common cause?

Unlikely: These 3 conditions have 3 different auto-sensitivity targets, in the skin. Biopsy appearance is different under the microscope, and treatments are different. The first 2 conditions usually respond poorly to any cream, but are not serious. E. Nodosum can be a sign of a more serious underlying disease, and stronger meds are needed. Please see a Dermatologist for treatment. ...Read more

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What is a serious disease of the lungs caused by the fungus histoplasma capsulatum?

What is a serious disease of the lungs caused by the fungus histoplasma capsulatum?

Histoplasmosis: Histoplasmosis is an initial infection of the lungs giving flu-like or cold-like symptoms...The fungus can sometimes infect the retina (the inside light sensitive lining of the eye). The infection can cause direct damage to the retina and if it affects the macula, central vision may be destroyed. Exposure to histoplasmosis correlates with chicken farming, the fungus lingers in the animal waste. ...Read more

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What is the cause of lupus erythematosus?

What is the cause of lupus erythematosus?

Autoimmune: Systemic lupus erythematosus is an auto immune illness. This means people have a immume response against themselves and their own tissues. The hallmark blood test is a positive anti-nuclear antibody or an ana. Depending on what tissue is involved results in the clinical symptoms such as rash, arthritis, kidney disease etc. The cause seems be a combination of genetic and environmental exposures. ...Read more

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Are septicemia and gangrene related?

Are septicemia and gangrene related?

They can be...: Septicemia refers to bacteria in the blood, usually in a very sick patient. Gangrene simply denotes dead tissue. If the dead tissue is infected and shedding bacteria into the blood, then they would be related. ...Read more

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What is the pathogenesis of villous atrophy induced by bacterial overgrowth ? How does it cause the atrophy? sprue-like enteropathy uknown aetiology

What is the pathogenesis of villous atrophy induced by bacterial overgrowth ? How does it cause the atrophy? sprue-like enteropathy uknown aetiology

I know: that you have been waiting for an answer and the problem is that there is none. You ask what the pathogensis of sprue like enteropathy of UNKNOWN etiology is.....the answer is its UNKNOWN...Bacterial overgrowth can be treated ..AND THAT'S WHAT IS IMPORTANT HERE!!!!! Your bowel symptoms helped with the use of certain ANTIBIOTICS! I hope this helps and that you have a healthier New Year! Dr Z ...Read more

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What kind of condition is cytomegalovirus (c.M.V.) infection?

What kind of condition is cytomegalovirus (c.M.V.) infection?

CMV: This is a virus with is very common and causes disease such as mononucleosus type diseases, serious lung or brain infections in some people who can't fight it because of suppressed immune systems. It is treatable with special antiviral antibiotics. ...Read more

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Are vascular conditions a common complication of inflammation?

Are vascular conditions a common complication of inflammation?

Yes: Almost all disease states have inflammation as a component. Now some micro-vascular autoimmune diseases are a direct result of an inflammatory process. I need more specifics of type of inflammation you are referring to. ...Read more

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What's the incidence (how widespread is the disease) of cryptosporidiosis?

What's the incidence (how widespread is the disease) of cryptosporidiosis?

See below: Cryptosporidium is found world wide except in antartica. Only 2426 to 3793 cases per year were reported in the usa from 1995-2002. The number of reported cases increased to 8000 per year from 2005-2007. Estimates suggest that more than 300, 000 persons in the usa are affected each year. The difference is caused by the underuse of diagnostic tests and underreporting. ...Read more

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What are the causes of acute tubular necrosis?

What are the causes of acute tubular necrosis?

Ischemia, drugs: Acute tubular necrosis (atn) can happen if the kidney has severely reduced blood supply (ischemia). This could be caused by hypotension (very low blood pressure), volume depletion (as a result of illness or trauma), problems with the blood vessels supplying the kidneys (renal artery blockage), and drugs that affect the flow of blood to the kidneys. Drugs and toxins can also directly cause atn. ...Read more

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What causes proteus mirabilis infection of the skin?

What causes proteus mirabilis infection of the skin?

Proteus mirabilis: This would be incredibly unusual and would seriously question the diagnosis. This organism is most commonly found in the GI tract and can cause uti. Often on the surface of the skin, but seldom if ever the cause of infection. See an infectious diseases expert and get examined. Good luck. ...Read more

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What type of cancer usually causes sepsis?

What type of cancer usually causes sepsis?

Not Cancer-Specific: Sepsis occurs when an infection enters the bloodstream, affecting many vital organs. The origin of the infection may be due to any number of different infections, ie pneumonia, utis, diverticulitis, etc. Cancer and its treatment may predispose people to develop these serious infections, but does not directly cause them. ...Read more

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