Doctor insights on:
Cause Of Itp
In the old days....: The "i" in itp stood for idiopathic, which means we didn't know what was causing the problem. We now know this to be an autoimmune process where antibodies recognize proteins on the surface of platelets and target them for destruction by the reticuloendothelial system. Most cases follow an infection (usually viral), but they can also be the presenting feature of autoimmune disorders or malignancy. ...Read more
Can chronic low & giant platelets (80-125) w/o a cause be ITP in adult w. Henoch Schonlein? In/out of HSP remission, Plts same, WBC/RBC vary low-norml
Hsp: Hsp doesn't cause any changes in platelet count. I am not sure what do you mean been in and out of remission. The chronic issues with hsp is the blood in the urine, butost of the time it is microscopic. Blood pressure need to be monitored. If you have other issues with platelet count, you probably need to see hematologist to help you sort it out ...Read more
What are the possible causes of both ITP & Bernard-Soulier Syndrome in a person? What effect, if any, do they have together? Thanks for your input.
Platelet troubles: Bernard-Soulier features a small number of large platelets, lifelong and without autimmunity being a factor. In ITP, the immune system destroys platelets and those that remain are often quite large. It's possible that you have only one of these, as both feature a diminished number of platelets and increased platelet size. Get a review by a good up-to-date hematologist. ...Read more
If the nuvaring caused ITP (I hear less then 1% can develop ITP from the ring), would removing it help? Or is ITP in me forever?
ITP is not infection:
I'm not sure what you are referring to.
Itp means idiopathic thrombocytoenic purpura and is a problem with an unexplained drop is someone's platelet count. It is felt to be autoimmune. There is a theory that it can be precipitated by a viral infection- especially in kids. I'm not sure if herpes virus has specifically been linked to itp in children, but I imagine that it could be. ...Read more
Not sure that I....: Understand your question, as it seems a bit circuitous. You say that you have been diagnosed with itp, which is characterized by a low PLT count. But then you ask if the "dip causes the lower count". Of course, that answer is yes, and is the reason for the itp diagnosis in the first place. If I'm misunderstanding your question, please clarify so that we can be more helpful. ...Read more
I'm 21 and ive been diagnosed with Chronic ITP since I was 4, can Chronic ITP cause infertility or prevent pregnancy or cause difficulty in ttc?
ITP and TTC: 21 year old lady with past medical history of Idiopathic Thrombocytopenia Purpura with concerns about infertility & pregnancy. Studies show women with ITP are able to conceive. Studies also show that women with ITP should be monitored closely before & during pregnancy. Most women have a normal pregnancy but some studies show worsening of platelet count yet ITP can be treated during pregnancy. ...Read more
Controversial: Association of infection agents including H.Pylori with ITP were suggested, but no direct prove. Results from H.Pylori and ITP were conflicting. Routine screening for H.Pylori in ITP patient is probably not recommended, because treating H.pylori in these pts does not improve platelet count. But, for severe refractory ITP, testing for H.Pylori can be considered. Response may be seen in these pts. ...Read more
Recently diagnosed with ITP (not stable) treated with eltrombopag (MMF didn't work) & have hypothyroidism. What tests can I do to find/rule out cause?
Cause for which one?: The ITP or the hypothyroidism? First I wish you get better and both conditions become controlled. The ITP as its name implies, has no specific reason that we know of, several theories, and is considered an auto-immune disease. Likewise is the hypothyroid disorder can be primary or secondary, but again often times no cause can be elicited. Keep the F/U with your hematologist and endocrinologist ...Read more
I have itp. Would this have been the cause of my miscarriage? And will this stop me carrying fullterm
It could have been: But it's really impossible to be certain one way or the other. The more important thing to address is the itp itself. You should work with your dr to address the cause and optimize your PLT count. When you decide to get pregnant, a hematologist should consult on your case and follow along during the pregnancy and delivery. Depending on the itp, your child could also be at risk b4 & after delivery. ...Read more
What cause platelet drop suddenly very low for days and then back to normal not in cyclic way? In ITP always low platelet right? No infection detected
Thrombocytopenia: Hello and welcome to HealthTap, there could be multiple causes of low Platelets. ITP by enlarge have low platelets but we may see normalisation periodically, remember it is diagnosis of exclusion. I would need more history from you also if you can share your blood work would be very helpful! Thank you :) ...Read more
Can azathioprine cause bruising? I am diagnosed with itp but never had brusing before. Only have it after taking prednisolene and azathiprine
Very very rare: It is possible for long standing sinus infections that are not treated with antibiotics to cause bone infections and spread into the brain causing meningitis. Itp, also called idiopathic thrombocytopenic purpura, is a rare disease in which the immune system destroys platelets. Viral infections and drugs can cause itp. Theoretically a viral infection causing sinusitis can cause itp. ...Read more
What can cause wbc 4.3 anc 0.710 MCHC 36.9 he was just treated in feb. For itp did a ivig? He is now 4month y the monitoring with frequent labs
Heme onc doc:
If platelets were low with diagnosis of ITP and now wbc are low with absolute neutrophil count of only 710, there is going to be a concern of cancer. If not already seen by hematologist, I would recommend evaluation by one ASAP.
Is his hemoglobin also low showing any sign of anemia? Any fevers or poor weight gain. If you would like to discuss this further, please request consult. ...Read more
Can flu cause a false high platelet count? I have ITP, last CBC shows 118 for platelets, even thought I'm bleeding from everywhere. Probably < 15 ATM.
Yes: Flu can cause either an increase in platelet count (thrombocytosis) or decrease in platelet count (thrombocytopenia). It causes much more thrombocytopenia than thrombocytosis. Its effect on platelet count is also age-dependent. Younger people tends to get an increased platelet count by flu infection, while elderly person tends to get decreaded platelet count by flu. ...Read more
My daughter is 9 with a history of itp. What would cause high WBC 21.80, low lymphocytes 3, high absolute# segs 20.3 and high neutrophil % 93?
Clubbed index and middle fingers. Chest xray 10 months ago. 26/f. No smoking. Should I be worried? IBS, ITP and hashimotos. Could these cause clubbing
ITP: Thrombocytopenia or low platelet level can be caused by so many things such as drugs, platelet consumption by clots, infections, vitamin deficiency, cancer related etc. Your doctor has to rule out all those possibilities and ultimately to do a bone marrow biopsy to eval bone marrow. See your md and discuss further re-diagnosis approach/treatment and other things you need to know re - itp. ...Read more
Symptom: Most of the time itp patients are asymptomatic and the only abnormality they have is the low platelet level on their blood counts. They can have bruising, tiny red dots on the skin, roof of the mouth etc- (ptechiae) or other type of bleeding such as bleeding in the gum, only if platelet level goes down really low-below 30k or so. ...Read more
Oral steroids: Idiopathic thrombocytopenic purpura is a condition in which autoimmune antibodies against platelets causes an increased rate of destruction. Platelets are needed for normal blood clotting. Heavy periods, nose bleeding, easy brusing, and a rash (purpura) may suggest this problem. Diagnosis requires a blood count and blood clottting studies. Treatment begins with steroids (prednisone). ...Read more
In most cases, itp in children resolves on its own. Your child’s blood may be tested weekly or at longer intervals until the platelet count has returned to normal.
Treatment may be recommended based upon the platelet count, age of the patient, activity level and bleeding symptoms. When treatment is recommended, it may involve the following medications that help keep platelet counts at a safe leve. ...Read more
Bruising, bleeding: People with itp may be at an increased risk of bruising or bleeding, depending on the platelet count and other factors, such as medications. If needed, itp can be treated with steroids or other medications. In some instances, removing the spleen (splenectomy) may be recommended. If you are to require surgery, the surgeon should be made aware of this condition. ...Read more
Good question: What treatments have you had? The medical treatments have typically included steroids, other immunosuppressive medications, rituximab. These medications do not always work, and sometimes they only work temporarily. The main surgical treatment is splenectomy. This does not always work either. The goal is to keep you platelets high enough so that you are not having frequent bleeding. Good luck. ...Read more
Probably not: The risks are (1) heavy bleeding during delivery and with epesiotomy or ceaserean section and (2) maternal antibodies against platelets crossing the placenta and affecting your newborn's platelet count. These are issues best discussed with your ob/gyn and hematologist. For more information try http://www. Mayoclinic. Com/health/idiopathic-thrombocytopenic-purpura/ds00844/dsection=complications. ...Read more
No: Both itp and ttp are diseases in which blood platelet counts fall however, itp typically leads to an increased risk for bleeding but ttp results in blood clot formation in small blood vessels. These clots can damage the kidneys or cause stroke. Both diseases can be treated with plasmaphoresis, a procedure in which anti-platelet antibodies can be removed from the blood (a temporary measure). ...Read more
Can be, but rare: Most people w/ treated itp can expect to live a normal life span. Platelets help the blood clot, so a person w/ extremely low platelets (due to immune system attack in itp) can have fatal bleeding esp in the brain. However, this happens <1% of the time. Your doctor will monitor your platelets, and there are many treatments for itp such as Prednisone that can help maintain a good platelet count. ...Read more
Most patients are able to recover platelet counts and have a mortality rate similar to the general population. For more details see this link.
http://bloodjournal. Hematologylibrary. Org/content/97/9/2549.long. ...Read more