Doctor insights on:
Cardiolipin Ab Ig G Igm
My results showed that I have antinuclear antibody on cardiolipin ab (igg). What are the implications?
I was told that even though My cardiolipin IgM has been high 3 times over a 100 each time since Nov. I should not worry because my IGG is normal.True?
Depends....: The anti-cardiolopin ab is a screening test; if (+) it does not necessarily mean you have a clinical disease. In addition, there are other tests that are thought to be more sensitive and specific for the diagnosis of antiphospholipid syndrome. Have you had the beta 2 glycoprotein test? Have you ever had 2 documented episodes of blood clots? If no clots and beta 2 (-), then "not to worry". ...Read more
Can you please explain the test for cardiolipin antibodies and what the numbers for IgG and IgM mean?
Auto-antibodies: Anti-cardiolipin antibodes are seen in some patients with auto-immune disease and in patients with syphilis. Igm antibodies mean recent onset of antibody production and igg means antibody production going on for a while. For details see these sites. http://www.nhlbi.nih.gov/health/health-topics/topics/aps/printall-index.html http://www.Mayoclinic.Com/health/antiphospholipid-syndrome/ds00921. ...Read more
My cardiolipin IgM has come back high 3x in Nov it was 133/Jan 82/ May 102ug/l IgG is 1.1U/ml. I have symptoms indicative to MCTD. My gp not worried?
Consider aspirin: IgM anticardiolipin antibodies have an intermediate chance of causing problems. They can be a sign of autoimmune disease including MCTD. If you have had no blood clots, miscarriages or problems from this antibody it is often treated with an Aspirin a day. You should talk this over with your doctor. ...Read more
Tested for anti cardiolipin IgM is negative(0.7) but IgG is positive (54.8) normal range of lupus anticoagulant, protein S and protein C activity help?
ANA via ELISA 74 units, strong positive (negative via IFA)
Anti-Cardiolipin IgG 22 CU, moderate positive
Short answer is : Needing more info on labs and clinical symptoms. ANA positive is sensitive for possible autoimmune disease.but not very specific. Every lab on your ENA panel is important esp they are moderate positive and they all mean something different. Lab is never enough for diagnosis esp rheumatic condition. It is important for you to find a rheumatologist for thorough history and physical exam. ...Read more
Bilateral upper extremity weakness nerve damage in toes. Started 5 months ago progressing. ESR 31mml Ana 1:640 homogenous cardiolipin IgG 33gpl ?
Positive ANA of 1:80 homogenous and Cardiolipin AB IGM of 17mlp. Labs drawn on accident. No symptoms. Should I be concerned? What could it be?
How do you feel?: Most people who have this discovered incidentally never have problems. ...Read more
See below: Both of these are low values and should not be used for a specific diagnosis. However, the most important feature is why were these labs drawn. For example what symptoms you were having to have the labs drawn and in that case they may mean slightly more, but just looking at the labs they are low values and dont point to one specific disease. ...Read more
My anti-cardiolipin IgM 133u/ml(nov), 82u/ml(feb). Who do I need to see with regards to this? What speciality.
My anti-cardiolipin IgM was checked to rule out mctd. It was in nov 133 / 82 in jan & in feb it came down to 9.38. Does it need to be tested again?
See details: Anticardiolipins never rule in or rule out mctd. They are used to diagnosis specific clotting disorders that can be associated with connective tissue disorders. The levels of anticardiolipins vary up and down and in your case they should be checked once or twice a year, not every month or two. I would urge taking an 81 mg asa daily as protection if your doctor agrees. ...Read more
My anti-cardiolipin IgM was in nov 133u/ml, 31st jan 82u/ml and on the 4th feb it came down to 9.38 mpl. Can it drop that much in 5 days? Is it error?
Anti-cardiolipin IgM was checked as part of tests for mctd. It was 133 nov / 82 in jan & in feb it was 9.38. Gp says there no needs to refer or treat?
? Referral: To have anti-phospholipid antibody syndrome you need to have 2 positive tests at least 3 months apart. Transient elevations are common and not risky. It's unusual that the first test was so high and it did not persist. If you still have other mctd symptoms you should see a rheumatologist. ...Read moreSee 1 more doctor answer
My anti-cardiolipin IgM was in nov 133 / 82 in jan & in feb it came down to 9.38. Should i still be referred & do I need it checked again if so when?
Ask first: Ask first why the test is being run. If there is a suspected blood clotting disorder, yes, you should see a specialist such as a hematologist. If there is an autoimmune disease process, you should see a rheumatologist. If neither of these apply, then question why the test is being run. ...Read more
I am being tested for Lupus my APTT ratio was 1.16 slightly raised and my cardiolipin IGM was 102ug/l ESR raised but ANA was normal.
Need more data : This will depend on more information that I have at this point. then ANA could be negative if only a binding essay was used rather than an immunofluorescent assay. You may fulfill criteria for lupus anticoagulant . You will need to have your physician clarify these tests which Lab did them and how accurate they are. ...Read more
Can I still have lupus if my ANA and other antibodies are negative except the cardiolipin IgM and lupus coagulant! I have all the symptoms for lupus.
Yes,amongst other Dx: Anti-cardiolipin antibodies are antibodies often directed against cardiolipin & found in several diseases, including syphilis,antiphospholipid syndrome,livedoid vasculitis, vertebrobasilar insufficiency,Behçet's syndrome,idiopathic spontaneous abortion,] and systemic lupus erythematosus(SLE).They are a form of anti-mitochondrial antibody. In SLE,anti-DNA Abs &anti-cardiolipin Abs act independently ...Read more
My cardiolipin IgM have been high since Nov(133,82 & 102ug/l) Gp dismisses further Action, Aspirin or tests. My neutrophils are also high at 7.63.
Needs eval: needs further investigation and likely rx. Rheumatologist shoul help ...Read more
My anti-cardiolipin IgM was in nov 133u/ml, jan 82u/ml and on the feb it came down to 9.38 mpl. Pt 13.8 ptt 31.2 hypermobility of the joints. Normal?
Maybe: Having an anticardiolipid become positive is always concerning. I am glad it was repeated and came down. With that said an evaluation from a hematologist would be a good next step, as there are many other things to consider that go far beyond the scope of this forum. ...Read more