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Doctor insights on: Carbidopa Levodopa Maximum Dosage

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What is the typical dosage of sinemet (carbidopa and levodopa) cr?

What is the typical dosage of sinemet (carbidopa and levodopa) cr?

Sinemet-CR: This has to be determined by careful titration thru your doctor. Initial dose is usually 50-200. Consult your Neurologist. ...Read more

Carbidopa (Definition)

Dopamine is a necessary neurotransmitter in the basal ganglia of our brains, and in parkinson's, there is a deficiency. We supplement l-dopa, to replace, but since the body might break down our oral med, we add Carbidopa which prolongs the benefit ...Read more


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What is the maximum dosage per day for Sinemet (carbidopa and levodopa) tablets?

What is the maximum dosage per day for Sinemet (carbidopa and levodopa) tablets?

Variable, but: In my experience, the maximum Sinemet (carbidopa and levodopa) dosing is the 25/250 tab four times daily, and if this seems to wear off, one can add Comtan (entacapone). Problem with going too high with L-DOPA is incidence of dyskinesias. ...Read more

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Milligrams for 6 hour sinemet (carbidopa and levodopa)? What is the dosage for this medication?

Milligrams for 6 hour sinemet (carbidopa and levodopa)? What is the dosage for this medication?

Dosages: Dosages are adjusted for the specific needs of each patient - there is no standard dose for any specific time period. Sinemet (carbidopa and levodopa) comes in carbadopa-levodopa doses of 10-100, 25-250, and 25-100. These can be combined and given at various times throughout the day to best relieve the symptoms of parkinson's disease. If you are not sure of your dose or the dose of someone you are caring for, you need to call the doctor that prescribed the medication to clarify. Good luck! ...Read more

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Which is more likely to increase psychoses. Increasing stalevo (carbidopa and levodopa and entacapone) from 125 to 150 on the same schedule or changing the dosage from 6 to 7 per day?

Which is more likely to increase psychoses. Increasing stalevo (carbidopa and levodopa and entacapone) from 125 to 150 on the same schedule or changing the dosage from 6 to 7 per day?

Less risk by inc frq: In the treatment of Parkinson's patients with Sinemet (carbidopa and levodopa) it is generally believed that increased frequency of medication dosage is preferable for a variety of reasons including less risk of precipitating psychoses by the medication. Having said that-the most honest answer is "you will never know until you try it." ...Read more

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When switching from regular Sinemet (carbidopa and levodopa) to CR, do you need to add little more CR to achieve the same dose of the regular Sinemet (carbidopa and levodopa)?

When switching from regular Sinemet (carbidopa and levodopa) to CR, do you need to add little more CR to achieve the same dose of the regular Sinemet (carbidopa and levodopa)?

Not usually: You can usually use the same dose of Sinemet (carbidopa and levodopa) CR as you had of the regular Sinemet (carbidopa and levodopa). You may not feel it "kick in" as strongly but it should work just as effectively and hopefully last longer for you. Good luck. ...Read more

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What is the typical Sinemet (carbidopa and levodopa) dose for a patient after DBS?

What is the typical Sinemet (carbidopa and levodopa) dose for a patient after DBS?

Depends...: Regretfully, there is no typical Sinemet (carbidopa and levodopa) dose following DBS, given that each patient is different and their need for treatment varies. Discuss this with your neurologist. ...Read more

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What is the starting dose of Sinemet (carbidopa and levodopa) per day for Parkinsons?

What is the starting dose of Sinemet (carbidopa and levodopa) per day for Parkinsons?

Typical- Misnomer...: Quite honestly, as a neurologist I've found LESS AND LESS TYPICAL starting doses of any of the anit-parkinsonian medications as I get farther into my career. Oh, sure there are textbook numbers but when the actual DIAGNOSIS of PD cannot be firmly made at times for years after presentation should there really be such as a thing as a TYPICAL starting dose of Sinemet (carbidopa and levodopa)? Commonly seen is 25/100 3x/day. ...Read more

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Parkinsons - Is it true that the bioequivalent dose of Sinement CR is 75-80% of the regular Sinemet (carbidopa and levodopa)?

Answer varies: The bioequivalent dose actually depends on the dose that is needed, your metabolism, what other medicines you use, an your experience with these medicines.

The ratio of sinemet (carbidopa and levodopa) CR to regular sinemet (carbidopa and levodopa) may vary from 50% to 100% of the regular dose. Your number (75%) is right inbetween.

For 600 mg regular sinemet (carbidopa and levodopa), most would start with 300 mg sinemet (carbidopa and levodopa) CR. ...Read more

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Why is Sinemet (carbidopa and levodopa) CR is inferior to regular Sinement in terms of strength even though they carry the same mg in terms of dose for Parkinsons?

Why is Sinemet (carbidopa and levodopa) CR is inferior to regular Sinement in terms of strength even though they carry the same mg in terms of dose for Parkinsons?

Different timing: CR is sustained release. Regular lasts only a few hours and tends to have more peaks and troughs. One can use both. Regular is given 3 to 4 times a day. ...Read more

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What is the typical starting dose of sinemet (carbidopa and levodopa) for a patient with parkinsons? How long do you need to take it feel its effects? Several weeks?

What is the typical starting dose of sinemet (carbidopa and levodopa) for a patient with parkinsons? How long do you need to take it feel its effects? Several weeks?

Varies: Different movement disorder neurologists have varying treatment regimens, but I prefer to start sinemet (carbidopa and levodopa) at low dosing initially, such as 10/100 3-4 times daily in divided dosing. With your dbs, the regimen may require a different plan. ...Read more

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How does the drug carbidopa affect levodopa?

How does the drug carbidopa affect levodopa?

Blocks breakdown: Carbidopa acts to block the enzyme aromatic-l-amino-acid decarboxylase which converts l-dopa to dopamine. Since it cannot get into the brain it works in the rest of the body (periphery). When given in combination with l-dopa in parkinson's disease, it inhibits the conversion of l-dopa to Dopamine in the body so that more is available to be converted in the brain where it is needed. ...Read more

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What happens if I take carbidopa and levodopa?

What happens if I take carbidopa and levodopa?

See below: Carbidopa-levodopa is a generic medication for Parkinson's disease and helps dopamine brain connections. Why would you want to take this if you do NOT have Parkinson's?? ...Read more

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Please describe the medication: sinemet (carbidopa and levodopa)?

Please describe the medication: sinemet (carbidopa and levodopa)?

Carbidopa/levodopa: Sinemet (carbidopa and levodopa) is a combination drug that contains Carbidopa and levodopa. It is most commonly prescribed for parkinson's disease but may also be prescribed for other conditions including restless legs syndrome. ...Read more

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What does sinemet (carbidopa and levodopa) consist of and what is cr?

What does sinemet (carbidopa and levodopa) consist of and what is cr?

See below: Sinemet® (carbidopa-levodopa) is a combination of Carbidopa and Levodopa for the treatment of parkinson's disease and syndrome. Sinemet® cr (carbidopa-levodopa) is a sustained-release combination of Carbidopa and Levodopa for the treatment of parkinson's disease and syndrome. ...Read more

Dr. Alan Ali Dr. Ali
2 doctors agreed:
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What can you tell me about the drug sinemet (carbidopa and levodopa)?

Dr. Alan Ali Dr. Ali
2 doctors agreed:
What can you tell me about the drug sinemet (carbidopa and levodopa)?

Sinemet (carbidopa and levodopa): Combination of Levodopa & Carbidopa, for treating Parkinson's disease ...Read more

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I took 9 sinemet (carbidopa and levodopa) tablet a day, is that to much?

Sinemet (carbidopa and levodopa): Not sure what milligram each, but if that's what your doctor prescribed & your symptoms are under control & you are tolerating the medication well, then you should be ok. ...Read more

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Is generic sinemet (carbidopa and levodopa) cr is not effective as the branded version?

Is generic sinemet (carbidopa and levodopa) cr is not effective as the branded version?

It depends: Because of cost considerations its worth trying it for a while. Watch for peak dose dyskinesis and dose failures or wearing off. ...Read more

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Can I get levadopa without the carbidopa that's added in sinemet (carbidopa and levodopa)?

Not wise: The Carbidopa is there to prolong the effect of the L-DOPA, and without it the medication benefit will be very brief and needs to be taken several more times daily. ...Read more

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Which is more potent sinemet (carbidopa and levodopa) or the generic of carbidopa/levodopa?

Neither: Generic drugs are held to standards where the manufacturer must prove "bioequivalence" to the branded drug. The molecules must be structurally the same, and the same standard of quality and purity must be met. The pills and the packaging themselves may look different, but the active ingredient is the same. It can be thought of as the difference between clorox bleach and safeway brand bleach. ...Read more

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On sinemet (carbidopa and levodopa) 2 times per day 62.5. I want off this to try other alternatives first how do I safely do this. I do not agree with my diagnosis of pd.?

On sinemet (carbidopa and levodopa) 2 times per day 62.5. I want off this to try other alternatives first how do I safely do this. I do not agree with my diagnosis of pd.?

See your doctor: If you can't find any common ground then it's best to part ways and find a physician you feel mors comfortable with. That said, you should negotiate a time period during which you can try alternatives before resuming orthodox therapy. Your doctor will help wean you. ...Read more

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What is the recommended taper schedule when discontinuing sinemet (carbidopa and levodopa)?

Slowly: Depends on dosing/schedule, but its very important to taper very slowly. It would be best to call your prescribing doctor and have them give you a clear tapering schedule. ...Read more

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My neurologist put me on carbidopa + levodopa for my Parkinson's symptoms. What should I expect?

My neurologist put me on carbidopa + levodopa for my Parkinson's symptoms. What should I expect?

Improvement: This medine works best for stiffness, then slowness of movement, then tremor. You need to be monitored for effectiveness and side effects by your doctor. ...Read more

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How do you wean off sinemet (carbidopa and levodopa)?

Slow taper: If sinemet (carbidopa and levodopa) needs to be stopped, depending on the amount and indication for the medication, the most desire able way is to taper the medication. Parkinson's patients can have severe side effects if sinemet (carbidopa and levodopa) is abruptly stopped. ...Read more

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Can rhodiola interact with sinemet (carbidopa and levodopa)?

Probably not bad: I had to look up rhodiola as that was one I had never heard of. There are no reasons, at least theoretically, that the two should be a problem. I did a literature search and there are no articles in the medical literature looking at rhodiola and sinemet (carbidopa and levodopa). There are some laboratory papers that suggest rhodiola should be helpful in pd, but I could not find any clinical studies in people. ...Read more

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Can sinemet (carbidopa and levodopa) block dystonic reactions caused by haloperidol?

Can sinemet (carbidopa and levodopa) block dystonic reactions caused by haloperidol?

Yes: This is one of the medications that can be used. Benztropine (cogentin), amantadine, or even Benadryl (diphenhydramine) are used more often. ...Read more

Levodopa (Definition)

A drug which when it gets into the brain is converted to Dopamine that ...Read more