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Doctor insights on: Carbidopa Levodopa And Entacapone Side Effects

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Carbidopa (Definition)

Dopamine is a necessary neurotransmitter in the basal ganglia of our brains, and in parkinson's, there is a deficiency. We supplement l-dopa, to replace, but since the body might break down our oral med, we add Carbidopa which prolongs the benefit ...Read more


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Which is more likely to increase psychoses. Increasing stalevo (carbidopa and levodopa and entacapone) from 125 to 150 on the same schedule or changing the dosage from 6 to 7 per day ?

Which is more likely to increase psychoses. Increasing stalevo (carbidopa and levodopa and entacapone) from 125 to 150 on the same schedule or changing the  dosage from 6 to 7  per day ?

Less risk by inc frq: In the treatment of Parkinson's patients with Sinemet (carbidopa and levodopa) it is generally believed that increased frequency of medication dosage is preferable for a variety of reasons including less risk of precipitating psychoses by the medication. Having said that-the most honest answer is "you will never know until you try it." ...Read more

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Does the use of the neupro patch and stalevo (carbidopa and levodopa and entacapone) 125 lessen the incidence of psycosis ?

Does the use of the neupro patch and stalevo (carbidopa and levodopa and entacapone) 125 lessen the incidence of psycosis ?

Parkinson's Disease: These are both medications used to treat parkinson's disease, not psychosis. Some antipsychotic medications can induce parkinsonism in movements -- not true parkinson's disease. Sometimes these meds used to treat parkinson's may cause psychotic symptoms. Late-stage parkinson's disease can also involve a type of dementia with hallucinations as well. ...Read more

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What is the difference between Parkinson's drug sinemet and stalevo (carbidopa and levodopa and entacapone)?

What is the difference between Parkinson's drug sinemet and stalevo (carbidopa and levodopa and entacapone)?

COMT inhibitor: Entacaptone is a selective catecholamine-o methyl transferase (comt) inhibitor that increases the bioavailabilty of dopamine. Like Carbidopa in sinemet it does not cross the blood brain barrier. Stalevo (carbidopa and levodopa and entacapone) is a combination of l dopa, Carbidopa and entacaptone. Sinemet is a combination of Carbidopa and l-dopa. ...Read more

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Is Stalevo (carbidopa and levodopa and entacapone) superior to Sinemet for Parkinson’s? Is one better than the other?

Is Stalevo (carbidopa and levodopa and entacapone) superior to Sinemet for Parkinson’s? Is one better than the other?

Superiority?: All of the drugs in this class attempt to increase the levels of circulating dopamine. Sinemet is a combination of 2 drugs whereas Stalevo (carbidopa and levodopa and entacapone) is a combination of 3. There is currently an ongoing study at the Mayo Clinic to answer this question - but right now - there isn't any data to demonstrate if one is 'better' than the other. The best treatment is the one that works for you. Hope that helps! ...Read more

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Taking Stalevo (carbidopa and levodopa and entacapone) 125X6, Requip 6mg X2. What sinus medicine can I take?

Hard to know: Are you referring to prescription medication or over the counter formulations? Do you have a specific one in mind? You can also ask your local pharmacist and they should be able to help you answer this question. ...Read more

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Dr. Pappas...Compared to 5 x 3 mg of requip & 6x 125 stalevo (carbidopa and levodopa and entacapone) will 8mg neupro & 6x 125 stalevo (carbidopa and levodopa and entacapone) be less likely to cause psycosis ?

Dr. Pappas...Compared to 5 x 3 mg of requip & 6x 125 stalevo (carbidopa and levodopa and entacapone) will 8mg neupro & 6x 125 stalevo (carbidopa and levodopa and entacapone) be less likely to cause psycosis ?

Variable: Hello -- great question -- and you're basically asking about the difference between Neupro (rotigotine) ; requip. The data i've seen shows that Neupro (rotigotine) had a 7-14% incidence of hallucinations in clinical trials. This effect was dose-related, also. Requip had 5% incidence of hallucinations. Results may vary by individual too. I'll refer this question to some neurology colleagues for input also. Thanks. ...Read more

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Does seroquel or escitalipram interfere with stalevo (carbidopa and levodopa and entacapone) and/or requip?

Does seroquel or escitalipram interfere with stalevo (carbidopa and levodopa and entacapone) and/or requip?

Parkinson's psych meds: Main risks are ekg changes with Lexapro (escitalopram) and seroquel that should be monitored, and an increased risk of lowered blood pressure upon standing with the seroquel and requip. Best wishes. ...Read more

Levodopa (Definition)

A drug which when it gets into the brain is converted to Dopamine that ...Read more