Doctor insights on:
Carbidopa And Levodopa Adverse Effects
What is the typical starting dose of sinemet (carbidopa and levodopa) for a patient with parkinsons? How long do you need to take it feel its effects? Several weeks?
Sinemet-CR: This has to be determined by careful titration thru your doctor. Initial dose is usually 50-200. Consult your Neurologist. ...Read more
See below: Sinemet® (carbidopa-levodopa) is a combination of Carbidopa and Levodopa for the treatment of parkinson's disease and syndrome.Sinemet® cr (carbidopa-levodopa) is a sustained-release combination of Carbidopa and Levodopa for the treatment of parkinson's disease and syndrome. ...Read moreSee 1 more doctor answer
Sinemet (carbidopa and levodopa): Not sure what milligram each, but if that's what your doctor prescribed & your symptoms are under control & you are tolerating the medication well, then you should be ok. ...Read more
Yes: But the GI side effects would make it intolerable. ...Read more
It depends: Because of cost considerations its worth trying it for a while. Watch for peak dose dyskinesis and dose failures or wearing off. ...Read more
Neither: Generic drugs are held to standards where the manufacturer must prove "bioequivalence" to the branded drug. The molecules must be structurally the same, and the same standard of quality and purity must be met. The pills and the packaging themselves may look different, but the active ingredient is the same. It can be thought of as the difference between clorox bleach and safeway brand bleach. ...Read more
Dosages : Dosages are adjusted for the specific needs of each patient - there is no standard dose for any specific time period. Sinemet (carbidopa and levodopa) comes in carbadopa-levodopa doses of 10-100, 25-250, and 25-100. These can be combined and given at various times throughout the day to best relieve the symptoms of parkinson's disease. If you are not sure of your dose or the dose of someone you are caring for, you need to call the doctor that prescribed the medication to clarify. Good luck! ...Read more
On sinemet (carbidopa and levodopa) 2 times per day 62.5. I want off this to try other alternatives first how do I safely do this. I do not agree
with my diagnosis of pd.?
See your doctor: If you can't find any common ground then it's best to part ways and find a physician you feel mors comfortable with. That said, you should negotiate a time period during which you can try alternatives before resuming orthodox therapy. Your doctor will help wean you. ...Read moreSee 1 more doctor answer
When switching from regular Sinemet (carbidopa and levodopa) to CR, do you need to add little more CR to achieve the same dose of the regular Sinemet (carbidopa and levodopa)?
Slowly: Depends on dosing/schedule, but its very important to taper very slowly. It would be best to call your prescribing doctor and have them give you a clear tapering schedule. ...Read more
Before I take Stalevo, (carbidopa and levodopa and entacapone) I'm on but shortly after, I suddenly go off. What's causing this ?
See a physician: Your questions is not very clear, but is important to see your doctor for accurate reason for your symptoms ...Read more
Slow taper: If sinemet (carbidopa and levodopa) needs to be stopped, depending on the amount and indication for the medication, the most desire able way is to taper the medication. Parkinson's patients can have severe side effects if sinemet (carbidopa and levodopa) is abruptly stopped. ...Read more
Probably not bad: I had to look up rhodiola as that was one i had never heard of. There are no reasons, at least theoretically, that the two should be a problem. I did a literature search and there are no articles in the medical literature looking at rhodiola and sinemet (carbidopa and levodopa). There are some laboratory papers that suggest rhodiola should be helpful in pd, but i could not find any clinical studies in people. ...Read more
Typical- Misnomer...: Quite honestly, as a neurologist I've found LESS AND LESS TYPICAL starting doses of any of the anit-parkinsonian medications as I get farther into my career. Oh, sure there are textbook numbers but when the actual DIAGNOSIS of PD cannot be firmly made at times for years after presentation should there really be such as a thing as a TYPICAL starting dose of Sinemet (carbidopa and levodopa)? Commonly seen is 25/100 3x/day. ...Read more
Sometimes: Sinemet (carbidopa and levodopa) should be tapered slowly over many weeks to months foll. The combination of DBS and meds usually works better than either alone. There may be some sinemet (carbidopa and levodopa) reduction with a single DBS, and even more with a second DBS. The target allowing the most med reduction is STN. Every patient needs a different approach and everyone is different so it is hard to say how much it can be reduced. ...Read more
May: help symptoms associated with parkinson diseaseGet a more detailed answer ›
No: not without increasing other side effectsGet a more detailed answer ›
Could be: If the medicine was very soft, you may wonder if it had normal activity. This is not a common situation, and it is hard to answer your question. It sounds as if the pills were damaged at least. It is best to discard damaged pills and replace them. ...Read more
For a Parkionson patient with DBS - what are the indications that your body needs more Dophamine via Sinemet (carbidopa and levodopa)?
See neurologist!: This is a very specialized question and the answer is not a simple one DBS is carried out on patients who originally rsspoded to DOPAMINE but after a number of years with increasing dosage started to get complication of the drugs as well as reduced efficacy It cannot be dealt with with a one size fits all answer ...Read more
Which is more likely to increase psychoses. Increasing stalevo (carbidopa and levodopa and entacapone) from 125 to 150 on the same schedule or changing the dosage from 6 to 7 per day ?
Less risk by inc frq: In the treatment of Parkinson's patients with Sinemet (carbidopa and levodopa) it is generally believed that increased frequency of medication dosage is preferable for a variety of reasons including less risk of precipitating psychoses by the medication. Having said that-the most honest answer is "you will never know until you try it." ...Read more
No,New LifestyleWill: No, but creating a new lifestyle that you enjoy will:eat every3hr.Every 3hr:eat a palm-sized portion low fat protein+complexcarb (1/2cbrwnrice, 1/2c brnpasta, 1pcbrwnbred, or4crackers).Per day:sprinkle 4fruits/day, 5veggies/day, 3tbsbuttr/vegoil.Walk everywhere u can, 80-100ozwater/day(add a squeeze citrus).Join online support (like thebiggestloser.Com)to keep you motivated. ...Read more
Very safe: This medicine has been out for forty years and has been a miracle drug for pd patients. There are potential issues for people who have been on it for a long time or at high doses (ie fluctuations, dyskinesias), but nearly every pd patient who goes on it feels better. It will not damage your liver, kidneys or any other organ. Because of the above issues, it may not be the first med used in pd. ...Read moreSee 1 more doctor answer
What is the recommended amount of sinemet (carbidopa and levodopa) to be taken for Parkinson's disease?
Sinemet (carbidopa and levodopa): Sinemet (carbidopa and levodopa) is the most effective medication in the treatment of motor symptoms of pd. Dose varies from patient to patient. Is not usually my first line of therapy in young patients unless all other options have failed. Typically start on 25/100 three times a day and adjust depending on patient's needs and response. I have few patients on only 1/2 pill twice a day and many more on 16 pills a day. ...Read more
Does the use of the neupro patch and stalevo (carbidopa and levodopa and entacapone) 125 lessen the incidence of psycosis ?
Parkinson's Disease: These are both medications used to treat parkinson's disease, not psychosis. Some antipsychotic medications can induce parkinsonism in movements -- not true parkinson's disease. Sometimes these meds used to treat parkinson's may cause psychotic symptoms. Late-stage parkinson's disease can also involve a type of dementia with hallucinations as well. ...Read more
Parkinsons - Is it true that the bioequivalent dose of Sinement CR is 75-80% of the regular Sinemet (carbidopa and levodopa)?
Answer varies: The bioequivalent dose actually depends on the dose that is needed, your metabolism, what other medicines you use, an your experience with these medicines. The ratio of sinemet (carbidopa and levodopa) CR to regular sinemet (carbidopa and levodopa) may vary from 50% to 100% of the regular dose. Your number (75%) is right inbetween. For 600 mg regular sinemet (carbidopa and levodopa), most would start with 300 mg sinemet (carbidopa and levodopa) CR. ...Read more
How often sinemet (carbidopa and levodopa) is usually taken in a maintenance dose? Is it 3 times or 4 times per day for parkinsons?
This depends: On symptoms - your pcp has answer for you in particular. ...Read more
Does a reduction in Sinemet (carbidopa and levodopa) to 300mg per day from 550mg after DBS STN considered too aggressive or sub-therapeutic?
Check with doc : Please make sure to check with your neurologist before making such changes. He or she is specially trained in this. ...Read more
Why is Sinemet (carbidopa and levodopa) CR is inferior to regular Sinement in terms of strength even though they carry the same mg in terms of dose for Parkinsons?
I take requip & stalevo (carbidopa and levodopa and entacapone) 6 times a day. Sometimes i can see improvement and other times i can't. How can I insure that the meds are absorbed every time?
Take meds: Take meds before meals, about 1/2 hour before. ...Read more
I have been on sinemet (carbidopa and levodopa) for years for dopa responsive dystonia. It has resolved all my symptoms. I am 60 yr old and I am considering botux injections for wrinkles. Would the botux affect my drd?
Yes can be a problem: Botox is what is known as an anticholinergic medication. The combination between Dopamine (or perhaps in your case sinemet (carbidopa and levodopa) or carbidopa/levodopa) can actually either enchance or reduce the activity of the dopamine. Botox can also exacerbate the condition known as tardive dyskinesia because of its ability to deplete stores of Dopamine in the brain. ...Read moreSee 1 more doctor answer
What is the protocol for switching a Parkinson’s patient from regular Sinemet (carbidopa and levodopa) to Sinemet (carbidopa and levodopa) CR?
Slow increase: Sinemet (carbidopa and levodopa) CR is a 2x/day treatment vs Sinemet (carbidopa and levodopa) at 4x/day, so to get to twice the daily dose you need to increase dosing slowly over several days, up to a week. I suggest you talk to your doctor, who can nap out a plan to do this safely ...Read more
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