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Doctor insights on: Carbamazepine And Metabolite

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What is the difference between carbamazepine and carbamazepine 10-11 expoxide?

What is the difference between carbamazepine and carbamazepine 10-11 expoxide?

Active metabolite: When Carbamazepine is metabolized in the body a chemical substance known as a 10, 11 epoxide forms which is the active metabolite that prevents seizures from initiating in the brain. ...Read more

Dr. Mohamad Mikati
433 doctors shared insights

Carbamazepine (Definition)

This drug was once the breakthrough product to treat trigeminal neuralgia, and later various forms of epilepsy, and even psychiatric uses ...Read more


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My brother has fits for last12 yrs he is on diva-d750 twice and tegretol twice and firisium onc for last 6 months can he drive n work normally.

Probably not: Driving is a significant risk for him and others if his seizures are uncontrolled. Typically, patients with active epilepsy are advised to avoid driving, operating power equipment, doing activities at heights, and swimming or taking baths alone. ...Read more

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Is it dangerous to suddenly stop taking carbamazepine 800mg and venlafaxine 150mg?

Yes: There could be an uncomfortable discontinuation syndrome. It would be safer and more comfortable. ...Read more

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Safe amount of acetaminophen a day if I take a Trileptal 1200 mg/day a know inducer of CYP (increased toxic acetaminophen metabolite)?

Safe amount of acetaminophen a day if I take a Trileptal 1200 mg/day a know inducer of CYP (increased toxic acetaminophen metabolite)?

After research: Checked in epocrates which is a respected source of drug information showed nothing in the way of interaction between acetaminophen and trileptal. before taking any action check with your doctor and or pharmacist. Good luck ...Read more

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Tegretol for painful hands, is this okay?

Tegretol for painful hands, is this okay?

Unusual: Choice listen to your doc....Depends on source of pain. ...Read more

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Got diagnosed with MS & doctor perscribed me carbamazepine, noticed my jaw started hurting after taking it. Doctor said it'll go away after 2 weeks ?

Got diagnosed with MS & doctor perscribed me carbamazepine, noticed my jaw started hurting after taking it. Doctor said it'll go away after 2 weeks ?

Trigeminal neuralgia: Perhaps your doctor was thinking you might have trigeminal neuralgia. This medicine is often used to prevent the pain of this condition. It does not cause jaw pain. Some people feel relief sooner than 2 weeks with this medicine. Other treatments may be gabapentin, tramadol, and amitriptyline, when this medicine does not help. ...Read more

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I have low sodium on tegretol. Any solutions without going off tegretol?

I have low sodium on tegretol. Any solutions without going off tegretol?

Depends on level: Depends on how low your serum sodium is on routine testing, if you are slightly low, then you probably don't need to do anything. If your sodium levels are in the 120's, increasing your salt intake may improve your values, but this will be your new diet. There are many new anticonvulsants that treat event related epilepsy that do not produce salt wasting, and have fewer side effects than tegretol. ...Read more

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How safe is Tegretol?

How safe is Tegretol?

Tegretol: Common are nausea, headache, rash, ataxia, anemia, effect on liver. Safe if monitor blood levels & other metabolic parameters. ...Read more

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Can tegretol cause anxiety?

Can tegretol cause anxiety?

Possibly: Theoretically yes as it does have central nervous system effects. More notable side effects include sedation, dizziness, confusion, unsteadiness, nausea, and even headache - all of which can contribute to a feeling of anxiety as well. ...Read more

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Can carbamazepine cause glaucoma?

Can carbamazepine cause glaucoma?

Maybe: Tegretol is an anti-cholinergic medication and may cause acute pressure increases in those with narrow anatomical drainage angles (closed angle glaucoma). It is generally safe in patients with open-angle glaucoma but should be observed closely. ...Read more

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Do all ssri's raise tegretol levels?

Yes: So the short answer is yes, but different SSRIs inhibit different parts of the bodies drug breakdown mechanism. Thus, some will increase the levels more than others. Also everyone is a bit different. It is like that lexapro (escitalopram) has the least interactions in this way. ...Read more

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Does carbamazepine intreract with milk?

No: there is no data to suggest that milk affects the absorption of bioavailability of carbamazepine ...Read more

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What are the side effects of carbamazepine?

Many: We see drowsiness, dizziness, nausea, even occas vomiting, blurry vision, general fatigue, and rarely, liver toxicity, bone marrow suppression with anemia, poor blood clotting, and even elevation of cholesterol. ...Read more

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Side effects of tegretol over several years?

Side effects of tegretol over several years?

Tegretol: It can lower thyroid function, increase anti-diuretic hormone, rarely rashes or absence seizures or low blood count. ...Read more