Doctor insights on:
Helps: Xeloda, (capecitabine) is an orally-administered chemotherapeutic agent used in the treatment of numerous cancers including colorectal Ca. Capecitabine is a prodrug, that is enzymatically converted to 5-fluorouracil in the body and is employed as a form of adjuvant therapy that may help to enhance survival. In the face of metastasis, with combination drugs it may prolong survival by months. ...Read more
How fast does Xeloda (capecitabine) work on shrinking tumours and how would this drug cause you to vomit blood ?
Mcrc patient aged 65. Drs not willing to
Give any 5-FU drugs due to chest tightness . Tried Xeloda (capecitabine) n irinotecan . What can we do now ?
Define met site.: Regardless of site and extent of mets, primary resection essential. This eliminates any other site of spread. PET/CT will determine met areas after primary removed. If as is usual, mets are to liver, microwave ablation, or chemo embolization or radioactive microspheres given to liver to control disease. Any pulmonary nodes removed thru thorascope. Most protocols contain 5FU (fluorouracil). ...Read more
Can any targeted therapies or other drugs help with metastic colon cancer when Xeloda (capecitabine) n irinotecan has failed ?
Yes: Target agents that have activity either as single agent or as combination for recurrent or refractory metastatic colon cancer as a second line include: Avastin (bevacizumab) or Cetuximab/Panitumumab (if k-ras, n-ras, b-raf are wide type) or Regorafenib (inhibitor of angiogenic receptor) or aflibercept. FOLFOX may be effective too after irinotecan has failed. Clinical trials are aslo available. ...Read more
70 years male with stomach cancer metastasized to liver and bone, is this a good chemo drug combination (capecitabine+oxaliplatin+zoledronic acid)?
Chemo : If you can tolerate capecitabine, the regiment will be good for the type of cancer. Also, consider to check her2-neu receptor status of the cancer - as if her2-neu receptor is positive, Herceptin (trastuzumab) which is an inhibitor to the her2-neu receptor should be considered as one of treatment options. ...Read moreSee 1 more doctor answer
An Oral Chemotherapy: Xeloda (capecitabine) is an oral chemotherapy drug, the most common side effects are diarrhea, nausea, hand-foot syndrome (redness, swelling, cracking of palms/soles) and like any chemotherapy may bring down your white blood cells. To prevent this you may take an anti diarrheal, anti emetic, b6, use a skin moisturizer and check your blood frequently. Not everyone experiences one of these symptoms. ...Read more
In certain cancer: Xeloda (capecitabine) is an oral chemo, which is a prodrug of 5-fluorouracil- a type of chemotherapy that has been used for many different cancers. Xeloda (capecitabine) is an effective chemotherapy for some cancers- such as gastrointestinal cancers ( colon, rectal, stomach, esophageal etc), breast cancer- but not for all type of cancer. ...Read more
Varies: This varies among different patients. Half of the active drug is eliminated in approx 45 minutes from thebody- however, some drug levels are present in body tissues for many days. ...Read more
Possible Side Effect: Xeloda (capecitabine) is an oral chemotherapy drug, the most common side effects are diarrhea, nausea, hand-foot syndrome (redness, swelling, cracking of palms/soles) and like any chemotherapy may bring down your white blood cells. To prevent this you may take an anti diarrheal, anti emetic, b6, use a skin moisturizer and check your blood frequently. Not everyone experiences one of these symptoms. ...Read more
Four companies..: Sorry to hear that you will need xeloda (capecitabine)..I assume you have colon cancer? True dpd is quite rare and so routine screening is not recommended, but if you need to, your doc can order it and four comapnies do this: entrogen, myriad, labcorp, and molecular diagnostics laboratories are the current ones.. Good luck to you.. ...Read more
Not sure: I am not sure about your question. I think that you are asking how long it stays in the system after 6 months of use. A typical schedule in 2 weeks on and 1 week off. The drug is quickly eliminated from the body. Kidney disease can affect the elimination. Side effects in the skin of hands and feet can take a few weeks to heal after the drug is stopped. If not helpful clarify the question please. ...Read more
Capecitabine: It may cause fatigue/weakness, nausea, vomiting, change in taste, supression to blood counts-anemia, low white blood cells, low platelet, rash/dryness/peeling skin of plams and soles, oral sore, infection, etc. Discuss further with your oncologist. Read more here http://www.Nlm.Nih.Gov/medlineplus/druginfo/meds/a699003.Html. ...Read more
Probably not: Occasionally, the cutaneous reaction may be severe. I suppose, in that situation, fingerprints may be lost temporarily. ...Read more
Variable: Xeloda (capecitabine) can cause varied side effects. Majority of patients experience skin toxicity in the form of dry skin which tends to become cracked and painful (it is called Hand foot syndrome because it is most marked on the palms and soles) . Some patients develop painful sores in the mouth(mucositis). Diarrhea is another common side effect. Some patients are genetically prone to very severe reactions. ...Read more
IT VARIES: Xeloda (capecitabine) is usually dosed at 825 - 1250 mg/m2 twice daily x 14 days depending on regimen used. It can be given alone, with radiation or with other chemotherapy drugs. To calculate dose we use Body Surface Area (BSA) x mg to get actual dose. I assume you are saying 3300 mg total daily dose. For example: 1800 mg in am + 1500 mg in pm - sounds right. Talk to your Oncologist too. ...Read more