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Cancer Odds Grandparents Colon
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
Grandfather had colon cancer at 87, uncle had noncancerous polyps at 48. Mother has no polyps. Likely a colon cancer gene?
Genetic mutations: HNPCC or hereditary nonpolyposis colorectal cancer is an autosomal dominant genetic condition that has a high risk of colon cancer The disease first described by Lynch and is associated with other cancers including endometrial ovary and stomach. The increased risk is due to inherited mutations that impair DNA mismatch repair. .Individuals with HNPCC have an 80% lifetime risk for colon ca. ...Read more
Yes and no: If you a have a true familial form (generally this means multiple 1 st degree relatives have it. Usually happens at an earlier age) then yes the course of disease is similiar. If by familial you mean 1 relative had it, then no it is variable and progress differently. ...Read more
In the US: The chances of getting any cancer, according to statistics of the american cancer society, is 45% in a lifetime for males & 38% in a lifetime for females in the us. You are not destined to get cancer because it runs in your parents, but get regular screening physical exams yearly, mammograms after age 40 females, colonoscooy after age 50. Eat healthy, don't smoke, exercise, maintain healthy weight. ...Read more
For the most part.: Early detection via colonosocpy, not ignoring symptoms such as bleeding, change in bowels, anemia, unintentional weight loss, and not assuming all rectal bleeding is from hemorrhoids are some ways to reduce your chances and maybe prevent colon cancer from developing. ...Read moreSee 1 more doctor answer
Genes: Most colon cancers are not inherited. However, there is a subset which is associated with inherited genetic abnormalities such as hereditary polyposis a this hereditary non polyposis gene (hnpp). There are also syndromes that make you susceptible to a variety of different cancers including colon cancer such as lynch syndrome. ...Read moreSee 2 more doctor answers
Not directly usually: There is debate about how closely these 2 cancers are related. Both have hereditary natures and are more common generally in obese patients. Both often begin with more benign precursor lesions like dcis for breast cancer and benign polyps for colon cancer. Both are very common but there is little evidence that having either predisposes to having the other. ...Read moreSee 2 more doctor answers
Low but not zero: Stage ii colon cancer means no lymph node involvement by definition, but inadequate lymph node sampling (surgical resection) may "understage" the cancer, so make sure enough ln were taken -minimum of 12! even with appropriate surgery, mets may still occur, although very unusual, so discuss with your treating docs. A pet/ct may give some reassurance so ask if this can be done. ...Read moreSee 1 more doctor answer
Can be: Most colon cancers relate more to lifestyle than inheritance but some patients do have an inherited predisposition, be it in the setting of multiple polyps (like fap or myh) or not (lynch syndrome). Families with this have early onset colon cancer and other cancers as well. Talk to your doc about this to see if you need to visit a specialist in inherited malignancies. Remember to live healthy. ...Read more
Varies: This varies dramatically depending on the stage. Small tumors confined to the kidney may be curable in 90% or more of people, whereas lymph node involvement or involvement of tissues surrounding the kidney may be curable in only a small percentage of people. ...Read more
Depends on what you: It is hard to know what you mean. If you mean hereditary, they typically are not except about 5 to 10% of the time there is cancer of the same type in one of the first degree relatives. But cancer is a common disease which will likely affect one in 3 people during a life time. ...Read moreSee 1 more doctor answer
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