Doctor insights on:
Cancer Genetic Testing
Prenatal testing for genetic problems may be done before or after conception. Testing for spina bifida or Down syndrome is done after a pregnancy is established. Besides the couples listed above, counseling and diagnosis are also recommended for mothers over the age of 35, and those who have received abnormal screening test results, such as alpha-fetoprotein (AFP). For more information about the alpha-fetoprotein test, and when and why you might have it, see alpha-fetoprotein. For those who may be at risk, genetic counseling and prenatal diagnosis are used to help ...Read more
For significant risk: It is not a routine test for everybody with breast cancer. However, if you have significant risk with more than one family member having breast cancer or ovarian cancer, at younger age especially or multiple other type of cancers in the family- a brca 1 and 2 analysis would be something that routinely be done to rule out breast-ovary hereditary syndrome. ...Read more
3K: Brca comprehensive test offered by myriad is about $3, 000. They have an additional test called bart which used to be charged separately but now is often done as one. Frankly, I don't know if that adds to the cost. These are covered by most insurances if ordered in the right setting. Others labs have developed tests (such as breastnext) for other genes but insurance coverage is not as clear cut. ...Read more
Risk for cancer: If you have a strong family history of breast or ovarian cancer (or less commonly prostate or pancreas), if you had cancer before certain age, or breast cancer with certain characteristics, you may be a candidate for brca testing. Please note that this should be done in a setting of a full risk assessment visit by a trained professional. ...Read more
Start w/affected pt: Pesonal and family risk factors assoc w/brca mutation: muliple fam members, bil breast cancer, male breast cancer, ovarian cancer, ashkenazi jewish heritage (specific founder mutations), diagnosis age <50 (dx age < 60 if er/pr/her2 - or triple negative). Both maternal and paternal history is important. ...Read more
Mom got ovarian cancer at 37. None of her other family got it or any other cancer. Should I consider genetic testing? How do I lower my risk?
No: While genetic testing has value in certain malignancies pointing out who is succeptible and requires careful evaluation such as in breast cancer and congenital polyposis as well as the Lynch Syndrome, ovarian adenoma ca has no major impact from congenital abnormalities. A periodic pelvic sonogram or digital pelvic exam yearly or bi yearly may be helpful ...Read more
I'm a 34 yr old female. My 63 y/o mother has colon cancer. Should I seek genetic testing? What are the pros/cons re: the genetic testing for me?
Knowledge is Power: The brca test is a simple (tho, very expensive) blood test to determine if one carries the risk of developing the hereditary form of breast (& ovarian) cancer. Affected people have a 50%chance of passing this on to their children. If the test is (-), this can be very reassuring; if (+), one may choose to be proactive and undergo prophylactic (preventive) mastectomies and oophorectomies. ...Read more
I had a PE at 29. It was idiopathic. No risk factors. Had genetic testing no problems. Could it be cancer? I have no symptoms.
Should I go for genetic testing to check for cancer vulnerability? Is it covered by ghi? Where would I get tested? How is it done? Any pros or cons
If indicated: Genetic test for what cancer? First criteria a group of family members have to suffer example breast cancer. Fear is not enough, must under go genetic counceling, if positive prepared to face psychological trauma. For breast and ovary brca mutation studies are available, and not for mass screening, most of insurances may not cover this expensive tests as routine test ...Read more
Very if BRCA mutated: The genes brca1 and brca2 cause breast-ovarian cancer, suspected when women have onset of breast cancer before menopause or when there are several cases of breast/ovarian cancer in a family. Women with a brca mutation have as much as a 50% lifetime risk for ovarian cancer (85% for breast) and often choose prophylactic oophorectomy after positive brca testing since there is no good clinical screen. ...Read more
Rogers AR genetic: Most of my patients that are from that area will go to Highlands oncology. There are many oncologists in their office and I'm sure one of them has a great interest in genetic testing. Testing can be a can of worms. Talk to the doctor first about the pros and cons and most importantly what would be done differently if positive. ...Read more
If I have polyps in my colon, should I have genetic testing to see if I will likely have colon cancer?
Maybe, maybe not: Depends on family history of colon polyps, ca, other cancers, e.g. Ovarian, types of kidney ca, , age of affected relatives, your age, number of polyps, types of polyp. Most cases of colon polyps and colon cancer are sporadic (not hereditary). Discuss with your gastroenterologist and primary doc. ...Read more
How do you get genetic testing for cancer? Every family member older then me ie parents aunts and uncles have all died with cancer and now younger bro
Its more complicated: Currently, more than 1% of all human genes are implicated via mutation in cancer.Many people think that the risk of Ca is always passed on through families as a single "cancer gene".However, like other complex diseases, changes in many genes that each play a role in the development of cancer are much more likely to be the cause of familial cancer than a change in a single gene. So, see a geneticist ...Read more
Do you recommend genetic testing such as is offered by personalized genomics companies? Prostate cancer seems to run in our family
Screening: If you are healthy and have a family member with prostate ca you should consider screening at age 40. ...Read more
Depends: If you have a valid reason to be tested-first degree family members, breast cancer under age of 50, others in family with brca positive test (to name a few)-then it should be covered by your insurance carrier. Depending on your insurance plan and deductible, there may not be any out of pocket cost. ...Read more
My aunt (dad's sis) and grt-grandma (pat grandma's mom) both died of ovarian cancer. How likely is it hereditary? Would genetic testing be good idea?
Possibly: Two family members with ovarian cancer is not that common. There are a few inherited conditions that increase ovarian cancer risk. I would suggest that you gather all family info you can get hold of (all family with or without cancer) and visit with your gyn or family doc. They will decide of you need to be seen by a specialist in hereditary cancer. ...Read more
Maybe: If in doubt go to a genetics counselor - most cancer centers have one. The consultation is not expensive, but the test itself is. They will ask about your age, the exact numbers of family members affected, their age at diagnosis, whether one or both breasts, their relationship to you (mother, sister, or daughter increase your personal risk), other cancers in the family. Then they can advise you. ...Read more
What can I do if my mom was diagnosed with breast cancer. Should I think about getting genetic testing?
It depends: Most breast cancers are not genetically passed down to daughters but some are. You need to learn more about genetic breast cancer. Unless your mother has other blood relatives with breast or ovarian cancer, you do not need genetic testing unless your mother had breast cancer before the age of 50 years. However you should take precautions for early detection and get clinical breast examination regu. ...Read more
Can you tell me if given the oppurtunity to get genetic testing for the breast cancer gene should I do it?
Informed decision: No one can tell you if genetic testing is right for you; it is your decision. See a genetic counselor or geneticist to go over all of the pros and cons of genetic testing before you make your decision. The goal of genetic counseling is to help you have all the information you need to make an informed, personal decision. ...Read more
My mom had two types of very aggressive breast cancer. I'm almost 30, would it be wise to ask for genetic testing?
Yes: It depends on other factors, like your mom's age at diagnosis. If she was under 50, and particularly if you have other first-degree relatives with breast cancer (sister, daughter) or ovarian cancer, you may be at risk for carrying the brca gene. Ask for genetic counseling instead of genetic testing, as the type of test you need depends on a more extensive review of your history. Good luck! ...Read more
How many relatives need to have had breastcancer before you should get genetic testing for the BRCA genes? My mother contracted breast cancer, I am 40
Most breast cancer is NOT due to an inherited risk, but rather occurs by chance. Family history that suggests an inherited risk, such as changes in the BRCA1 gene or BRCA2 gene, include multiple relatives with cancer over more than one generation and younger ages of onset.
If you are concerned about an inherited risk, see a geneticist who can assess your family history. ...Read more
Is there a genetic test that shows who is more at risk for certain cancers, even without family history of them?
Is there an available genetic test for a lot of different cancers now? How reliable are the results in making predictions?
What doctor should I go to, to take a genetic test to see if I may have cancer-causing genes in my genes?
A geneticist will help you go through your family tree assuming you know some details about the specific kinds of genetic disorders your other family members have, or you have.
A medical oncologist is trained to perform a comprehensive evaluation to see if you have risk factors for having a particular genetic cancer syndrome, such as those that are related to breast and colorectal cancer. ...Read more
No: Many factors influence how long someone with breast cancer will survive, but there is no genetic test that can predict this. ...Read more
Has anyone had or heard of a genetic test you can have to see if you are at risk for breast cancer?
BrCA 1 and 2: We can test forcertaintypes of hereditary breast cancer caused by the brca genes 1 and 2. There is also a test for lynch syndrome that causes increased risk of polyposis colorectal cancer, breast, and uterine cancer. Tests are available for li fraumeni which is very rare. We think that more (and cheaper) genetic testing will be available in the next several years. ...Read more
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more