Doctor insights on:
Cancer Drug Medication
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
Multidisciplinary: Developing a cancer drug is an involved process that need contributions of chemists, biochemists, molecular biologists, doctors, pharmacologists, and more. Nanotechnology has not played a major role, yet. ...Read more
Extensive testing: After going through pre-clinical testing in cell culture lines and animal models, a cancer drug is tested in humans. A phase I trial looks for safety information regarding the maximum tolerated dose of a drug. A phase ii trial looks for initial efficacy possibilities in a particular cancer population. A phase iii trial compares the new treatment against the current standard option. ...Read more
There are a few drugs that use this idea such as abraxane. There are mulle possibilities. Currently an chemotherapy is attached to a carrier molecule and attached to an antibody for breast cancer.
Delivery might be less important than targeting weakness in cancer cells more specifically. ...Read more
Approx how many years will it take for a experimental cancer drug (ima901) beginning from phase-3 to clinically available in market for patients use?
Cannot predict.: Ima901 is an immune therapy (cancer vaccine) for renal cell carcinoma of the kidney. It is currently under investigation in multi center phase 3 trials in europe and the U.S. Our center is not part of the trial, but information at clinicaltrials. Gov shows that phase 3 is currently accruing patients. They estimate data in 2014. It takes a mean of 8 years from the start of phase I trials to market. ...Read more
Several: Herceptin (trastuzumab) is remarkably well tolerated. The most common side effect is a decline in the pumping ability of the heart (called the left ventricular ejection fraction), possibly leading to congestive heart failure. Thus, people getting Herceptin (trastuzumab) should have an echocardiogram done before, and about every 3 months while on herceptin (trastuzumab). Most of the time, the heart recovers after the Herceptin (trastuzumab) is stopped. ...Read more
Medical ethics: With out clinical trails best drugs can not be assessed for effectiveness, it is not with out risk as risks to the human body are known yet, also will loose critical time, . On moral and ethical ground one can't give advise, it is up to you and you decide. Good luck. ...Read more
While it one of: The oldest anti-cancers, it has no marrow suppressive effecs. As a vinca alkaloid, it interferes with the mitotic spindle formation necessary for actively dividing cells. It is used in many pediatric tumors as a cornerstone drug. Leukemias and lymphomas. It does not work very well in most adult solid tumors. ...Read more
It is Jakafi (ruxolitinib): It is a new drug which has been approved recently and is useful to treat a blood disorder called Myelofibrosis where the body doe snot produce enough blood. So this drug has offered some relief (we had no other drug to treat this type of Cancer before Jakafi (ruxolitinib). ...Read more
Afinitor/everolimus: It is an M-TOR inhibitor, indicated as treatment for kidney cancer, Pancreatic neuroendocrine tumor, certain cases in breast cancer along with aromasin (exemestane) to overcome resistancy. Open this link: http://www. Cancer. Org/treatment/treatmentsandsideeffects/guidetocancerdrugs/everolimus ...Read more
Targeted cancer drug: Pertuzumab is a drug that targets cancer cells which carry a certain protein on their surface called her2. It has been approved for treatment of metastatic breast cancer that is her2 overexpressing. You can think of her2 like a light switch that makes cancer cells grow. Pertuzumab blocks the switch from being turned on from the outside. Herceptin (trastuzumab) is a similar drug. ...Read more
Inhibits cell signal: Afinitor (everolimus) or Evrolimus works by affecting a tumor cells function called a signal transduction thru inhibition. While many chemo drugs effect DNA metabolosm, signal transduction inhibitors stop some of the signals within cells that make them grow and divide. Everolimus stops a particular protein called mTOR from working properly. MTOR controls other proteins that trigger cancer cells to grow. ...Read more
Various: As stated the typical side effects are inflammation of the bladder which usually resolves. Some patients becoem intolerant and cannot receive the treatment. If BCG is absorbed into the bloodstream it can result in massive infection and (rarely) death. Bcg should never be given if there is obvious blood in the urine. Also the pt shouldvoid into the same toilet for 24 hours after BCG and add bleach. ...Read more
Clinicaltrials. Gov is a comprehensive database of clinical trials in the United States and around the world.
You may also find
www. Researchmatch. Org
useful, as it is geared specifically to patients.
(note: researchmatch is an nih-funded project I learned about at vumc through the work of paul harris - I have no conflict of interest). ...Read more
Trade name: Trade name drugs are sold under a monopoly so the drug companies can recoup their investment in researching and developing a drug. Generic drugs are sold by competing companies once the original patent expires. The competition drives down prices and limits profits. ...Read more
Years: That is billion dollar question and also equally that expensive to release the drug. Safety and effectiveness is tested in phase iii for fda approval to go for phase IV to public rx may take may take long time, some times years and some times never drug disappears. Public safety is essential, look what happened to thalidamide, a tragedy. ...Read more
My dr. Wants to try me on the cancer drug tamoxifen for infertility. I have never had cancer. Is this healthy?
Benefit/risk: Tamoxifen is a SEAM (selective estrogen receptor modulator). It inhibits estrogen receptor pathway in breast, but stimulates it in ovary and uterus. It may increase fertility for a time, but reduce later due to constant stimulating. Its stimulating effect can also increase risk of uterine cancer. Other side effects from tamoxifen include thrombosis, stroke, etc, esp at long-term use. ...Read more
What do you suggest if my dr. Wants to try me on the cancer drug tamoxifen for infertility. I have never had cancer. Is this ok?
Yes: Tamoxifen is used to prevent breast cancer where it suppresses estrogen binding, it can act as an estrogenic stimulus on ovarian tissue initiating ovulation induction by a mechanism similar to clomiphene citrate. This drug Clomid is able to bind to estrogen receptors in the hypothalamus. Preventing the brain from seeing the negative signal from estrogen This stimulates production of FSH. ...Read more
Salvage Rx: For her2-positive breast cancer that's relapsed. Http://www. Medscape. Com/viewarticle/811845. ...Read more
How can I buy cancer drug xalcori in us using prescription from germany? Patient is in germany and can’t come to us. I can make verified translation.
Ask the manufacturer:
You can ask the manufacturing company - pfizer- about how to export xalkori (crizotinib) to germany. Here is the link - http://www. Pfizer. Com/contact/contact_us_support. Jsp
good luck. ...Read more
Need more info:
Which drugs is this some one on? It would be prudent to talk to the doctor who prescribed the medications.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex, if you have sex. ...Read more
Myocyte damage: Adriamycin (doxorubicin) originally derived from bacteria, an antibiotic used in cancer treatment can damage cardiac myocytes by interfering oxygen transport inside the cell, (by decreasing in mitochondrial oxidative phasphorylation), by simple words choking heart muscle cells. It is dose related.. ...Read more
What to do if I use fluorouracil cream (cancer drug) to treat a rash. Will I get cancer because of that?
No: Efudex (fluorouracil) cream is a cutaneous method of applying 5 FU (a chemotherapeutic agent) to cutaneous basal cell and some cutaneous squamous cell Ca's. It is applied daily x 10 followed by an application of A&D ointment to the same area that has become inflamed. In many cases the skin tumor will completely regress. Sometimes a repeat treatment needed. Should not be used for rashes. Does not cause Ca. ...Read more
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