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Doctor insights on: Cancer Antigen Ca 125

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Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Likely, no: CA 125 is not recommended as a screening tool for ovarian cancer when used in risk-based stratification. Meaning, assuming that your mom or sister didn't get diagnosed with ovarian cancer. Normal for women with endometriosis to have elevated CA-125. It sounds like your doctor has done Ultrasound to evaluate ovaries as well. Your MD knows your history and risk, likely this CA-125 level is normal ...Read more

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Dr. Barry Rosen
4,214 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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What happens if ca 125 is normal .am I free from cancer?

I wish: CA 125 is elevated in some, but by no means all, ovarian cancers, and in enough healthy people to make it not very helpful as a screening test. It's also normal in the vast majority of people with cancer elsewhere. ...Read more

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If ca 125 is normal, am I free from cancer or is the cancer hiding?

Neither: If you had an elevated ca-125 prior to surgery for ovarian cancer and the level is down to a normal person's, then we can hope you have a cure, and should the level rise again it will be early warning. By itself, a normal ca-125 rules out nothing. I'm glad you're taking a proactive approach to your health. Good luck. ...Read more

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If your ca-125 stays over 200 does that mean there is still cancer in your body?

Not necessarily.: The ca125 tumor marker is a notoriously non-specific indicator of disease (i.e. It can be elevated for reasons other than cancer). It is frequently most useful for tracking the progression or regression of a disease over time and less useful as a standalone diagnostic test. ...Read more

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Why wouldn't a ca 125 be zero when there is no cancer? Where is the value above 0 coming from?

Basic lab medicine: A small amount of the substance, which is coded by the normal genome, is ordinarily present in the bloodstream. Immunoassays also detect antigens similar to ca125 as weak signals, and a cutoff is established below which a reading is not suspicious for cancer. These facts have a lot to do with why these markers aren't all that helpful in searching for cancers in folks without any signs. ...Read more

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Does an elevated ca 125 level always indicate that ovarian cancer is present?

Does an elevated ca 125 level always indicate that ovarian cancer is present?

No: Ca-125 may also be elevated in other cancers (i.e. Endometrial, fallopian tube, lung, breast and gastrointestinal cancers.) it can also be elevated with endometriosis or any inflammatory condition in the abdominal area. ...Read more

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Where do I get a ca-125 blood test if I have no insurance but worry about cancer?

Where do I get a ca-125 blood test if I have no insurance but worry about cancer?

Save your $$: This blood test is useful only in certain situations and is not accurate if you are trying to make a new cancer diagnosis. It can be high even if you don't have cancer, and it can be normal in some situations when you do have cancer. My advice is to save your money, and visit your doctor if you have a specific concern. ...Read more

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Not long ago found out that many times blood test called 'ca125" can tell if you have cancer.is it true?

Not long ago found out that many times blood test called 'ca125" can tell if you have cancer.is it true?

No: Ca 125 is a tumor marker which is frequently associated with ovarian cancer. The " Ca" refers to carbohydrate antigen which has little to do with cancer except when it is known that ovarian cancer is present. At that time the test can be used, for "monitoring" the response to treatment, but not for making the diagnosis. One of the frequent causes of an elevated Ca125 is alcoholic cirrhosis. ...Read more

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I had a ca 125 test done. Came back at 66 (no history of cancer). Ultrasound normal. Dr. Says no further evaluation needed. Is this true? I am 45

Agree: You should have never had that test done (ca-125) without a diagnosis of ovarian cancer. It is a nonspecific test. But i agree, no further testing necessary. Routine follow up with your pcp and gynecologist. Hope this helps. ...Read more

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I had a ca 125 test done(no previous history of cancer)that came back as a 66. Ultrasound came back normal. Dr. Said no further evaluation is needed. True?

I had a ca 125 test done(no previous history of cancer)that came back as a 66. Ultrasound came back normal. Dr. Said no further evaluation is needed. True?

A CA 125: Test should never be ordered out of the blue, especially in a young woman with no cancer history. It increases the cost of health care, leads to unnecessary testing and worry. Despite good intent, this is bad practice. ...Read more

Dr. Milton Alvis Jr
125 doctors shared insights

Ca125 (Definition)

Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more


Antigen (Definition)

Antigens are chemicals which upon exposure to the surface or inside of the body, will cause a reaction term allergic. Many substances will do this and allergic response is the basis for immunological protection for ...Read more