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Doctor insights on: Can Zoloft Get You High

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Dr. Heidi Fowler
1,087 doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


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Breastfeeding on 50mg Zoloft (sertraline). Need to go up to 75 but worried about baby getting more medication. Is 75 a high dose while nursing? Will she get more?

Breastfeeding on 50mg Zoloft (sertraline). Need to go up to 75 but worried about baby getting more medication. Is 75 a high dose while nursing? Will she get more?

Not really : The AAP released an article on 8/23/2013 advising that most medications are safe for breastfeeding mothers, although antidepressants were cited as ones with potential problems, yet it wasn't recommended to stop it, the NIH Toxnet and Lactmed databases didn't recommend stopping it either, check them for more information. You want to tell your child 's pediatrician about it too, enjoy your baby ...Read more

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Can kids get hi off their zoloft (sertraline)?

Can kids get hi off their zoloft (sertraline)?

NO: Any side effect is possible in a given patient. Sertraline (zoloft) is usually a calming agent. ...Read more

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How long can Zoloft (sertraline) take to get out of your system?

How long can Zoloft (sertraline) take to get out of your system?

Male or woman: Depends. It's half-life is long. Average is considered about 24 hours just to get half of it out of your body. It may be 1.5 times longer in women. And, remember, the next 24 hours just gets half of the remaining half out of you. ...Read more

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Can Zoloft (sertraline) cause someone to get angry or in a fit of rage often? I've read that it can and its somewhat common, is that true?

Can Zoloft (sertraline) cause someone to get angry or in a fit of rage often? I've read that it can and its somewhat common, is that true?

It is reported: Any of the drugs known as ssri's can and have been reported to cause mood swings such as drowsiness ; lethargy to anger and rage or even suicide. Their effectiveness according to long term population studies has been brought into question as of late and some suggest that as a class of drug it is being overprescribed to the general population. ...Read more

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If im taking zoloft 150mg and abilify (aripiprazole) 2mg is that correct or zoloft too high?

If im taking zoloft 150mg and abilify (aripiprazole) 2mg is that correct or zoloft too high?

Zoloft (sertraline) can be higher: These are appropriate doses of both zoloft and abilify (aripiprazole) and it is not unusual to see higher doses of both ...Read more

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How common is it to get side effects from taking zoloft (sertraline)?

How common is it to get side effects from taking zoloft (sertraline)?

Common: Side effects are common early on & most often diminish over time (a week or 2). If they are serious, fail to diminish, or are intolerable, then contact your prescriber immediately for instructions & consideration of alternative medication.
See comment below. ...Read more

Dr. Alan Ali Dr. Ali
2 doctors agreed:
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Any advice on how I get better deal with Zoloft (sertraline) withdrawals?

Dr. Alan Ali Dr. Ali
2 doctors agreed:

Zoloft (sertraline): Depends on what dosage u r currently on, & reasons zoloft (sertraline) was prescribed. Gradual tapering over several weeks is duable, with guidance of your prescribing doctor. ...Read more

Dr. Alan Ali Dr. Ali
1 doctor agreed:
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How best to get out of zoloft (sertraline)? My sister is always lethargic.

Dr. Alan Ali Dr. Ali
1 doctor agreed:
How best to get out of zoloft (sertraline)? My sister is always lethargic.

Zoloft (sertraline): Best to consult the prescribing doctor who knows the case & can give best advise. ...Read more

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How can I get the comparison of chemical structures for Zoloft (sertraline) and Valium?

PDR: PDR= Physicians Desk Reference has photos of the chemical structure. It is very reliable and updates yearly. ...Read more

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Can I take 25mg of Zoloft (sertraline) twice daily? When I take 50mg at once I get horrible side effects

Yes: Dividing the dose to Zoloft (sertraline) 25 mg twice daily is fine. Try to take consistently at the same time each day. Be sure to discuss with prescribing doctor. ...Read more

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Been taken Zoloft (sertraline) 50mg for 4+ months but get mad and start crying once in a while. Do I need an increase in dose?

Been taken Zoloft (sertraline) 50mg for 4+ months but get mad and start crying once in a while.  Do I need an increase in dose?

Zoloft (sertraline) and emotions: It depends on if your symptoms are generally "improved" from before going on the Zoloft (sertraline). You can still have "bad" days.but hopefully you are more level on the Zoloft (sertraline) overall. The dose can be adjusted if no improvement or another med used! ...Read more

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My pdoc increased my Zoloft (sertraline) from 50mg daily to 100. Will I get side effects and how long to feel the effects of it working?

Zoloft (sertraline): Not everyone gets side effects with zoloft (sertraline), (sertraline) even when the dose it raised. You are still well within a normal dose range. Many people need 150mg zoloft (sertraline) daily. Generally zoloft (sertraline) requires at least 4-6 weeks for effectiveness, although you may experience this sooner. ...Read more

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I have been on Zoloft (sertraline) 12.5mg for 3 weeks with the most horrible side effects. If no longer want to take this medicine. How do I get off of it?

I have been on Zoloft (sertraline) 12.5mg for 3 weeks with the most horrible side effects. If no longer want to take this medicine. How do I get off of it?

Talk w/doctor: First, I suggest talking with your doctor about your decision. The zoloft (sertraline) must have been prescribed because of some symptoms you were having, and these may still need treatment even if zoloft (sertraline) is not the best option for you. You also haven't mentioned what "horrible side effects" you're experiencing -- but I'm sure your doctor would want to know so that something more helpful can be given. ...Read more

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I would like to get off zoloft (sertraline). I am down to 25mg but do not want to go to 12.5mg immediately. How to titrate down slower? Say 5mg per titration?

You can: You can titrate down Zoloft (sertraline) as tolerated. If you are sensitive then do it in gradual dose reduction each week. It could be by mg or 12.5 mg reduction. However, I hope that you are doing this in consultation with your doctor because the symptoms that Zoloft (sertraline) was taking care of can recur after a few weeks too few months. Be on the lookout for that. ...Read more

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Iv been taking Zoloft (sertraline) for 2 months, my anxiety is under control, but IV noticed that I don't get as excited anymore about happy stuff. Is this normal?

Yes: Antidepressants like zoloft (sertraline) do have side effects. Some patients feel that their mood sort of flattens out and they do not get overly excited or angry in appropriate situations. Usually as the depression lifts with appropriate dose, then the mood improves and energy & motivation is restored. Continue taking your medicine and discuss this issue with your physician on next appointment. ...Read more

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Zoloft (sertraline) has helped my anxiety but now I feel in between emotions. I don't get overly excited like I use to and I don't get down as much. Is this normal?

Paradox with Zoloft (sertraline): It is possible to have a paradoxical reaction to an antidepressant such as zoloft (sertraline). These reactions: increasing anxiety or feeling no emotions means it is time to try a new medication. This is not dangerous but it is common and needs to be addressed by the professional who you have been working wth. ...Read more

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Does high dose of Zoloft (sertraline) cause hypertension?

Does high dose of Zoloft (sertraline) cause hypertension?

No HTN with Zoloft (sertraline): Zoloft (sertraline) does not cause hypertension, even at high doses. Best wishes. ...Read more

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I mixed Zoloft (sertraline) with methamphetamines. I'm Hallucinating. Too high. Should i be concerned?

ER: Get to an emergency room right this minute! Shut the computer off, and go to your local emergency room right now. Dial 911, because likely you are not safe to drive. Or have a friend drive you there. Again do it right this minute! ...Read more

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Chol 205 hdl 57 ldl 81 trig 337. Chol was <180 before. Exercise & eat well, but gaining weight. Take Zoloft last 2yr. Are high trigs a concern? Chol?

Chol 205 hdl 57 ldl 81 trig 337.  Chol was <180 before. Exercise & eat well, but gaining weight. Take Zoloft last 2yr. Are high trigs a concern? Chol?

Lipids?: You did not give you smoking history or your family Hx of early heart disease. High tris are a concern and often related to alcohol intake. Discuss with your team. ...Read more

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Do u consider 25mg ritalin ir 3x a day with 50 mg Zoloft (sertraline) 2x a day (so 100mg Zoloft (sertraline) + 75mg ritalin) safe? Or the risk of serotinin syndrome is high?

Do u consider 25mg ritalin ir 3x a day with 50 mg Zoloft (sertraline) 2x a day (so 100mg Zoloft (sertraline) + 75mg ritalin) safe? Or the risk of serotinin syndrome is high?

It is safe: The risk of serotonin syndrome is low. On jan, 10, 2014: 9, 189 people reported to have side effects when taking ritalin. Among them, 19 people (0.21%) have serotonin syndrome.
Only 8 were on zoloft (sertraline). Therefore, since zoloft (sertraline) and Ritalin have been used together for around 20 years, only 8 cases of serotonin syndrome have been reported with this combination.
www.ehealthme.com/ds/ritalin/serotonin+ syndrome. Best wishes. ...Read more

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If I get put on ritalin and Zoloft (sertraline) are these for life?

Meds for life: It depends if depression is recurring and affecting the life you may have to stay on meds longer with combination of therapy and meds it can be reduced and fewer doses needed. Goal is you build up skills to deal with the stress your response is not affecting your life too much and can handle it a healthy positive way. ...Read more

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Will I get any withdrawal symptoms from stopping Zoloft (sertraline) after 3 days?

Doubtful: I have not seen patients show discontinuation symptoms after such a short period on zoloft (sertraline) but it is important to talk with your provider before starting or stopping medications. ...Read more

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Can see if I could get off of Zoloft, (sertraline) have me get a prescription of Abiify instead huh? Just wondering!

Depression: Lindsey, Abilify (aripiprazole) is an atypical antipsychotic medication that is used at low doses to usually supplement the SSRI's like Zoloft. So we usually add it to Zoloft to help with depression that is still not better with Zoloft. I recommend that you do in and discuss with your doctor your concerns about Zoloft, such as side effects, not working, etc. and see what you both would like to do. ...Read more

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About to increase my Zoloft (sertraline) dose from 50mg to 75mg. Will the sexual side effects get worse or stay the same usually?

Not much difference: Sexual side effects on SSRIs are generally dose related, but going from 50-75mg of Zoloft (sertraline) is not big enough to make much difference. If depression/anxiety improve sexual function might improve esp interest. Young men often find it helps sexual function as it prevents premature ejaculation. When I have a young man be very sensitive to sexual side effects of SSRIs, I suspect bipolar disorder. ...Read more

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I take Zoloft (sertraline) and Fluanxol from a week. 100 mg Zoloft (sertraline) and 1 mg Fluanxol and I get convulsions. Is this sth to worry about?

I take Zoloft (sertraline) and Fluanxol from a week. 100 mg Zoloft (sertraline) and 1 mg Fluanxol and I get convulsions. Is this sth to worry about?

Contact doctor ASAP: Zoloft, (sertraline) an antidepressant, and Fluanxol, an antipsychotic, can both potentially lower the seizure threshold in susceptible patients. It appears you are also on Tobramycin, an antibiotic. Altogether, the combination may make you more prone to untoward side effects. Recommend you notify your doctor at once. All the best. ...Read more

Dr. Heidi Fowler
1,042 doctors shared insights

Zoloft (Definition)

Zoloft is a serotonin reuptake blocker which is a kind of ...Read more