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Doctor insights on: Can Zoloft Cause Headaches

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Dr. Bennett Machanic
4,158 doctors shared insights

Headache (Definition)

The medical term is cephalalgia. It is a feeling of pain that can occur on either both sides or just one side of the head or neck. Headaches can be sharp, dull, or throbbing, and can radiate to different areas of the head. They typically last less than an hour but can ...Read more


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When i haven't taken my Zoloft (sertraline) in 2 + days (rarely happens that i skip) why does it cause me headaches?

When i haven't taken my Zoloft (sertraline) in 2 + days (rarely happens that i skip) why does it cause me headaches?

Withdrawal symptom: When you miss your zoloft (sertraline) dose, you could be experiencing some withdrawal (or what the drug companies call "discontinuation") effects -- which can include headache. I'm glad you rarely skip your doses for 2+ days. ...Read more

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What pain relievers can be taken with Zoloft (sertraline) for a headache?

What pain relievers can be taken with Zoloft (sertraline) for a headache?

Most: There is no drug interaction with NSAIDs or opiates. However if a tricyclic antidepressant is used for pain control , it may affect the effect of Zoloft (sertraline). However there may be an additive sedating effect from opiates. ...Read more

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I started 50 mg Zoloft (sertraline) five days ago i have headaches and decreased in appetite increased in anxiety should i stop Zoloft (sertraline) ?

I started  50 mg Zoloft (sertraline) five days ago  i have  headaches and  decreased in appetite increased in anxiety should i stop Zoloft (sertraline) ?

Talk to your dr.: Don't do anything without talking to your dr. It can be hard starting a new medication but you need to be able to understand the side effects and the goal of the treatment. It sounds like you need help with this transition. Are you in therapy? Therapy can be very helpful with the problems that you describe. Good luck and best wishes. ...Read more

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How much time does nausea and headaches take to go away after stopping zoloft (sertraline)?

How much time does nausea and headaches take to go away after stopping zoloft (sertraline)?

Several week. : Zoloft (sertraline) takes about four to five weeks to get entirely out of your system Make sure you taper the drug not stop it altogether abruptly. If so the symptoms may get actually get worse for a while. The complaints should resolve once the meds are out of your system. if it longer than that you need medical consultation. ...Read more

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I've had a headache and dizziness for almost 3 weeks now. Been on Zoloft (sertraline) for over a year. Could it be causing my headache?

I've had a headache and dizziness for almost 3 weeks now.  Been on Zoloft (sertraline) for over a year.  Could it be causing my headache?

Must see your Dr now: Zoloft (sertraline) would be unlikely to be the cause of headaches and dizziness if you've taken it for the past year without a problem. However, Zoloft (sertraline) can uncommonly cause a mineral imbalance causing your serum sodium to fall too low (hyponatremia). This can cause similar symptoms. Anyone with a headache lasting more than several days should consult with a physician. A headache lasting 3 wks >>urgent visit ...Read more

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I'm rxd zoloft (sertraline). I have headaches 6-7 days/week. When i take it as rxd, i get very severe headaches. Isn't there similar meds that won't do this? Ouch.

Serotonin: A treatment for migraine is to reduce serotonin levels; a treatment for depression is to raise them. In some people treatment of one produces symptoms of the other. Check with your psychiatrist about the use of a non ssri antidepressant. ...Read more

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Anxiety bad switching 100 to 50mg of zoloft (sertraline). Amitriptiline 10mg substitute b/ headaches at 100mg of zoloft (sertraline). What is best balance = to 100 zoloft (sertraline). ?

Anxiety bad switching 100 to 50mg of zoloft (sertraline). Amitriptiline 10mg substitute b/ headaches at 100mg of zoloft (sertraline). What is best balance = to 100 zoloft (sertraline). ?

Be careful: This is a mix of a tricyclic antidepressant and a selective serotonin reputable inhibitor. The most important principle is very cautious introduction and very slow escalation in dose. The potential for qtc prolongation is elevated in this scenario and an ekg might be a precaution in dose adjustments. I would be surprised if you need more than 10 mg, 20 mg or 25 mg of amitriptyline. Talk to your md. ...Read more

Dr. Donald Jacobson
1,039 doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


Dr. Alan Ali
991 doctors shared insights

Zoloft (Definition)

Zoloft is a serotonin reuptake blocker which is a kind of ...Read more