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Doctor insights on: Can You Take Mucinex With An Antihistamine

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Should you take Mucinex (guaifenesin) and an antihistamine together?

Should you take Mucinex (guaifenesin) and an antihistamine together?

No harm: There is no contraindication in taking an antihistamine together with a mucolytic (breaks up mucus) like mucinex (guaifenesin). However, the most effective treatment for nasal allergies is nsasl cortisone type sprays. ...Read more

Dr. Paul Carter
601 doctors shared insights

Antihistamine (Definition)

Sedating and non-sedating antihistamines prevent and treat allergic reactions, and are ...Read more


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I am treating acute bronchitis with mucinex (guaifenesin). Today my nose is very itchy but i read I should avoid antihistamines due to bronchitis. Any suggestions?

I am treating acute bronchitis with mucinex (guaifenesin). Today my nose is very itchy but i read I should avoid antihistamines due to bronchitis.  Any suggestions?

Need antibiotics to: Acute bronchitis does not show up on x-ray. I put my patients on antibiotics and sometimes IV steriods depending if I am going to admit them or not and bronchodilators. Never heard that antihistamines should not be used in bronchitis. If your nose is very itchy, could be allergens in which case, you may benefit from nasonex (mometasone). Mucinex will help loosen the phlegm. ...Read more

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Can i take a benadryl (diphenhydramine) & Mucinex night together?

Can  i take a  benadryl (diphenhydramine) & Mucinex night together?

Yes: Benadryl (diphenhydramine) will help you sleep and help with excess mucus production. Mucinex (guaifenesin) is called an expectorant as it helps thin and loosen mucus to make your cough more effective at clearing the mucus from your lungs. There should be no problem taking these two medications together. ...Read more

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I just took a mucinex. Will i be okay if i take Benadryl (diphenhydramine) as well?

I just took a mucinex. Will i be okay if i take Benadryl (diphenhydramine) as well?

Not a good idea: You have to know Mucinex help thin the phlegm and Benadryl (diphenhydramine) has drying effect on mucous or phlegm, so you are defeating the purpose of taking musinex if you need to take antihistamine with Mucinex for allergy, i will recommend takind over the counter Claritin which may not be as drying as benadryl, (diphenhydramine) and dont forget to drink lot of fluids. ...Read more

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Can i take Mucinex dm and Benadryl (diphenhydramine) together?

Can i take Mucinex dm and Benadryl (diphenhydramine) together?

Medician Question: This combination could make you very sleepy so be careful - in some cases there could be serious consequenses. See your doctor for more definitive treatment of your cough. ...Read more

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Can I take mucinex D and benadryl (diphenhydramine)? I have taken mucinex D for a combination of a cold and allergies but just had an allergic reaction to a food.

Can I take mucinex D and benadryl (diphenhydramine)? I have taken mucinex D for a combination of a cold and allergies but just had an allergic reaction to a food.

Yes, but . . .: If any tongue or lip swelling, or difficulty breathing/swallowing, call 911 or local emergency services. Need to avoid allergen & carry EpiPen (epinephrine). www.drugs.com Interactions Checker says there's no interaction btwn Mucinex D (guaifenesin & pseudoephedrine) & Benadryl (diphenhydramine). However, only antihistamine like latter is useful for allergies. Former is combo of expectorant & decongestant. ...Read more

Mucinex (Definition)

Guaifenesin is a cough suppressant which is a kind of antihistamine type drug (common ...Read more