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Doctor insights on: Can You Still Have Rheumatoid Arthritis With A Negative Rheumatoid Factor Test

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Can you still have rheumatoid arthritis with a negative rheumatoid factor test?

Can you still have rheumatoid arthritis with a negative rheumatoid factor test?

Yes: While the vast majority of patients with RA have a positive rf, a certain percentage do not. Typically, the younger the patient, the better the chance the rf may be negative, depsite a clinical diagnosis of ra. Read more

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Dr. Thomas Namey
2,413 Doctors shared insights

Arthritis (Definition)

A condition where there is progressive degeneration of one or more joints. Symptoms may include joint pain, swelling, decreased motion, and stiffness. The two most common types of arthritis are osteoarthritis, which is associated first with articular cartilage breakdown with a component of inflammation, and rheumatoid arthritis, which is a systemic autoimmune disorder that affects joint linings first and secondarily ...Read more


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How is it possible for someone to have rheumatoid arthritis with a negative rheumatoid factor?

How is it possible for someone to have rheumatoid arthritis with a negative rheumatoid factor?

Great question!: Rheumatoid arthritis (RA) is a disease that generally causes stiffness, swelling, and pain of the small joints of the body (wrists, fingers) in a symmetric manner. For the majority of patients with RA, rheumatoid factor and anti-CCP antibodies are found in the blood. However, these tests are not required to make the diagnosis if there are other findings on exam that are consistent with RA. Read more

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I went to get tested to see if I have rheumatoid arthritis and the result came back positive. What does Rheumatoid Factor H12 mean? < 10 kU/L (range)

I went to get tested to see if I have rheumatoid arthritis and the result came back positive. What does Rheumatoid Factor H12 mean? < 10 kU/L (range)

Slight elevation: This is a slight elevation of your Rheumatoid factor WHICH IS SEEN IN A LOT OF DISORDERS BESIDES heumatoid arthritis! You should see a Rheumatologist for a more complete work-up! Hope this helps Good Luck Dr Z Read more

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My Rheumatoid Factor went from 29 to. 53. Could this be mild start to rheumatoid Arthritis, have severe painful feet red hot & swollen.

My Rheumatoid Factor went from 29 to. 53. Could this be mild start to rheumatoid Arthritis, have severe painful feet red hot & swollen.

Possibly: A CCP antibody is a much better test but your symptoms could suggest RA. See a rheumatologist to establish a diagnosis and begin treatment. Intense inflammation limited to the feet can also suggest gout. Read more

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I tested positive for the ANA screen, 1:160 titer, speckled pattern. Rheumatoid factor 21, SED rate 22. Does this indicate Rheumatoid arthritis?

I tested positive for the ANA screen, 1:160 titer, speckled pattern. Rheumatoid factor 21, SED rate 22. Does this indicate Rheumatoid arthritis?

No: The rheumatoid factor was barely above negative. It is usually greater than 150 in RA. The CCP antibody is a much more specific test. The diagnosis of RA depends on several diagnostic criteria. The rheumatoid factor is nonspecific. Read more

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My ESR is 34, rf, aso &ana tests all are negative. I have joint pain in my finger, knee & toe. Mild swelling in 3 fingers at dip joint. Can I still have rheumatoid arthritis?

My ESR is 34, rf, aso &ana tests all are negative. I have joint pain in my finger, knee & toe. Mild swelling in 3 fingers at dip joint. Can I still have rheumatoid arthritis?

Possible: It is possible to have sero- negative ra, in which the rheumatoid factor assay is negative. It is also possible that you have another autoimmune illness, there are some overlaps in these conditions and the lab work doesn't always give an exact diagnosis. You should see a rheumatologist if your joint inflammation persists. Read more

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How often should one be tested for rheumatoid arthritis after negative test, though having symptoms?

How often should one be tested for rheumatoid arthritis after negative test, though having symptoms?

Arthritis: There are negative test and there are additional tests that may be followed for a now symptomatic person with rheumatoid or infalmmatory as much as at a certain level. Talk to your doctor about this especially if you are taking medications. Read more

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Can a person have a negative RA titre have rheumatoid arthritis?

Can a person have a negative RA titre have rheumatoid arthritis?

Arthritis: There are many types of arthritis, some of which are degenerative or post-traumatic. The other general kind of arthritis is inflammatory. The classification of type requires a history, examination, diagnostic x-rays, and if indicated, blood tests. Treatment is determined by type of arthritis. Not all patients with RA have positive blood tests. Occasionally, blood tests are done a few times. Read more

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What does negative antinuclear test mean Can it rule our rheumatoid arthritis?

What does negative antinuclear test mean Can it rule our rheumatoid arthritis?

NO: Get checked for rheumatoid factor, ASLO, CBC and sed rate as well as an examination by a rheunatoligst. Read more

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I tested positive for lupus and negative for rheumatoid arthritis. How accurate are these tests?

I tested positive for lupus and negative for rheumatoid arthritis. How accurate are these tests?

Tests are accurate: If you have the right tests theses are quite accurate. You should discuss with your doctor who ordered the tests, because he knows your clinical history and will be able to explain the results to you. I can not answer without knowing the tests which were done. Read more

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Is it possible to have little to no swelling with rheumatoid arthritis? Also, can your blood test negative and then be positive later?

Is it possible to have little to no swelling with rheumatoid arthritis? Also, can your blood test negative and then be positive later?

Yes: Yes, there can be periods of increased as well as decreased synovial & soft tissue activity. Some immune testing may be more sensitive than others, with results varying with time as well. Read more

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Since one year it take 15 mg methotrexate tablet weekly for rheumatoid arthritis so when I can stop it now my blood test is normal but still have pain?

Since one year it take 15 mg methotrexate tablet weekly for rheumatoid arthritis so when I can stop it now my blood test is normal but still have pain?

Which blood test etc: Methotrexate is a good medication for rheumatoid arthritis but it doesn't cure your arthritis - it works as long as you take it. If you still have pain, it may because of active disease (inflammation), or damage that the arthritis has already caused. You should follow up with a rheumatologist if possible. Read more

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What could a positive ANA of 1:640 speckled indicate if lupus and rheumatoid arthritis tests are negative?

What could a positive ANA of 1:640 speckled indicate if lupus and rheumatoid arthritis tests are negative?

Need more testing: ANA is a screening test. A positive result only indicates more testing might be needed. The speckled portion of the result is not very helpful on its own. About 5% of humans (1 in 20) have a positive ANA for no reason. Read more

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Ra factor very high, but not rheumatoid arthritis? I am 56 women, my RA factor result is super high, is 380, but other testes of related rheumatoid arthritis all normal (including blood testes and x ray). After three month I did all test again, the resul

Ra factor very high, but not rheumatoid arthritis? I am 56 women, my RA factor result is super high, is 380, but other testes of related rheumatoid arthritis all normal (including blood testes and x ray). After three month I did all test again, the resul

Rheumatoid: Rheumatoid arthritis is a disease that requires certain criteria for it s diagnosis. We automatically think that if a test for a disease is positive you have to have the disease, but that is not how it goes. For example there are to types of anti-globulins, igg and igm, they may be positive in different situations for the same disease so one is positive for the acute phase and the other becomes positive later, this is only an example. So things need to be proven to be valid. An is not an automatic concept, if is positive I have it and if not what do I have. There are many things we still need to learn about many diseases and many laboratory results. Rheumatoid factor can go up, with age, with certain infection etc etc if you google it, you will find the complete list. You saw the rheumatologist, and obviously he did a diagnosis based on your clinical picture and is not rheumatoid arthritis, in the same manner he will consider other possibilities for that findings, he would have order additional test if there was a suspicion of another entity that may give a positive rheumatoid factor. Since he evaluated you he would be the best person to ask, rather than to figured out the other way oround, doctors see patients and suspect diseases, and then request labs to confirm the diagnosis or ruled them out, the other way around is difficult and is not how it is usually done. Read more

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My ESR in blood test is 8 mm/h CRP 1.5 mg/L so why still pain in all my body? . 15 mg methotrexate weekly one year for rheumatoid arthritis

My ESR in blood test is 8 mm/h CRP 1.5 mg/L so why still pain in all my body? . 15 mg methotrexate weekly one year for rheumatoid arthritis

Need more info: What areas are involved? How long have you had symptoms? Have you been on a higher dose of methotrexate ever. Maybe add another drug--plaquenil. Sounds like you need to revisit your rheumatologist. Feel better Read more

Dr. Chokkalingam Siva
166 Doctors shared insights

Rheumatoid Factor (Definition)

Rheumatoid factor (rf) is a test that is often sent to evaluate a person with joint pain and stiffness. A positive rf has to be interpreted in the context of the patients symptoms. Sometimes the + rf is false, and not clinically related to the patients symptoms. Rf can be +ve in other conditions such as infections and certain cancers. Some patients with rheumatoid arthritis ...Read more


Dr. Oscar Novick
40 Doctors shared insights

Rheumatism (Definition)

"rheumatism" is an older term, not used much today. Most people are referring to pain and swelling in the joints when they use this term. People may mean something different when they use this term in contrast to when they refer ...Read more