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Doctor insights on: Can You Overdose On Nortriptyline

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What is a lethal dose of nortriptyline for someone who weighs 65 kg? She has a lot of tablets at home and I'm worried that she might try to overdose.

What is a lethal dose of nortriptyline for someone who weighs 65 kg? She has a lot of tablets at home and I'm worried that she might try to overdose.

OD concerns: There is no exact answer as metabolism depends on multiple factors. Nortriptyline is a tricyclic antidepressant and has many different side effects. It is safe at prescribed doses but it is a VERY dangerous drug to take as an overdose. If you have ANY concerns that some is stockpiling or has suicidal idealizations please urge them to seek professional help or call the paramedics or police. ...Read more

Dr. Ravi Chand
243 Doctors shared insights

Nortriptyline (Definition)

Classified as a tricyclic antidepressant, and considered of modest benefit these days due to significant anti-cholinergic side effects (drowsiness, dizziness, dryness of mouth, blurring, and perhaps effect on bladder). Confusion may occur in older folks. Had some value in migraine prevention at one point. Used rarely these days as ...Read more


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How common is nortriptyline used now?

How common is nortriptyline used now?

Nortriptyline: Most tricyclic antidepressants' use in psychiatry has declined since ssris and snris were introduced, with fewer side effects at therapeutic doses to treat depression. ...Read more

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Could nortriptyline be ruining my life?

Could nortriptyline be ruining my life?

Nortriptylene: Generally a doctor would prescribe an antidepressant like nortriptylene to help someone's life, not ruin it. Depression itself can ruin a life! But this medicine can also bring side effects like rapid heart rate, dry mouth, constipation, and sexual problems. If you're having symptoms you think may be related to this medicine, it's time to discuss it with your doctor. Other options are available. ...Read more

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Nortriptyline how do you stop taking it?

Nortriptyline how do you stop taking it?

Not advised: Please do not stop your antidepressant without checking with the prescribing physician. Many conditions that nortriptyline (pamelor) are used to treat tend to recur, especially if the medication is stopped too quickly. Abrupt discontuation of nortriptyline can result in nausea, headache and insomnia and uncommonly even delirium/psychosis. The taper would depend on dose and duration of treatment. ...Read more

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What is the half life of nortriptyline 50mg?

What is the half life of nortriptyline 50mg?

Long time: Half life is a huge range....roughly 16-90 hrs. Could therefore, take as long as 8-10 days for the body to clear an entirely fully dose from the a person. ...Read more

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Please describe the medication: nortriptyline?

Please describe the medication: nortriptyline?

Older antidepressant: Classified as a tricyclic antidepressant, and considered of modest benefit these days due to significant anti-cholinergic side effects (drowsiness, dizziness, dryness of mouth, blurring, and perhaps effect on bladder). Confusion may occur in older folks. Had some value in migraine prevention at one point. Used rarely these days as better meds are available. ...Read more

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Nortriptyline and weight problems, what to do?

Nortriptyline and weight problems, what to do?

Let your prescribing: Physician/ psychiatrist know if you are gaining weight on Nortriptyline. Ensure that you are eating healthfully, physically active and hydrating well. Depending on what you are taking the nortriptyline for - there are likely other medication alternatives as well. Take care. ...Read more

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What happens when I stop taking nortriptyline?

What happens when I stop taking nortriptyline?

Do not stop suddenly: Nortriptyline is a tricyclic antidepressant, available only by prescription. It can make you dizzy or drowsy. Your doctor should monitor your use regularly. Do not stop use suddenly, your doctor will need to decrease you dose gradually before you stop it completely. You may need to stop using it several days before you have surgery. Let any doctor or dentist who treats you know about it. ...Read more

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Interested to know how does nortriptyline make you feel?

Interested to know how does nortriptyline make you feel?

Nortriptylene: If prescribed this medication for depression, the goal is to normalize mood. So within a few weeks of starting nortriptylene, the intent is that you'll feel better. Some side effects may be dry mouth, heart palpitations, and sweating, though. ...Read more

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How long should it take for nortriptyline to take effect?

Time to effect: It will take app. 1-2 weeks to start working. ...Read more

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Are there any weight problems associated with Nortriptyline?

Are there any weight problems associated with Nortriptyline?

Yes: Weight gain is a factor with this entire class of anti-depressants, and with Depression itself. In some cases the relief from depression makes people hungrier, and in other cases the sedation effect from the medicine reduces movement. Very important to manage your diet, exercise, and level of response to the medicine with your doctor. So important that you do not become sedentary. ...Read more

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How long does it take to get nortriptyline out of the system?

How long does it take to get nortriptyline out of the system?

7-10 days: Median half life for nortryptiline is about 25-30 hours. So I average to get out of your system roughly, its about 7-10 days. That's of course is a rough estimate, as there are a lot of variables that van affect the elimination half life. Thanks. ...Read more

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What would you consider a too high of a dose of nortriptyline?

What would you consider a too high of a dose of nortriptyline?

Side effects persist: Established blood level measuring and therapeutic ranges are available to guide dosing and provide feedback if doses threaten safety for example cardiac. Most abandon meds that provide significant side effects. They can be unpleasant but can cause various medical problems in their own right. Weight gain, dry eyes/mouth, urinary hesitancy, sedation, memory problems. All are reversible. ...Read more

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Can you tell me if you've seen anyone who been on nortriptyline?

Yes, many: Yes, I have seen many people who are taking nortriptylene. What is your question? ...Read more

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Nortriptyline - how long does it take to notice that it is helping?

Depends: Depending on the dose. I have had some patients respond after the first dose and some respond after a few days. ...Read more

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Any benefit of taking nortriptyline in the morning rather at night?

Any benefit of taking nortriptyline in the morning rather at night?

Maybe: Most people find it makes them sleepy, so can not take it during the day. If it does not make you sleepy, you could take it during the day. For depression, it would not make any difference when you take it. If you are taking it for headaches or pain, it could help a little better in the morning, but should help well if you take it at night too. ...Read more

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What is it like to be on or know someone who's been on nortriptyline?

Like anyone else: This is an old-fashioned antidepressant that might also be prescribed for other indications. Life's easier and happier if you approach each new person you meet as someone who's a possible friend, teammate, or simply someone to enjoy -- rather than as a group of medical diagnoses or otherwise something strange to be feared. ...Read more

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I have been taking nortriptyline for 4 days (10mg). If I stop how long would it take to get out of my system?

I have been taking nortriptyline for 4 days (10mg). If I stop how long would it take to get out of my system?

9 days: The elimination half life of nortriptyline is about 20 to 90 hours. It takes almost 6 elimination half life's for a drug to be cleared from the human body. Well... It could take a maximum of 540 hours or 8.25 days (6 x 90 hours) for nortriptyline to be completely eliminated. In any case do not discontinue abruptly. Taper down 5mg q3 days. Rec.: consult with your prescribing physician. ...Read more

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Overdose (Definition)

When the maximum dose of medication ...Read more