Doctor insights on:
Can You Overdose On Nortriptyline
What is a lethal dose of nortriptyline for someone who weighs 65 kg? She has a lot of tablets at home and I'm worried that she might try to overdose.
OD concerns: There is no exact answer as metabolism depends on multiple factors. Nortriptyline is a tricyclic antidepressant and has many different side effects. It is safe at prescribed doses but it is a VERY dangerous drug to take as an overdose. If you have ANY concerns that some is stockpiling or has suicidal idealizations please urge them to seek professional help or call the paramedics or police. ...Read more
Classified as a tricyclic antidepressant, and considered of modest benefit these days due to significant anti-cholinergic side effects (drowsiness, dizziness, dryness of mouth, blurring, and perhaps effect on bladder). Confusion may occur in older folks. Had some value in migraine prevention at one point. Used rarely these days as ...Read more
Nortriptylene: Generally a doctor would prescribe an antidepressant like nortriptylene to help someone's life, not ruin it. Depression itself can ruin a life! But this medicine can also bring side effects like rapid heart rate, dry mouth, constipation, and sexual problems. If you're having symptoms you think may be related to this medicine, it's time to discuss it with your doctor. Other options are available. ...Read more
Not advised: Please do not stop your antidepressant without checking with the prescribing physician. Many conditions that nortriptyline (pamelor) are used to treat tend to recur, especially if the medication is stopped too quickly. Abrupt discontuation of nortriptyline can result in nausea, headache and insomnia and uncommonly even delirium/psychosis. The taper would depend on dose and duration of treatment. ...Read more
Older antidepressant: Classified as a tricyclic antidepressant, and considered of modest benefit these days due to significant anti-cholinergic side effects (drowsiness, dizziness, dryness of mouth, blurring, and perhaps effect on bladder). Confusion may occur in older folks. Had some value in migraine prevention at one point. Used rarely these days as better meds are available. ...Read more
Let your prescribing: Physician/ psychiatrist know if you are gaining weight on Nortriptyline. Ensure that you are eating healthfully, physically active and hydrating well. Depending on what you are taking the nortriptyline for - there are likely other medication alternatives as well. Take care. ...Read more
Do not stop suddenly: Nortriptyline is a tricyclic antidepressant, available only by prescription. It can make you dizzy or drowsy. Your doctor should monitor your use regularly. Do not stop use suddenly, your doctor will need to decrease you dose gradually before you stop it completely. You may need to stop using it several days before you have surgery. Let any doctor or dentist who treats you know about it. ...Read more
Time to effect: It will take app. 1-2 weeks to start working. ...Read more
Yes: Weight gain is a factor with this entire class of anti-depressants, and with Depression itself. In some cases the relief from depression makes people hungrier, and in other cases the sedation effect from the medicine reduces movement. Very important to manage your diet, exercise, and level of response to the medicine with your doctor. So important that you do not become sedentary. ...Read more
Median half life for nortryptiline is about 25-30 hours. So I average to get out of your system roughly, its about 7-10 days. That's of course is a rough estimate, as there are a lot of variables that van affect the elimination half life.
Thanks. ...Read more
Side effects persist:
Established blood level measuring and therapeutic ranges are available to guide dosing and provide feedback if doses threaten safety for example cardiac.
Most abandon meds that provide significant side effects. They can be unpleasant but can cause various medical problems in their own right. Weight gain, dry eyes/mouth, urinary hesitancy, sedation, memory problems. All are reversible. ...Read more
Yes, many: Yes, I have seen many people who are taking nortriptylene. What is your question? ...Read more
Depends: Depending on the dose. I have had some patients respond after the first dose and some respond after a few days. ...Read more
Maybe: Most people find it makes them sleepy, so can not take it during the day. If it does not make you sleepy, you could take it during the day. For depression, it would not make any difference when you take it. If you are taking it for headaches or pain, it could help a little better in the morning, but should help well if you take it at night too. ...Read more
Like anyone else: This is an old-fashioned antidepressant that might also be prescribed for other indications. Life's easier and happier if you approach each new person you meet as someone who's a possible friend, teammate, or simply someone to enjoy -- rather than as a group of medical diagnoses or otherwise something strange to be feared. ...Read more
I have been taking nortriptyline for 4 days (10mg). If I stop how long would it take to get out of my system?
The elimination half life of nortriptyline is about 20 to 90 hours. It takes almost 6 elimination half life's for a drug to be cleared from the human body. Well... It could take a maximum of 540 hours or 8.25 days (6 x 90 hours) for nortriptyline to be completely eliminated.
In any case do not discontinue abruptly. Taper down 5mg q3 days.
Rec.: consult with your prescribing physician. ...Read more
How do you know that your nerve problems are getting worse and what can I do to help it? On nortriptyline to help but so far it's not.
Call med prescriber.: If you are not feeling better on nortriptyline from the perspective of mood, sleep, appetite, and energy, then your depression may not be responding to this particular medication. I recommend that you talk with the prescriber of the nortriptyline about other potentially beneficial approaches that you have not yet tried and that may be different in how they treat depression. ...Read more
Generally how long does it take for Nortriptyline to take effect. When should I notice a decrease in pain? I started 10 mg qhs on 7/10/14.
If it works,: Your dosage is too low at this point, but if you can stand the adverse effects, and they will appear, a dose of 150 mg or higher might work within 2-3 weeks at earliest. However, Lyrica (pregabalin) works far better and may be tolerated far better also, if you can get that dose up to high ranges. But what is the cause? Better if you approach therapy and treat underlying disorder. ...Read more
Are there any major side affects on nortriptyline? Start 10mg for week. Then so on & so on till reach 50mg. Wats the updose do? Any mental change?
Not usually major: Nortriptyline is a tricyclic antidepressant (tca) that has been used for decades. Tcas commonly cause dry mouth, constipation, and momentary dizziness upon standing, but rarely anything major. The dose is increased gradually to minimize these side-effects as your body gets used to the medication. Most patients feel better (less depressed) after taking nortriptyline for a few weeks. ...Read more
Been taking nortriptyline for four weeks not liking it neuro said its ok to come off it! I was up to to 50 mgs on the fourth week now went down to 25 mg 3 days now done is that ok?
It depends: If the neurologist was the physician who prescribed the nortriptylene, and s/he feels it's no longer needed, then deciding to stop it sounds reasonable. If not, the original condition could recur when the medicine is stopped. Also, the time frame of dose reductions may be a little quick -- but you haven't been taking it very long. Half-life of nortriptylene is 13- 88 hours. ...Read more
Talk w/psychiatrist: Before making this decision, please discuss it with the doctor who prescribed it for you (hopefully a psychiatrist). Together you need to review the initial problems you were having, and see where you are with them now. Otherwise these could return when the nortriptylene is tapered or stopped. ...Read more
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