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Doctor insights on: Can You Mix Methadone With Cymbalta

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Is 45mg/day of methadone and 60mg/day of cymbalta (duloxetine) safe to take together?

Is 45mg/day of methadone and 60mg/day of cymbalta (duloxetine) safe to take together?

Maybe: Can't answer for you specifically or for exact doses since that would involve doing an individual assessment. However they should be ok together. There is one possible interaction. Methadone may reduce the metabolism of Cymbalta (duloxetine) (meaning that for the same dose your blood levels may be higher than they would ordinarily be). This may mean a dose adjustment. ...Read more

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Dr. Stuart Wasser
645 doctors shared insights

Methadone (Definition)

Methadone is a synthetic opiate used for pain control and in the rehabilitation of opiate addicts. Methadone used in rehabilitation relieves craving, suppresses withdrawal symptoms, and blocks the euphoric effects associated with ...Read more


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Does cymbalta really increase methadone, and Abilify (aripiprazole) increases the cymbalta? If so, is it wise to take these meds together?

Wow! Discuss w/ Dr!: That's a lot of medications and each one brings increased effects of the others with a particular concern in the combo of Cymbalta (duloxetine) and buspirone for serotonin syndrome. Definitely discuss the wisdom w/ your provider but DO NOT stop any of these on your own. Do it under monitoring and consider adding a non-pharma psychotherapy strategy that might help you too. Best ...Read more

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What would be symptoms ofa bad reaction to methadone or interaction of it with cipro (ciprofloxacin) or cymbalta or sudafed?

What would be symptoms ofa bad reaction to methadone or interaction of it with cipro (ciprofloxacin) or cymbalta or sudafed?

Methadone interactio: Cipro (ciprofloxacin) and Methadone together cause problems with cardiac arrhythmias prolonging what's called the qt interval. If you're on this combination then monitoring with an ekg would be a good idea. Cipro (ciprofloxacin) can increase Cymbalta levels. If you are already having side effects from the cymbalta, these will increase. Cymbalta and Methadone together can very rarely cause serotonin syndrome. I would recommend the google that so you know what the symptoms are. There's not enough space here to allow me to write those all out. Best wishes. ...Read more

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My pm doctor wants to switch me from Methadone to Nucynta (tapentadol) for fibromyalgia pain relief. I'm also taking Cymbalta. I don't feel like Nucynta (tapentadol) will work ?

My pm doctor wants to switch me from Methadone to Nucynta (tapentadol) for fibromyalgia pain relief. I'm also taking Cymbalta. I don't feel like Nucynta (tapentadol) will work ?

Research suggests: That use of narcotics in fibromyalgia may be a bad choice in the end and drugs such as Cymbalta, Savella, (milnacipran) and Lyrica offer better longterm success. Yet, the Methadone needs to be handled, and a better switch at this stage would involve suboxone. I agree with you, going to Nucynta may not be a wise decision. Try to see a pain specialist. ...Read more

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Im on 2mg Xanax (alprazolam) tid, 95mg Methadone, 60mg Cymbalta. I have manic depression since my husbands death 2 years ago already had anxiety issues & on Xanax (alprazolam) ?

Im on 2mg Xanax (alprazolam) tid, 95mg Methadone, 60mg Cymbalta. I have manic depression since my husbands death 2 years ago already had anxiety issues & on Xanax (alprazolam) ?

What is the question: What is your question. Apparently you are under care of a psychiatrist and are on large dose of Xanax (alprazolam) and history of narcotic drug addiction as you are on methadone. Consult your doctors who are treating you about any concern you may have. ...Read more

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Can you mix benzoylecgonine and methadone?

Methadone and cocain: You should not be mixing these two together. ...Read more

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Is it dangerous to mix Neurontin (gabapentin) with methadone?

Is it dangerous to mix Neurontin (gabapentin) with methadone?

Sedation: The two in combination may increase somnolence/sedation and as such a decrease in the dose of Methadone may be required (which would generally be a good thing-yes?). ...Read more

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Duloxetine (cymbalta) and alcohol, is it okay to mix?

Maybe: Alcohol and Cymbalta (duloxetine) are both metabolized by the liver. That means when you use them both, the alcohol stays in your system longer than it normally would. So every drink will feel like 2 or 3. It's not that you CAN'T drink, you just need to exercise caution, because you WILL get drunk faster and you WILL stay drunk longer. If, however, you have a history of alcohol or drug problems, NO! Be well ...Read more

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Im taking cymbalta (duloxetine) 30mg and Zoloft 50mg i fell very good with that mix is that ok?

Im taking cymbalta (duloxetine) 30mg and Zoloft 50mg i fell very good with that mix is that ok?

Use with caution: Risperidal, Cymbalta (duloxetine) and Zoloft can interact with each other and on occasion can cause a form of toxicity called the Serotonin Syndrome. These medications elevate serotonin, a neurotransmitter, that enables one neuron(nerve cell) to communicate with another. When mixed together they can cause the serotonin level to go too high. See http://bit.ly/1CvRfjC Do not stop medication on your own. ...Read more

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Taking deplin with cymbalta (duloxetine) and on vicodin is this a bad mix?

Taking deplin with cymbalta (duloxetine) and on vicodin is this a bad mix?

If prescribed, okay: There are no interactions noted between Cymbalta (duloxetine) and vicodin. Deplin is l-methylfolate, a medical food meant to augment your antidepressant (cymbalta) by increasing folate to your nervous system. It is safe to use with these other meds also. ...Read more

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My daughter went to doc she was on cymbalta (duloxetine) 60 she was deepest doc add zoloft 50mg she start to feel good is that oki for doc to do the mix?

My daughter went to doc she was on cymbalta (duloxetine) 60 she was deepest doc add zoloft 50mg she start to feel good is that oki for doc to do the mix?

Doc's the judge.: With these two medications there is a possibility of a major drug-drug interaction leading to what is called Serotonin Syndrome. The doctor must be aware that she is on both medications and weigh the risk/benefits. If they are working, good, but if agitation, rapid heart beat, nausea, hallucinations, fever, incoordination occur call 911. This is an emergency if it happens. Notify the Doctor. ...Read more

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Is it dangerous to mix flexeril, cymbalta, lyrica, (pregabalin) mobic, hyzaar all together? I am taking this every night.

Is it dangerous to mix flexeril, cymbalta, lyrica, (pregabalin) mobic, hyzaar all together? I am taking this every night.

Maybe: Though there are no serious interactions between this combination of medications, it would be important to have your kidney function and electrolytes monitored regularly. Make sure all of your doctors know all of your medications if you see more than one doctor. ...Read more

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Is it dangerous to mix flexeril, cymbalta, lyrica, (pregabalin) mobic, hyzaar all together? I am currently taking these every night?

Is it dangerous to mix flexeril, cymbalta, lyrica, (pregabalin) mobic, hyzaar all together? I am currently taking these every night?

Possibly: Depending on dose, this combination could result in increased bleeding tendency, and serotonin syndrome, which is characterized by high fever, muscle aches, etc. Be sure your doctor knows what and how much you are taking. ...Read more

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How can I tell if I have serotonin syndrome or if i was just sick. I take lithium, cymbalta, (duloxetine) requip, tramadol, trazadone, and klonopin which don't mix.

How can I tell if I have serotonin syndrome or if i was just sick. I take lithium, cymbalta, (duloxetine) requip, tramadol, trazadone, and klonopin which don't mix.

Call psychiatrist: You might start with the prescribing physician who i hope is a psychiatrist with this combination of psychiatric meds. If not, i would recommend you see a psychiatrist asap. ...Read more

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How much methadone is too much for dosage?

How much methadone is too much for dosage?

Any dose that causes: The patient to nod off, act drunk, or stop breathing is too high. When i worked in a Methadone clinic in 1980 in chicago, the average dose was about 45 mg. With the increase in heroin potency, I am seeing patients who have been or are on 200-300 mg a day. ...Read more

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How can methadone work and what exactly is it ?

Long-acting opioid: Methadone is a long-acting opioid. Generally speaking, within any particular class of addictive drugs, the quicker the peak effect, and the shorter the duration of effect, the more addictive a drug will be. Because opioid-addiction can be tough to quit, Methadone - a long-acting opioid with a slow peak of action - can be used to replace the addictive opioid while one works on recovery. ...Read more

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Why is my methadone wearing off for me soo fast?

Chronic: If taking long time it creates own metabolism or some people are ultra rapid metabolized .Talk to your physician. ...Read more

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Why is my methadone wearing off for me soo fast?

Why is my methadone wearing off for me soo fast?

Several reasons: Tolerance, for one. You may need more or a different medicine. Ask you provider. Good luck! ...Read more