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Doctor insights on: Can You Mix Methadone With Cymbalta

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Is 45mg/day of methadone and 60mg/day of cymbalta (duloxetine) safe to take together?

Is 45mg/day of methadone and 60mg/day of cymbalta (duloxetine) safe to take together?

Maybe: Can't answer for you specifically or for exact doses since that would involve doing an individual assessment. However they should be ok together. There is one possible interaction. Methadone may reduce the metabolism of Cymbalta (duloxetine) (meaning that for the same dose your blood levels may be higher than they would ordinarily be). This may mean a dose adjustment. ...Read more

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Dr. Stuart Wasser
638 doctors shared insights

Methadone (Definition)

Methadone is a synthetic opiate used for pain control and in the rehabilitation of opiate addicts. Methadone used in rehabilitation relieves craving, suppresses withdrawal symptoms, and blocks the euphoric effects associated with ...Read more


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Does cymbalta really increase methadone, and Abilify (aripiprazole) increases the cymbalta? If so, is it wise to take these meds together?

Wow! Discuss w/ Dr!: That's a lot of medications and each one brings increased effects of the others with a particular concern in the combo of Cymbalta (duloxetine) and buspirone for serotonin syndrome. Definitely discuss the wisdom w/ your provider but DO NOT stop any of these on your own. Do it under monitoring and consider adding a non-pharma psychotherapy strategy that might help you too. Best ...Read more

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What would be symptoms ofa bad reaction to methadone or interaction of it with cipro (ciprofloxacin) or cymbalta or sudafed?

What would be symptoms ofa bad reaction to methadone or interaction of it with cipro (ciprofloxacin) or cymbalta or sudafed?

Methadone interactio: Cipro (ciprofloxacin) and Methadone together cause problems with cardiac arrhythmias prolonging what's called the qt interval. If you're on this combination then monitoring with an ekg would be a good idea. Cipro (ciprofloxacin) can increase Cymbalta levels. If you are already having side effects from the cymbalta, these will increase. Cymbalta and Methadone together can very rarely cause serotonin syndrome. I would recommend the google that so you know what the symptoms are. There's not enough space here to allow me to write those all out. Best wishes. ...Read more

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My pm doctor wants to switch me from Methadone to Nucynta (tapentadol) for fibromyalgia pain relief. I'm also taking Cymbalta. I don't feel like Nucynta (tapentadol) will work ?

My pm doctor wants to switch me from Methadone to Nucynta (tapentadol) for fibromyalgia pain relief. I'm also taking Cymbalta. I don't feel like Nucynta (tapentadol) will work ?

Research suggests: That use of narcotics in fibromyalgia may be a bad choice in the end and drugs such as Cymbalta, Savella, (milnacipran) and Lyrica offer better longterm success. Yet, the Methadone needs to be handled, and a better switch at this stage would involve suboxone. I agree with you, going to Nucynta may not be a wise decision. Try to see a pain specialist. ...Read more

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Im on 2mg Xanax (alprazolam) tid, 95mg Methadone, 60mg Cymbalta. I have manic depression since my husbands death 2 years ago already had anxiety issues & on Xanax (alprazolam) ?

Im on 2mg Xanax (alprazolam) tid, 95mg Methadone, 60mg Cymbalta. I have manic depression since my husbands death 2 years ago already had anxiety issues & on Xanax (alprazolam) ?

What is the question: What is your question. Apparently you are under care of a psychiatrist and are on large dose of Xanax (alprazolam) and history of narcotic drug addiction as you are on methadone. Consult your doctors who are treating you about any concern you may have. ...Read more

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Can you mix benzoylecgonine and methadone?

Methadone and cocain: You should not be mixing these two together. ...Read more

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Is it dangerous to mix Neurontin (gabapentin) with methadone?

Is it dangerous to mix Neurontin (gabapentin) with methadone?

Sedation: The two in combination may increase somnolence/sedation and as such a decrease in the dose of Methadone may be required (which would generally be a good thing-yes?). ...Read more