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Doctor insights on: Can You Have Lupus With A Negative Ana Test

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Can you be diagnosed with lupus with positive ana, a lot of symptoms for lupus, but negative dsdna?

Can you be diagnosed with lupus with positive ana, a lot of symptoms for lupus, but negative dsdna?

Yes: Though the dsdna is helpful in assessing severity of lupus in some patients, it is not a requirement to have dsdna to be diagnosed with lupus. In fact, laboratory tests help confirm a suspected diagnosis of lupus but lab tests never make or disprove the diagnosis by themselves. ...Read more

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Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more


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I have pos ANA and all other lupus test normal but have symptoms of lupus can you have lupus with only pos ANA test and other lupus test negative?

LUPUS: A low positive ANA alone may be non diagnostic. If all other labs are normal, it can be repeated in a 2-3 mth window. Lupus also has a list of criteria that needs to be met to fulfill the diagnosis. Follow up with your doctor and if still concerned see a rheumatologist. ...Read more

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Can you still have lupus if you have a negative ANA and normal sed rate?

Yes: However, the diagnosis becomes much less likely unless several other diagnostic criteria for lupus are present. ...Read more

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Can you be diagnosed with lupus if you have only positive ANA and symptoms? Even if DNA was negative..?

Can you be diagnosed with lupus if you have only positive ANA and symptoms? Even if DNA was negative..?

Yes: You may have lupus in the absence of a positive anti DNA antibody test. Among other possibilities you may suffer from seronegative lupus. In time the test may become positive. ...Read more

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Can you have ankylosing spondylitis with a negative antibody blood test?

Can you have ankylosing spondylitis with a negative antibody blood test?

Yes: While most people with spondylitis carry the genetic marker called hla b-27, it is not present in 10-20% of spondylitis patients. In that situation, the diagnosis is made by finding typical x-ray, ct or MRI changes in the sacro-iliac joints. Likewise, only 20% of people who carry the b-27 gene ever develop spondylitis or a related condition. ...Read more

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Can you have lupus with a negative ANA test? What about other autoimmune disorders?

Can you have lupus with a negative ANA test? What about other autoimmune disorders?

ANA testing: ANA is a screening test for autoimmune disease, (generally present in 80-90% of cases). A higher titer over 1:160 is more significant. There are more definite testing for lupus such as anti-smith antibody and anti ds dna antbody. There are many more other specific testing for other specific autoimmune disorders. Syphilis and lyme disease can give false positive ANA test as well. See your md. ...Read more

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I have a positive lupus ban test but a negative ANA test. My primary care doctor said I have sero negative lupus and told me not to see a specialist?

I have a positive lupus ban test but a negative ANA test. My primary care doctor said I have sero negative lupus and told me not to see a specialist?

See a rheumatologist: A positive lupus band test on a skin biopsy suggests cutaneous lupus but not necessarily systemic lupus. See a rheumatologist. It is presumptuous for a primary care physician to tell you what he/she did. ...Read more

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I received blood test results with positive RNP and Ana not detected. Is it possible to not have SLE or mctd, or it's definite due to positive RNP?

Ritter: These tests are prone to lab error, and many healthies have one or both positive especially at low titer. These are only one piece of information that your physician will use. ...Read more

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Can you have a positive blood test for arthritis if you are in remission?

Can you have a positive blood test for arthritis if you are in remission?

Hmm..: Not sure to which arthritis you are referring, but if rheumatoid arthritis the answer is yes. The rheumatoid factor will always remain positive whether symptoms are present or not. Ankylosing spondylitis hla b27 test also will remain positive. Those two tests are not a measure of disease activity, just the presence of the disease in an individual. ...Read more

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Can a MCTD diagnosis always change? I tested positive for ANA and Rnp

Maybe: It will depend on how high the titers are and what signs / symptoms you have. Low titers may mean nothing at all. Without clinical evidence of multisystem disease, the diagnosis of MCTD is very, very unlikey ...Read more

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What can cause a positive lupus test without having lupus?

Sometimes drugs: Sometimes drugs can cause a positive lupus test, but the lupus test or ANA is designed to be overly sensitive so as not to miss cases, but the drawback is it can be positive in normal people. Your doctor should be able to handle this problem. ...Read more

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Could a person with 2 different negative ANA tests have lupus?

Yes, but ANA: negative lupus is uncommon. ANA is one of the criteria for diagnosing lupus, but a negative ANA does not rule out lupus. See this site for more info. http://www.webmd.com/lupus/guide/laboratory-tests-used-diagnose-evaluate-sle ...Read more

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Can you have symptoms of lupus years before the ANA test positive?

No: If the ANA and other autoantibodies are negative, it is very unlikely that you have lupus. ...Read more

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Can you still have rheumatoid arthritis with a negative rheumatoid factor test?

Can you still have rheumatoid arthritis with a negative rheumatoid factor test?

Yes: While the vast majority of patients with RA have a positive rf, a certain percentage do not. Typically, the younger the patient, the better the chance the rf may be negative, depsite a clinical diagnosis of ra. ...Read more

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What to do if I have an ANA test of 1250 but peripheral and speckled are negative. could this be a false positive?

No: The test is positive, forget the pattern. The key question is why was the test ordered in the first place? The ANA must always be evaluated in the context of the clinical picture. ...Read more