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Doctor insights on: Can You Have Lupus With A Negative Ana Test

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Can you have lupus with a negative ANA test? What about other autoimmune disorders?

Can you have lupus with a negative ANA test? What about other autoimmune disorders?

ANA testing: ANA is a screening test for autoimmune disease, (generally present in 80-90% of cases). A higher titer over 1:160 is more significant. There are more definite testing for lupus such as anti-smith antibody and anti ds dna antbody. There are many more other specific testing for other specific autoimmune disorders. Syphilis and lyme disease can give false positive ANA test as well. See your md. ...Read more

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Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more


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I had a negative ANA test but positive double stranded DNA test do I have lupus?

Not enough data: The diagnosis of luppus is made on the basis of clinical signs and symptoms confirmed by specific lab tests including the dna antibody. This antibody can also be positive in other auto immune diseases. Since you did not mention symptoms, there is no way to answer your question. ...Read more

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I have a positive lupus ban test but a negative ANA test. My primary care doctor said I have sero negative lupus and told me not to see a specialist?

I have a positive lupus ban test but a negative ANA test. My primary care doctor said I have sero negative lupus and told me not to see a specialist?

See a rheumatologist: A positive lupus band test on a skin biopsy suggests cutaneous lupus but not necessarily systemic lupus. See a rheumatologist. It is presumptuous for a primary care physician to tell you what he/she did. ...Read more

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Is lupus possible with a negative ANA? DR GAVE ME "working" dx due to other neg tests and sx

Is lupus possible with a negative ANA? DR GAVE ME "working" dx due to other neg tests and sx

Yes: There is such a thing as ANA negative lupus. The ANA is nehative in 5-10% of lupus patients. ...Read more

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Can ANA test be false negative for lupus?

Lupus: Has specific criteria for diagnosis, ANA is just one of them and canot be relied on by itself for a diagnosis. ...Read more

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Could a person with 2 different negative ANA tests have lupus?

Yes, but ANA: negative lupus is uncommon. ANA is one of the criteria for diagnosing lupus, but a negative ANA does not rule out lupus. See this site for more info. http://www.webmd.com/lupus/guide/laboratory-tests-used-diagnose-evaluate-sle ...Read more

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I have 10 out of 12 symptoms of lupus but a negative ana. Can my ANA be negative one time and positive another?

ANA negative SLE: About 5% of the patients with systemic lupus are ANA negative. Read the information at the site given below. Please discuss the issue with your doctor sle is not a topic for self diagnosis. http://www.lupus.org/webmodules/webarticlesnet/templates/new_aboutfaq.aspx?articleid=380&zoneid=19. ...Read more

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I have pos ANA and all other lupus test normal but have symptoms of lupus can you have lupus with only pos ANA test and other lupus test negative?

LUPUS: A low positive ANA alone may be non diagnostic. If all other labs are normal, it can be repeated in a 2-3 mth window. Lupus also has a list of criteria that needs to be met to fulfill the diagnosis. Follow up with your doctor and if still concerned see a rheumatologist. ...Read more

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Can you still have lupus if you have a negative ANA and normal sed rate?

Can you still have lupus if you have a negative ANA and normal sed rate?

Yes: However, the diagnosis becomes much less likely unless several other diagnostic criteria for lupus are present. ...Read more

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Positive ANA 1;320 speckled pattern and a negative ena... Does this mean i don't have lupus?

ANA: You really need to meet with a rheumatolgist to discuss this further since they might need further testing or biopsy to determine the answer. ...Read more

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I have had multiple positive ANA and they do the next step tests to check for lupus and it comes back negative. Why do they keep checking my ana?

I don't know: Imo, there is no need to constantly repeat an ana. It is a waste of time and money. Positive is positive and constantly repeating it will not change that. ...Read more

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I recently had a positive ANA test. My dr tested folupus but it was negative. I have all the symptoms except rash. Can u have a false neg lupus test?

I recently had a positive ANA test. My dr tested folupus but it was negative. I have all the symptoms except rash. Can u have a false neg lupus test?

Keep working: Lupus is defined by a series of criteria, of which a strongly positive ANA is one. No specific test turning out negative rules out lupus. Perhaps you were tested for anti-smith(sm), which if positive hands us the diagnosis but is only positive in 1 of 3 patients. Perhaps there is a misunderstanding or you can request consultation. Lupus requires great courage -- will be thinking of you. ...Read more

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Blood test result- ANA by EIA=negative. Is this reassuring as far as lupus or other autoimmune problem?

Mostly: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, your tests are reassuring but do not 100% exclude autoimmune disorders as there are may such disorders that occur without ANA. ...Read more

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What do these mean? lupus anticoagulant weakly present at 1.30; positive ANA Test 1:40 speckled pattern; negative anticardioliptin and beta2

Not much: A weakly present lupus anticoagulant and an ANA of 1:40 are common in the general population, and usually not an indication of an autoimmune disorder. You should visit with the physician who ordered these tests to review them with you however. A test alone does not give any answers. Doctors will need both a patient's history and tests to determine further management. ...Read more

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If I have an elevated CRP and est with a negative ANA what could this indicate? I have type 1 dm and fibromyalgia. They were suspecting lupus

The : The ESR and CRP are both markers of inflammation. However, they are very non-specific and can be elevated in a wide variety of conditions including infections, malignancies, and auto-immune diseases. The ANA is the screening test for lupus and similar conditions. It has many false positives but very few false negatives. In your case, the negative ANA most likely means that you elevated ESR and CRP are not due to lupus. ...Read more

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I have had all lupus symptoms for 6 months but repeated blood tests are showing nothing. Negative ana, ena, normal sed rate etc. I'm so confused?

I have had all lupus symptoms for 6 months but repeated blood tests are showing nothing. Negative ana, ena, normal sed rate etc. I'm so confused?

NOT LUPUS: Seek a second opinion from a rheumatologist. You may have other medical conditions that mimic lupus. You will need additional blood and urine testing. ...Read more

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Any tests that can be done to diagnose lupus when skin rash not active? ANA historically negative. Had biopsy sugg. of early conn. tissue disease.

SLE diagnosis. : The diagnosis of lupus is really clinical, supported by consistent blood test findings. That being said, relevant blood testing for lupus includes ESR, cRP, ANA, dsDNA and anti-Sm. ...Read more

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Negative ANA blood test but positive anti-dsDNA antibodies. Do I have lupus? What causes this? Very symptomatic.

Rheumatologist: This test alone is insufficient to diagnose lupus. It has to be supplemented with appropriate symptoms and physical findings. A rheumatologist is best qualified to evaluate, advise, and treat you, if needed. ...Read more