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Doctor insights on: Can You Have Both The Thalassemia Trait And Sickle Cell Trait

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Can you have both the thalassemia trait and sickle cell trait?

Can you have both the thalassemia trait and sickle cell trait?

Yes and no: If you have the sickle cell mutation on one beta hemoglobin gene and a thalassemia mutation on the second gene, then you have sickle cell beta thalassemia - this is not a trait but a disease. The severity of the disease is dependent upon the size/ location of the thalassemia mutation. ...Read more

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Dr. Sewa Legha
75 doctors shared insights

Sickle Cell Carrier (Definition)

Sickle cell carrier has gen for disease so if get married with some body with the same gene they will have children ...Read more


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If I have sickle cell trait is it possible to now be sickle cell anemia?

If I have sickle cell trait is it possible to now be sickle cell anemia?

Confusing question: SS disease requires the genes for sickle cell from both parents, while S trait has it from one. You cannot change the genetic makeup that you were born with. Someone with trait can have a kid with SS if the partner has trait or SS. ...Read more

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If me and boyfriend both have sickle cell trait, how will we prevent our children from having full sickle cell anemia?

If me and boyfriend both have sickle cell trait, how will we prevent our children from having full sickle cell anemia?

Nothing: Unfortunately, there would be 25% chance for your child to have sickle cell disease and 50% chance for sickle cell trait . With our technology now, nothing can alter the risk. Sorry to say , the only thing for somebody with sickle cell trait to completely prevent any possibility of having a biological child with sickle cell disease is by having a child with somebody with normal hb. ...Read more

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If a child has sickle cell anemia, wouldn't both the parents need to have sickle cell trait?

If a child has sickle cell anemia, wouldn't both the parents need to have sickle cell trait?

No: There are varying forms of sickling diseases, however it is a recessive trait and so the parents may appear fine but carry the trait and yet have a child with the disease. ...Read more

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Do both parents have to have the sickle cell trait for the child to have sickle cell anemia?

Do both parents have to have the sickle cell trait for the child to have sickle cell anemia?

No: 2 abnormal (sickle cell) gene have to be inherited to have sickle cell disease. This can happen if both patents have sickle cell trait, one parent has sickle cell disease or both have sickle cell disease. ...Read more

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Could both parents have to have the sickle cell trait for the child to have sickle cell anemia?

Could both parents have to have the sickle cell trait for the child to have sickle cell anemia?

Yes: Sickle cell anemia requires the gene from both parents to cause ss anemia. If only one parent gave the gene, the kid would be a trait carrier. ...Read more

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Can a father with normal blood and a mother with sickle cell trait have a child with sickle cell anemia?

Can a father with normal blood and a mother with sickle cell trait have a child with sickle cell anemia?

NO: To simplify- providing that the father has a completely normal blood - ( no other type of congenital/hereditary bood disorder-like thalasemia minor, hemoglobin c disease etc) - the baby will have 50% risk to have sickle cell trait-but the baby will not have sickle cell anemia. ...Read more

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Please help! what happens if you have both hemaglobin c trait and sickle cell trait?

Less severe than SS: Hemoglobin sc disease is the second most common type of sickle cell disease. It occurs when you inherit the hb c gene from one parent and the hb s gene from the other. Individuals with hb sc have similar symptoms to individuals with hb ss (sickle cell disease). However, the anemia is less severe. ...Read more

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Is there a treatment available for people with sickle cell trait and alpha thalassemia?

Yes: Hematologists (blood specialists) evaluate persons with both sickle cell trait and Alpha thalassemia disease. The sickling should not be a problem, because the person is only sickle trait, and Alpha thal. Mutations seem to lessen the tendency of blood cells to sickle from the sickle cell mutation. Persons with both sickle trait and Alpha thal. Trait probably won't have symptoms needing treatment. ...Read more

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What is the cause of sickle cell trait?

What is the cause of sickle cell trait?

It is inherited: Hemoglobin (HGB) is a complicated chemical that is in the red blood cells and carries oxygen. We inherit one gene from each parent that makes one of the parts of HGB called beta chains. If we inherit a sickle beta chain gene from one parent and a normal beta chain gene from the other, we have sickle trait. If we inherit a sickle beta chain gene from both parents, we have sickle cell anemia. ...Read more

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What are the symptoms of having the sickle cell trait?

Usually none: Having sickle cell trait means being a carrier for a mutation in one of the hemoglobin genes. It usually does not give any symptoms, but is able to be transmitted to ones children. If the other parent also has sickle cell trait or sickle cell anemia, then the children are at risk for possibly inheriting sickle cell anemia. ...Read more

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Is there a cure for sickle cell trait?

Is there a cure for sickle cell trait?

No: And no cure is needed. With rare exceptions sickle trait has no impact on health and longevity. ...Read more

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Please help? Is the sickle cell trait deadly?

No: The vast majority of patients with sickle cell trait have no health consequences whatsoever. ...Read more

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Could a the sickle cell trait skip generations?

No: Sickle cell trait is when a person has one mutated copy of the beta-hemoglobin gene and one normal copy. You always inherit the mutated hemoglobin from one of your parents. Thus, one parent always has at least sickle cell trait if the child has sickle cell trait. Therefore trait does not skip a generation. ...Read more

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Are there any symptoms of sickle cell trait in babies?

Are there any symptoms of sickle cell trait in babies?

Not really: If it were not for the newborn screening done in all states we would not pick up these kids in childhood. These kids have pretty normal lives. If/ when their parents are aware they carry trait, we would look for it at some point but there would not be any urgency beyond the desire to know. ...Read more

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I was wondering what are the risks of the sickle cell trait?

Check this out:: http://www.cdc.gov/ncbddd/sicklecell/documents/scd%20factsheet_sickle%20cell%20trait.pdf.

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What is sickle cell trait and anemia?

What is sickle cell trait and anemia?

Genes: Sickle cell anemia occurs when someone has 2 sickle cell genes. Normal hemoglobin (hb) genes code for hb a. A sickle cell gene codes for hb s. Having 1 hb a gene & 1 hb s gene leads to sickle trait. This will have no symptoms, but has some health consequences. 2 genes for hb s leads to sickle cell anemia. To make things more complicated, there are other abnormal hb genes that can cause problems. ...Read more

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What causes the sickle cell trait?

It is inherited: Hemoglobin (HGB) is a complicated chemical that is in the red blood cells and carries oxygen. We inherit one gene from each parent that makes one of the parts of HGB called beta chains. If we inherit a sickle beta chain gene from one parent and a normal beta chain gene from the other, we have sickle trait. If we inherit a sickle beta chain gene from both parents, we have sickle cell anemia. ...Read more

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How is the sickle cell trait passed on?

Straightforward: The beta globin gene is on chromosome 11. Everyone has two, one from each parent. If you have sickle trait, one is normal and the other has the sickle mutation. Half your germ cells (eggs or sperm) will carry the normal gene, half the mutated gene. If you give the mutated gene to your child, they have sickle trait. If they get a mutated gene from your partner too, they have sickle cell disease. ...Read more

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Dr. James Ball
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