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Doctor insights on: Can You Have An Autoimmune Disease With Negative Ana

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Does a negative ANA rule out all autoimmune diseases?

Does a negative ANA rule out all autoimmune diseases?

No.: The ANA test is not perfect. It is positive in some people who do not have an autoimmune disease. Also, there are other tests that are important in checking for some autoimmune diseases. Finally, an ANA test (positive or negative) has to be interpreted along with a patient's clinical symptoms under the guidance of a physician. Read more

Dr. Tracy Lovell
495 Doctors shared insights

Autoimmune Disease (Definition)

In auto immune disease the enemy is from with in. As name implies "auto" is self and "immune " is immune system. One 's own immune system for unknown reason turns against self and destroys or damages tissues or cells. List of auto immune disease are many and growing. End result is destruction of of tissues such as thyroid, pancreas or cells such as ...Read more


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If ANA and other blood tests for autoimmune diseases came negative, how do I know I do have one like autoimmune suppressor as doctor say?

Ask your doctor: Hashimoto's thyroidits is an autoimmune disease where there are antibodies to the thyroid gland. Other antibodies such as ANA may develop along with the thyroid antibodies, but only in some patients. Autoimmune suppressor - you may have misunderstood your doctor. Read more

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Esr is elevated but my ANA and CRP are normal! Does this mean that I don't have an autoimmune disease?

Esr is elevated but my ANA and CRP are normal! Does this mean that I don't have an autoimmune disease?

Autoimmune disorders: Esr is an inflammatory marker tha is elevated in inflammatory disorders, anemia, pregnancy, , kidney cancers, tb, lymphoma to name a few. It measures rate at which red cells sediment in a test tube in 1 hour. It is used more to monitor response to treatmemt is such disorders and helps in diagnosis of certain conditions. Esr can be elevated with negative ANA in several autoimmune disorders. Read more

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A positive ANA test 1;320 titer, with a speckled pattern... Does it mean I have an autoimmune disease...

A positive ANA test 1;320 titer, with a speckled pattern... Does it mean I have an autoimmune disease...

Not necessarily: The ANA is a screening test for lupus but is not specific. It can be positive in numerous other diseases and in normal people. It has to be evaluated in the context of the clinical picture and the results of other autoantibody tests. Read more

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I am a 21-year-old female who tested positive ANA but don't have an autoimmune disease; does my weight loss, bruising and night sweats mean leukemia?

I am a 21-year-old female who tested positive ANA but don't have an autoimmune disease; does my weight loss, bruising and night sweats mean leukemia?

Get seen: Maybe one woman in 4 has a positive ANA but seems fine. I'd stop worrying about the ANA. I doubt you have leukemia but you need a complete history and physical exam and basic labs (CBC, chem profile, urinalysis) by a competent physician. Night sweats are serious. Read more

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How likely a diagnosis of an autoimmune disease if Ana was 1.320?

One factor: A positive ANA is one of the many factors in making a diagnosis of an auto-immune disorder. For example a diagnosis of lupus requires four factors out of a list of eleven. You may consult this site for more information: http://www. Lupus. Org/answers/entry/lupus-diagnostic-criteria Read more

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I had the standard blood tests for autoimmune diseases (no symptoms) all the tests came back normal except ANA of pos 1.4. Should I be concerned?

See below: Close to 30% of patients will have positive ana. If you did not have symptoms of autoimmune disease, it is not clear to me why this was performed. Odds are in your favor that you probably have nothing to worry about with you currently reporting no symptoms. Read more

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Which autoimmune diseases cause joint pain headaches and positive ana?

Which autoimmune diseases cause joint pain headaches and positive ana?

Many different: Causes, such as rheumatoid arthritis, lupus, etc. You need to see a rhematologist for accurate diagnosis and treatment. Read more

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What autoimmune diseases may cause raised ALT, ankle pain, chest pain, spine & shoulder pain without ANA, HLA B27 being positive?

What autoimmune diseases may cause raised ALT, ankle pain, chest pain, spine & shoulder pain without ANA, HLA B27 being positive?

Not many: Sounds like you have already had a "work-up" for your symptoms (ANA. HLA B27 are not :common" tests The raised ALT may or may not be associated with your other symptoms. Do you have a liver problem? Hepatitis B, C often cause associated joint problems. Get this checked out by the same Health Care Provider who obtained the blood tests you mention Hope this helps Dr Z Read more

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What autoimmune diseases can cause severe pain in most of a persons bones/muscles/joints? ANA was normal, so PCP says not Lupus. I need suggestions.

What autoimmune diseases can cause severe pain in most of a persons bones/muscles/joints? ANA was normal, so PCP says not Lupus. I need suggestions.

Polyarthritis: Several diseases and conditions can cause polyarthritis. I would suggest you make an immediate in-person appointment with a Rheumatologist to evaluate the range of motion of your joints, any joint changes related to a myriad of causes. Don't guess at your problem. Physicians are taught to diagnose based on your medical history, chief complaint, laboratory tests and imaging. Good luck. Read more

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Possible to have an autoimmune disease w/ very low C-reactive protein & ESR/SED rate? ANA is negative, but doc said he thinks I have something autoimmune going on. I always thought autoimmune diseases were inherently inflammatory in nature?

Yes and No: You are correct that we lump autoimmune and inflammation together. The problem with autoimmune labs is they can change almost day to day. There are certainly more tests then an ANA that can be positive even in light of a negative ANA. A good history and physical exam are more important then labs even though labs and xrays can be helpful and supportive of a diagnosis. Your doctor may be correct Read more

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Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more


Autoimmune (Definition)

The immune system developed to tell our own, normal cells (self) from foreign and abnormal cells (non-self). This lets the immune system eliminate viruses, bacteria, fungi and cancer cells from our body without harming normal cells. Sometimes the immune system fails to tell self from non-self and it attacks normal cells, for example in ...Read more