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Doctor insights on: Can You Explain The Relationship Between Catecholamines And Metanephrines

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Can you explain the relationship between catecholamines and metanephrines?

Can you explain the relationship between catecholamines and metanephrines?

Phenol vs ether: The chemical structure of epinephrine, the natural hormone generated in excess by a pheochromocytoma tumor, has an aromatic carbon ring with two adjacent -oh (phenol) groups and a side-chain amino group. Compounds with this structure are called catecholamines. Metanephrine is a metabolite of this hormone, with one phenol converted to an ether (-och3). If elevated, it implies the tumor. ...Read more

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Dr. Milton Alvis Jr
30 doctors shared insights

Metanephrines (Definition)

Metanephrins are metabolic products of cathecolamines: epinephrin and norepinephrin and can be used to diagnose excess production of these adrenal/sympathetic hormones. They can be measured in blood and urine and are very elevated in a condition called pheochromocytoma which is a tumor found mostly in the adrenal glands ...Read more


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Why do I have to refrain from tobacco for catecholamines  and metanephrine urine test?

Why do I have to refrain from tobacco for catecholamines  and metanephrine urine test?

Nicotine...: Tobacco contains nicotine. Nicotine gives the body its kick because it stimulates the adrenal glands to produce adrenaline. Adrenaline, or epinephrine, is a catecholamine. If you use tobacco, the test may return as a false positive. ...Read more

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Should i redo 24 hrs urine test for catecholamines  metanephrine if i had a cigarette or just give it to lab?

Should i redo 24 hrs urine test for catecholamines  metanephrine if i had a cigarette or just give it to lab?

See below: Urine collection for metnephrines requires a lot of precautions. It would be better to redo. See the website given below for details about precautions or this test. http://labtestsonline.org/understanding/analytes/urine-metanephrine/tab/sample. ...Read more

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Can you tell me about elevated catecholamines?

Can you tell me about elevated catecholamines?

Stress response: Hi. Elevated catecholamines are part of the "fight or flight" response mediated by the sympathetic nervous system in response to a serious threat to your survival. If someone has a tumor that makes catecholamines (pheochromocytoma or paraganglioma), they have elevated catecholamines, and usually bad high blood pressure, palpitations, sweating, headache, and pallor. Interesting stuff! ...Read more

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What to do if everything you know about elevated catecholamines?

What to do if everything you know about elevated catecholamines?

Incomplete sentence: Hi. That's not a complete thought or question. Would you like to clarify it? I can tell you elevated catecholamines can be either physiological (the "fight or flight" response") or pathological (tumors of the adrenal medulla or related tissue). But I can't for the life of me understand what you're thinking or trying to ask. Good luck! ...Read more

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What makes the plasma metanephrine test different? 

What makes the plasma metanephrine test different? 

Different from urine: The plasma test compared to the urine is newer and more sensitive. In other words if you have pheochromocytoma the plasma test is less likely to miss the diagnosis by coming back normal. ...Read more

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