Doctor insights on:
Can You Explain The Relationship Between Catecholamines And Metanephrines
Phenol vs ether: The chemical structure of epinephrine, the natural hormone generated in excess by a pheochromocytoma tumor, has an aromatic carbon ring with two adjacent -oh (phenol) groups and a side-chain amino group. Compounds with this structure are called catecholamines. Metanephrine is a metabolite of this hormone, with one phenol converted to an ether (-och3). If elevated, it implies the tumor. ...Read more
Metanephrins are metabolic products of cathecolamines: epinephrin and norepinephrin and can be used to diagnose excess production of these adrenal/sympathetic hormones. They can be measured in blood and urine and are very elevated in a condition called pheochromocytoma which is a tumor found mostly in the adrenal glands ...Read more
What other conditions can mimic pheochromocytoma? Catecholamines and metanephrines were normal, but I still have all symptoms. Extremely scared.
Would my drinking a lot of water be more likely to cause a false posit or f.Neg, during 24hrurine:catecholamine? Metanephrine &normetane? Creatinine?
Prob won't matter: Those tests are very likely to be detected whether you drank a lot of water or not. ...Read more
What other blood tests (other than catecholamines and metanephrine) would be abnormal with pheochromocytoma? Would CRP or sedrate be high?
Pheocrhomocytoma: The two blood tests you mentioned for catecholoamines and metanephrine are the only 2 I know of. Sed rate is nonspecific. ...Read more
Should I redo 24 hrs urine test for catecholamines metanephrine if I had a cigarette or just give it to lab?
Stress response: Hi. Elevated catecholamines are part of the "fight or flight" response mediated by the sympathetic nervous system in response to a serious threat to your survival. If someone has a tumor that makes catecholamines (pheochromocytoma or paraganglioma), they have elevated catecholamines, and usually bad high blood pressure, palpitations, sweating, headache, and pallor. Interesting stuff! ...Read more
Incomplete sentence: Hi. That's not a complete thought or question. Would you like to clarify it? I can tell you elevated catecholamines can be either physiological (the "fight or flight" response") or pathological (tumors of the adrenal medulla or related tissue). But I can't for the life of me understand what you're thinking or trying to ask. Good luck! ...Read more
Possible tumor: Urine catecholamines are separated into dopamine, epinephrine, norepinephrine, vma, and dopa, among others. Each of these metabolites are differently expressed by certain tumors, often in the adrenal gland, or sometimes in other sites. This gives a guide to where to test further, or what else may be giving rise to the symptoms (often high blood pressure, heart beat abnormalities, etc). ...Read more
Can methylphenidate causehigh lvls catecholamines fractionated blod test? +mking result undifferentiat so hyperadrnrgcpots cannot be diagnosis b/c of med use?
Ritalin (methylphenidate) and POTS: Methylphenidate shows up as methampetamine in a blood test. To DX hyperadrenergic postural orthostatic tachycardia syndrome (pots) would be a clinical issue not primarily based on a blood test. I can see trying methylphenidate for the chronic fatigue aspects of pots, but the best treatment is often regular aerobic exercise. ...Read more
A 24 hr urine catecholamine test is done to help diagnose and susequently resect a tumor in the adrenal glands called a pheochromocytoma which results in BP elevation to very high levels periodically.
It measures the amount of the hormones epinephrine, norepinephrine, metanephrine, and Dopamine in the urine. ...Read more
All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, your result seems to be normal. You may consult this site for more info on this topic.
https://medlineplus. Gov/ency/article/003613.htm ...Read more
Free metanephrine 64, total plasma metanephrine 301 and normetanephrine 237. 3 weeks post total thyroidectomy. Anything to worry about?
Your question cannot be answered unless we know the following:
1. What laboratory did the tests and what are their normal reference ranges.
2. Did you take any medications that could interfere with the assays?
3. Did you have any foods that might interfere with the assays?
Also, why were these tests done? If you are looking for a pheochromocytoma, they might help. Otherwise, probably not. ...Read more
What is the correlation of cortisol and catecholamines? I need to do a 24 hr urine test and both of these are being tested. Many thanks!
Adrenal: They are trying to rule out adrenal over secretion. Both hormones come out of the adrenal glands. ...Read more
Generally this is:
In the context of some other problem.
Adrenal tumors with catecholemine surges just due to the chemicals. Raised blood pressure and risk of circulation cutting off (miscarriage). Drugs of abuse
http://www. Nerdpocalypse. Net/cocaine. Html and methamphetamine can be very dangerous with that.
Thru the main page, you can connect directly to me to ask more detailed questions http://www. Nerdpocalypse. Net ...Read more
BP related hormones: Metanephrines are hormone compounds related to the presence of an endocrine tumor called a pheochromacytoma. These tumors cause hypertension, the metanephrines are elevated in the blood and urine and mark the presence of the tumor. This test should lead to further localization of the tumor and possible removal. ...Read more
Metabolic product: Metanephrins are metabolic products of cathecolamines: epinephrin and norepinephrin and can be used to diagnose excess production of these adrenal/sympathetic hormones. They can be measured in blood and urine and are very elevated in a condition called pheochromocytoma which is a tumor found mostly in the adrenal glands that causes severe hypertension. ...Read more
Metanephrine: You should discontinue Epinephrine and epinephrine-like drugs for at least 1 week before the test, stop using Acetaminophen 48 hours beforehand, and fast for 8-10 hours prior to collection. It is especially important not to have any caffeine containing food (soda, chocolate), coffee (including decaf), tobacco (smoking cigarettes or cigars), tea, or alcohol for at least 4 hours before specimen coll. ...Read more
Should the urine tests still be performed even though the plasma free metanephrine has been done?
Often no: The plasma has more sensitive and more specific and generally adequate (better) in most situations. It would depend if the doctor is more worried about a false positive (finding pheochromcystoma you really don't have), or more worried about false negative (missing the disease when you really have it). Your doctor would decide based on your symptoms which is the bigger worry /risk. ...Read more
24 hour urine catecholamine for a pheo- if a person does not have an episode during the 24 hours would it still show elevated levels. If so how?
Usually, yes: A pheo usually secretes catecholamines continuously, so it is not usually necessary to time the collection. These catecholamines yield a lot of breakdown products (eg. metanephrines). However, in some circumstances, if there is a very high suspicion for pheo and the initial tests are negative, and the attacks are sporadic, a urine collection timed with the episode is reasonable. ...Read more
If mteanephrine, fractionated 24hrurine came back abnormal, what is the likehood that the metanephrine, fractionated blood test will be abnormal to?
High: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, For the diagnosis of pheochromocytoma, 24-hour urine test is better than plasma metanephrine levels. You may consult this site for information: https://www. Urmc. Rochester. Edu/encyclopedia/content. Aspx? Contenttypeid=167&contentid=metanephrines_blood ...Read more
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