Doctor insights on:
Can You Die From Serum Sickness
Unfortunately...Yes: Serum sickness got it's name from reactions after treatments with high doses of horse serum given for treatments snake bites or tetanus. Antibiotics can also cause this. The persons antibodies clump with the foreign serum proteins. These clumps (immune complexes) can clog small blood vessels in the skin, mucous membranes, joints, kidneys and intestines. Fulminant severe reaction can be fatal. ...Read more
Serum sickness is a type of hypersensitivity reaction (type iii immune reaction) that occurs when the immune system develops antibodies to a foreign protein. The antibody and the foreign protein combine to form an immune complex (ic) that can settle in areas of the body such as the joints or the kidney. The ic can damage these areas and cause arthralgias ...Read more
Yes: Serum sickness can lead to organ damage and vascular collapse if the offending agent is not stopped. Normally however it is a self-limited syndrome which resolves after the offending agent is removed. ...Read more
Yes: The most common treatment for serum sickness is discontinuation of the offending drug, combined with the use of both antihistamines and glucocorticoids. Withdrawal of the drug by itself is usually sufficient treatment for patients with mild symptoms. Fever and joint pains resolve within 48 hours. To prevent recurrence, the culprit drug should be avoided in the future, if possible. ...Read more
Serum Sickness: Serum sickness is a reaction that is similar to an allergy. The immune system reacts to medications that contain injected proteins used to treat immune conditions. Or it can react to antiserum, the liquid part of blood that contains antibodies given to a person to help protect them against germs or poisonous substances. ...Read more
Serum sickness: Classic serum sickness is caused by administration of a protein antigen from a non-human species. There have been some case reports implicating the drugs Rituximab and Infliximab (used to treat chron's disease and rheumatoid arthritis). Rarely, repeated blood transfusions, insect stings, and mosquito bites can cause serum sickness-type reactions. ...Read more
Hypersensitivity: Serum sickness is a type of hypersensitivity reaction (type iii immune reaction) that occurs when the immune system develops antibodies to a foreign protein. The antibody and the foreign protein combine to form an immune complex (ic) that can settle in areas of the body such as the joints or the kidney. The ic can damage these areas and cause arthralgias and glomerulonephritis for example. ...Read more
Similar: Both are type III hypersensitivity or allergic reactions that occur from antibody antigen complexes. The arthus reaction typically occurs after an injection into the skin and the reaction is vasculitis at the site. Serum sickness commonly follows an oral ingestion (like a drug) and symptoms are more general with fever, rash, joint aches, lymph node swelling and sometimes protein in the urine. ...Read more
Yes, and more: Remicade (infliximab), as any foreign protein, can cause a number of adverse effects. It is "humanized", meaning part of it comes from cells that originally were of mice. Our body can produce antibodies to Remicade in our blood that can be measured in specialty laboratories. Even if a patient develops such antibodies, there are ways to help tolerate Remicade or use alternative medications. ...Read more
What part of the classical complement pathway is affected in chronic serum sickness? I read that C3 was low in this case. Anything else in general?
See below: C3, c4, and ch50 can be low in serum sickness. ...Read more
My 3 yr old had sever serum sickness in june. Her entire body swelled / joints had red marks. She still complains about pain. Is this common?
Yes-possible: Serum sickness is a self-limited disorder, ; symptoms resolve with time as the immune complexes are cleared from the system. The use of antihistamines, nonsteroidal anti-inflammatory drugs (nsaids), and corticosteroids helps to ameliorate the symptoms. Symptoms like your comment about pain can last 1-2 weeks. Nsaids are given to relieve this pain. See an allergist/immunologist if still concerned. ...Read more
4yr old son has serum sickness, hives are getting worse and ankles are swollen, ive been giving him ben. And mot. Is there something else for itching?
I've taken three dosages of bactrum ds can I still end up having serum sickness? My left hand hurts right on the top. For no apparent reason. That's why I was wondering
Serum sickness develops with sulfa drugs after a period (usually long term) of treatment!
FURTHERMORE serum sickness joint pain is SYMMETRICAL. ...not just with L hand/wrist!
Hope this helps!
Dr Z ...Read more
Is it possible to have serum sickness without presence of fever? (3 yr old, onset 12 days after starting amoxicillin, itchy rash and swollen joints)
Usually not possible: fever is present in almost all cases, could there be exceptions, yes, but also it could be something else other than serum sickness, hard to make a diagnosis or suggest treatment on this platform, you need to see her doctor or a doctor who can guide you well, ? Order some lab tests and imaging studies after careful history and physical exam, good luck ...Read more
Any blood loss: Or failure to absorb iron appropriately.Get a more detailed answer ›
Not paradoxical: The problem is that copper can't get out of certain cells. The reason for ceruloplasmin being low is under study; since it carries copper, this metal also tends to be low. Checking serum copper and serum ceruloplasmin as a screen for wilson's misses up to a quarter of cases, especially if the person is already sick with anything. ...Read more
Even small dose of b complex making me more anxious nd jumpy. Although I hv anxiety disorder. My serum b 12 is 590.Shud I cont b conplex?
Need tests: Most cases of wilson disease show symptoms between childhood and early adulthood, some may present in their 30's and 40's. Diagnosis is made by blood, urine tests and an eye examination for kayser-fleischer rings (copper deposit around the cornea). Liver biopsy and genetic tests are also options. Not all patients experience the same set of symptoms or timeline, so thorough testing is important. ...Read more
Liver Dr's-Is it JUST fibrosis that can be assessed/likely diagnosed from the serum marker tests like ELF, or other disease also? Thanks
Fibrosis/cirrhosis: Although the most accurate way to assess fibrosis or cirrhosis is with liver biopsy (LB), it is invasive and therefore not used routinely. Three non-invasive tests are now used to assess scarring, two blood tests FibroTest and Enhanced Liver Fibrosis (ELF), as well as a scan, FibroScan or transient elastography (TE). The accuracy compared to LB is less, more accurate for cirrhosis than fibrosis ...Read more
My Crestinine serum level is 1.01 but the range is 0.57-1.00 does this mean I have kidney disease or failure, please explain? Please help
NO: The test is NORMAL. Move on and don't worry. ...Read more