Doctor insights on:
Can You Die From Pernicious Anemia
B12 deficiency: It is an autoimmune disease in which your body develops antibodies against intrinsic factor and gastric parietal cells which are needed to absorb b12, a vital nutrient. These patients will need to get im injections of b 12 lifeterm since they cannot absorb B12 naturally from their diet. ...Read more
Not usually.: Classical pernicious anemia is caused by auto-antibodies against intrinsic factor-producing parietal cells of the stomach. Treatment is lifelong vitamin B12 administration, which is safer than using immunosuppressive medications that could lead to severe infections. Other kinds of B12 deficiency can possibly cured depending on the cause. ...Read more
Cobalamin therapy: Try a trial of vitamin B12 (cobalamin) first and have a physician to repeat lab to ensure adequate dose. Also it may need additional therapies for cobalamin deficiency due to underlying diseases involving intestine or pancreas. Please check for Folic Acid deficiency as well and this may be related to nutritional deficiency. If you are a vegetarian, please take vitamin B12 daily. ...Read more
Probably no: If you have pernicious anemia you do not absorb B12 effectively. That is easily fixed with either B12 injections or large B12 oral doses daily. Unfortunately, patients with B12 deficiency often have other associated autoimmune issues that develop. In general though, pa alone will not shorten life as long as you treat it correctly. ...Read more
Autoimmune disease: Pernicious anemia is an autoimmune disease producing autoantibodies against intrinsic factor found in the lining of the stomach. This leads to lack of absorption of vitamin B12 which is important in making blood cells and for nourishment of the nervous system. Treatment would be by replacement of B12 via injections or absorption into the body by other means (nasal spray). ...Read more
Due 2 B12 deficiency: It is a decline in the amount of red cells in the circulation as a result of impaired production in the bone marrow resulting from a lack of vitamin b12. This is most commonly as a consequence of impaired absorption due to an autoimmune condition affecting the stomach lining. If untreated, it may also lead to brain and spinal cord problems. It is easily treatable with replacement therapy. ...Read more
B-12 deficiency: Unless there is an intestinal parasite, we usually just do blood studies to confirm and supplement vitamin b-12 using 1000 mcg injected monthly, i.M. Some pts will absorb sufficient amounts by mouth or intranasal routes, but most efficient to inject. ...Read more
Methadone is a very strong opioid medication, with a long list of serious side effects. But pernicious anemia is NOT one of them.
Contact your doctor for specific information about your case, re your anemia and specific doses of methadone you are taking. Anemia may be related to other meds you are taking, or an underlying illness. Check with your MD. ...Read more
No: Unaware of any association. True pernicious anemia is an autoimmune disease, caused by antibodies to the cells in our stomachs that produce intrinsic factor, which is needed to absorb vitamin B12 from our intestines. It may be hereditary or acquired. There are other causes of B12 deficiency, including stomach and intestinal diseases/surgery, and lack of B12 in diet. A hematologist can help. ...Read more
Certainly: Pernicious anemia is due to vitamin B12 deficiency. Alcohol in many ways can contribute to B12 deficiency: 1. Interferes with b vitamin absorption - alcoholics also do not have enough b vitamins in their diet 2. May cause gastritis leading to poor acid secretion in stomach (acid helps B12 absorption) 3. May cause intestinal damage leading to malabsorption. Thus, better to avoid alcohol! ...Read more
It can: Pernicious anemia (a severe type of vitamin B12 deficiency) can cause memory problems, irritability, and dementia. Dementia goes beyond having memory problems, and can include difficulties with understanding, reasoning, handling multi-step tasks, and can be accompanied by personality changes. Symptoms generally improve with treatment. ...Read more
The other way around: Achlorhydria (lack of adequate gastric acid production and secretion) is one of the causes of pernicious anemia and not the other way around. Normal gastric acid is essential for adequate absorption of vitamin b-12. Vitamin b-12 deficiency in turn causes pernicious anemia. ...Read more
Not at all: Pernicious anemia results from poor dietary uptake of vitamin b12, usually from a loss of certain cells in your stomach. These cells secrete intrinsic factor, necessary for absorption of vitamin b12. Treatment is B12 shots, potentially. Leukemia is cancer. Treatment is chemotherapy. ...Read more
See below: B-12 anemia is a deficiency in vitamin b-12 (cobalamin). Pernicious anemia is a deficiency or lack in intrinsic factor (produced by cells in the stomach) which is a protein essential for absorption of vitamin B12 in the ileum (small intestine). Pernicious anemia requires replacement of intrinsic factor &/or b-12. B-12 anemia needs only b-12 supplementation. ...Read more
It is easy to Diagno: Pernicious anemia is caused by Vitamin B12 deficiency. Therefore a Blood test can measure the B12 level in the blood and give you/your doctor the answer to your question. It is usually associated with larger sized red cells (Macrocytic Anemia) and bone marrow shows megaloblasts. ...Read more
Can you clarify?: If you have pernicious anemia and aren't effectively treated, you will first lose your mind and then your life. If by "B12 intolerance" you simply mean you cannot absorb the vitamin orally, this is common and you'll need monthly injections. If you believe that the supplement makes you sick -- as it claimed on some "pop" websites -- I'm skeptical but you'll need to get specialist consultation. ...Read more
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