Doctor insights on:
Can Statins Cause Elevated Creatinine Levels
Yes: While very uncommon, all of the statin drugs have been known to cause muscle injury. The release from injured muscle of a substance called myoglobin can plug up the kidneys and cause the creatinine to rise. However, under those circumstances there is usually significant muscle pain or weakness and often the urine has a reddish appearance. Also a muscle enzyme (CPK) will be strikingly elevated. ...Read more
Several drugs exist which lower cholesterol by inhibiting an enzyme in liver cells (hmg-coa reductase) that is involved in cholesterol synthesis. These all have generic names that end in -statin, e.g. Atorvastatin (lipitor) and Simvastatin (zocor). Since nearly all of the meds in this class have been shown to have similar cardiovascular benefits, we often discuss them ...Read more
Do statins have any role in increasing serum creatinine? I well controlled DM type2 on oral antidiabetics and Hypertension controlled Ca channel block
Maybe at high doses: LIMITED data has suggested that statins at higher doses, i.e. more than 40 mg simvastatin a day, might contribute to acute renal failure. This is counter intuitive because, in general, the effects of statins would be very favorable for those at risk for renal failure, such as yourself, with Type2 DM & hypertension. Most experts still recommend statins in this situation unless pt on dialysis. ...Read more
I have moderately elevated cholesterol levels, and am prescribe statin drugs. Which control it nicely, but cause erectile dysfunction. Alternatives?
Different dose or me: Compliance with medication is affected when problems arise, especially ed. Try switching to a different statin, lower the dose & combine with another cholesterol medication. Consider a stress test b/c ED and coronary artery blockage are connected. Decrease your animal fat including dairy and eat more plants. Add coq10 200mg to help with statin side effects and fish oil to help with triglyceride. ...Read moreSee 1 more doctor answer
Astt 88 ALT 188 non smoker occasional drinker 50 yo female on statins..Any other cause for the elevation? Never been elevated before
Combination: It may be a combination of factors. Discuss with your pcp. He may suggest some other tests, including an ultrasound of your liver. ...Read more
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