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Can Sickle Cell Trait Cause Pain
An inherited blood disease causing red blood cells to be sickle (curved) shaped instead of round. It shortens life expectancy, and can result in bacterial infections, painful swelling of the hands and feet, fever, arthritis, leg ulcers, fatigue, anemia, eye damage, and ...Read more
Yes: In a study from the 90's, fetal distress in labour was seen in 17% and 11.5% were delivered by emergency caesarean section. Compared with a comparable group of women without sickle cell trait, the mean birthweight of the babies (3202 g) was not reduced. The main maternal complications were recurrent urinary tract infections (6%) and haematuria (16.5%). ...Read more
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Yes and no: If you have the sickle cell mutation on one beta hemoglobin gene and a thalassemia mutation on the second gene, then you have sickle cell beta thalassemia - this is not a trait but a disease. The severity of the disease is dependent upon the size/ location of the thalassemia mutation. ...Read moreSee 2 more doctor answers
It is inherited: Hemoglobin (HGB) is a complicated chemical that is in the red blood cells and carries oxygen. We inherit one gene from each parent that makes one of the parts of HGB called beta chains. If we inherit a sickle beta chain gene from one parent and a normal beta chain gene from the other, we have sickle trait. If we inherit a sickle beta chain gene from both parents, we have sickle cell anemia. ...Read more
Sickle cell trait: Sickle trait means one copy of hemoglobin carries the mutation for sickle cell disease and the other copy is unaffected. Most people with sickle trait are unaffected by this. For athletes with sickle trait, it is essential to keep well hydrated. See http://www.Cdc.Gov/ncbddd/sicklecell/traits.Html for good recommendations. ...Read more
Sickle trait: Sickle trait means one copy of hemoglobin carries the mutation for sickle cell disease and the other copy is unaffected. Most people with sickle trait are unaffected by this. For athletes with sickle trait, it is essential to keep well hydrated. See http://www.Cdc.Gov/ncbddd/sicklecell/traits.Html for good recommendations. ...Read more
Yes: Hydre increases a type of hemoglobin called fetal hemoglobin in sicle cell patients and this prevents the sickle cells from breaking up easily. Hydrea (hydroxyurea) can reduce need for transfusions and patients may have less pain crises, chest sydrome and other complications. ...Read moreSee 1 more doctor answer
Sickle cell Trait: can offer some protective value regarding severity of malarial disease. In a person who has sickle-cell trait – the red blood cells are destroyed prematurely before the Plamodium can reproduce. According to one study “Sickle cell trait provides 60% protection against overall mortality. Most of this protection occurs between 2-16 months of life, before the onset of clinical immunity..." ...Read moreSee 2 more doctor answers
Most less severe: Most are less severe in sickle cell thalassemia, but depends. HbS/B(0)thal: similar to HbSS in severity maybe slightly less severe. HbS/B(+)thal: has 60% HbSS and 30% HbA, thus less severe than HbSS (sickle cell alone). HbS/A-thal: less severe than HbSS due to decreased HbSS amount. ...Read more
Yes: A bone marrow transplant can replace the cells responsible for creating sickle cells with cells that produce normal hemoglobin. This is a very difficult and dangerous procedure that can lead to significant complications and death. This is why it is not routinely used to treat sickle cell anemia. Research is ongoing in attempts to have people with sickle cell anemia make normal blood cells. ...Read more
Yes: Individuals with sickle cell anemia are at high risk to develop invasive bacterial infections, e.g., meningitis and bacteremia, especially by pneumococcus. Penicillin prophylaxis, immunization, and prompt medical attention for febrile illness have greatly reduced fatality from serious infection. ...Read moreSee 1 more doctor answer
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