Doctor insights on:
Can Poison Cause Amyloidosis
Yes and no: Amyloidosis is the deposition of fibrils of proteins that have been produced by a variety of causes. The causes can be infectious inflammatory or neoplastic. So each case of amyloidosis has its underlying cause, but different cases of amyloidosis can be caused by different underlying processes that produce these circulating proteins. ...Read more
Help please, my doctors think I have cryoglobulinemia that is linked with amyloidosis. What is the cause of this?
3 broad: Cryoglobulinemia associated with amyloid is generally due to 1 of 3 causes: 1: an immune blood cell disorder (such as multiple myeloma) 2: an infection (like hepatitis C) or 3: a "connective tissue" immune disorder such as lupus. Therapy is quite specific for each cause. You should talk with your MD to determine which type of specialist might be needed to clarify the exact cause and best Rx. ...Read more
No: I would look for a different cause. Some amyloidosis (famously amyloidosis al, made from light chains) is caused by a subtle or not-so-subtle proliferation of plasma cells; this may be treated with marrow suppressors. In an older person, "hypoplastic marrow" may be from sampling a place where marrow was a bit scant; the blood picture's key here. Your physicians know more. Good luck. ...Read more
Would alternating bouts of diarrhea/constipation caused by undiagnosed AL amyloidosis be chronic or come and go? I get this for 1-3 days/month only. Bowels normal most of the time. Several biopsies ok, but elevated K/L ratio despite K/L both in range
Not amyloid: Sorry, Brad. You're 32 years old and way too young for this. The K/L ratio is set, like most labs, so that a few percent of healthies fall outside. The pathologist who read the biopsies will be happy to stain them up for amyloid if your physician requests, but as a pathologist myself, I think it's a waste of money. It's also progressive and not intermittent like you have. ...Read more
If a person is in chronic renal failure awaiting transplant, would that not be the cause for amyloidosis? Neg in marrow, awaiting fat byopsy..
Light chains elevated. Kappa 300 mg/dL lambda 200. Creat 1.5 CRP 1, ana 160:1. No MM. What diseases can cause this, rule out secondary amyloidosis?
Chronic inflammation: Chronic inflammation from any cause can cause increase in serum immunoglobulins, polyclonal hypergammaglobulinemia and many of those patients have elevated serum free light chains. Some of these patients even have abnormal K/L ratio which you do not. The results you described are not diagnostic of any illness. ...Read more
Yes: Involvement of blood vessels makes them fragile. ...Read more
People with chronic inflammatory conditions, e.g., chronic osteomyelitis, crohn's disease; patients with multiple myeloma; some with hereditary disorders can develop amyloidosis. See this site for more info.
http://www. Mayoclinic. Org/diseases-conditions/amyloidosis/basics/definition/CON-20024354 ...Read more
It depends on the type of amyloidosis. Primary systemic amyloidosis can be treated with chemotherapy. Secondary amyloidosis requires treating the inciting cause. Genetic variations may have some therapies such as transplant.
Please ask your question with more details. ...Read more
The tests for Amyloidosis include:: B type natriuretic peptide, Biopsy, Bone marrow biopsy, Cardiac MRI without contrast, Complete blood count, Comprehensive metabolic panel, Electrocardiogram, Genetic testing, Troponin, 24 hour urine collection, Beta 2 microglobulin, Immunofixation and immunoglobulins, Urine immunofixation, Echocardiogram. ...Read more
NO: There is no particular diet that helps amyloidosis. However, those with renal/kidney involvement may have to follow a diet that limits protein, sodium, potassium, phosphorus and fluids. When a patient has cardiac involvement, the situation is different and exercise may be more important. ...Read more
Funky protein: There are several types of amyloid which is an abnormal protein made by the body. When amyloid deposits into normal tissue such as skin, joints, liver, heart, etc, the condition is known as amyloidosis. Symptoms vary depending on what part of the body is effected. Consider going to an academic center to have it diagnosed and treated, because of its complexity and rarity. ...Read more
No: Amyloidosis is actually a constellation of illnesses characterized by the deposition of protein fragments in various tissues of the body. The prognosis and treatability of the illness depends upon the type of fragments, the amount of amyloid material and the specific sites of deposition. Hope this helps. ...Read more
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