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Doctor insights on: Can Poison Cause Amyloidosis

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Does amyloidosis have a particular cause?

Does amyloidosis have a particular cause?

Yes and no: Amyloidosis is the deposition of fibrils of proteins that have been produced by a variety of causes. The causes can be infectious inflammatory or neoplastic. So each case of amyloidosis has its underlying cause, but different cases of amyloidosis can be caused by different underlying processes that produce these circulating proteins. ...Read more

Dr. Keith Stockerl-Goldstein
542 Doctors shared insights

Amyloidosis (Definition)

An abnormal protein made by the body. Symptoms vary depending on the part ...Read more


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Help please, my doctors think I have cryoglobulinemia that is linked with amyloidosis. What is the cause of this?

Help please, my doctors think I have cryoglobulinemia that is linked with amyloidosis. What is the cause of this?

3 broad: Cryoglobulinemia associated with amyloid is generally due to 1 of 3 causes: 1: an immune blood cell disorder (such as multiple myeloma) 2: an infection (like hepatitis C) or 3: a "connective tissue" immune disorder such as lupus. Therapy is quite specific for each cause. You should talk with your MD to determine which type of specialist might be needed to clarify the exact cause and best Rx. ...Read more

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Does amyloidosis cause a loss of bone marrow?

Sometimes: Amyloid can be deposited in the marrow and can in some cases thereby compromise the ability of the marrow to form new blood cells. ...Read more

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Can amyloidosis cause a hypoplastic bone marrow?

No: I would look for a different cause. Some amyloidosis (famously amyloidosis al, made from light chains) is caused by a subtle or not-so-subtle proliferation of plasma cells; this may be treated with marrow suppressors. In an older person, "hypoplastic marrow" may be from sampling a place where marrow was a bit scant; the blood picture's key here. Your physicians know more. Good luck. ...Read more

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What is the best way to get rid of the dark skin caused by lichen amyloidosis?

What is the best way to get rid of the dark skin caused by lichen amyloidosis?

Difficult: Topical steroids and bleaching cream helps. Please see your dermatologist for evaluation and to discuss treatment options. ...Read more

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How can darknesses in my hands and bach caused by macular amyloidosis be cured? What's other simptoms of this disease? What's the cause?

Amyloidosis: This is caused by a deposit of an abnormal protein. This is a chronic condition. The treatments are to relieve symptoms but are not a cure. This site provides some information.
http://www. Dermnetnz. Org/systemic/amyloidosis.html. ...Read more

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Would alternating bouts of diarrhea/constipation caused by undiagnosed AL amyloidosis be chronic or come and go? I get this for 1-3 days/month only. Bowels normal most of the time. Several biopsies ok, but elevated K/L ratio despite K/L both in range

Would alternating bouts of diarrhea/constipation caused by undiagnosed AL amyloidosis be chronic or come and go? I get this for 1-3 days/month only. Bowels normal most of the time. Several biopsies ok, but elevated K/L ratio despite K/L both in range

Not amyloid: Sorry, Brad. You're 32 years old and way too young for this. The K/L ratio is set, like most labs, so that a few percent of healthies fall outside. The pathologist who read the biopsies will be happy to stain them up for amyloid if your physician requests, but as a pathologist myself, I think it's a waste of money. It's also progressive and not intermittent like you have. ...Read more

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Light chains elevated. Kappa 300 mg/dL lambda 200. Creat 1.5 CRP 1, ana 160:1. No MM. What diseases can cause this, rule out secondary amyloidosis?

Chronic inflammation: Chronic inflammation from any cause can cause increase in serum immunoglobulins, polyclonal hypergammaglobulinemia and many of those patients have elevated serum free light chains. Some of these patients even have abnormal K/L ratio which you do not. The results you described are not diagnostic of any illness. ...Read more

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Inflamed doudnem stomach, scope done no cause found. Tongue smooth & inflamed on and off. Muscle twitches.22 years old Does it sound like amyloidosis?

Inflamed doudnem stomach, scope done no cause found. Tongue smooth & inflamed on and off. Muscle twitches.22 years old Does it sound like amyloidosis?

No: It is not feasible to provide a meaningful opinion without taking additional history, physical examination and may be some tests. It would be prudent to see your doctor and discuss if you may be depressed. Counter-intuitive as it may seem, exercise may help. Start with low intensity exercise such as walking and gradually increase the intensity at tolerated.
Wish you good health! - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex, if you have sex.
Get HPV vaccine ...Read more

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How does someone get amyloidosis?

Multiple ways: People with chronic inflammatory conditions, e.g., chronic osteomyelitis, crohn's disease; patients with multiple myeloma; some with hereditary disorders can develop amyloidosis. See this site for more info.

http://www. Mayoclinic. Org/diseases-conditions/amyloidosis/basics/definition/CON-20024354 ...Read more

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Is it possible to treat amyloidosis?

Primary amyloidosis: It depends on the type of amyloidosis. Primary systemic amyloidosis can be treated with chemotherapy. Secondary amyloidosis requires treating the inciting cause. Genetic variations may have some therapies such as transplant.
Please ask your question with more details. ...Read more

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What are some of the tests for Amyloidosis?

The tests for Amyloidosis include:: B type natriuretic peptide, Biopsy, Bone marrow biopsy, Cardiac MRI without contrast, Complete blood count, Comprehensive metabolic panel, Electrocardiogram, Genetic testing, Troponin, 24 hour urine collection, Beta 2 microglobulin, Immunofixation and immunoglobulins, Urine immunofixation, Echocardiogram. ...Read more

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Is there a special diet that helps amyloidosis?

Is there a special diet that helps amyloidosis?

NO: There is no particular diet that helps amyloidosis. However, those with renal/kidney involvement may have to follow a diet that limits protein, sodium, potassium, phosphorus and fluids. When a patient has cardiac involvement, the situation is different and exercise may be more important. ...Read more

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What is the definition or description of: amyloidosis?

What is the definition or description of: amyloidosis?

Funky protein: There are several types of amyloid which is an abnormal protein made by the body. When amyloid deposits into normal tissue such as skin, joints, liver, heart, etc, the condition is known as amyloidosis. Symptoms vary depending on what part of the body is effected. Consider going to an academic center to have it diagnosed and treated, because of its complexity and rarity. ...Read more

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What are some of the risk factors for getting Amyloidosis?

The risk factors for getting Amyloidosis include:: Infection, Inflammatory bowel disease, Familial Mediterranean fever, Monoclonal gammopathy of undetermined significance. ...Read more

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Is amyloidosis always fatal?

No: Amyloidosis is actually a constellation of illnesses characterized by the deposition of protein fragments in various tissues of the body. The prognosis and treatability of the illness depends upon the type of fragments, the amount of amyloid material and the specific sites of deposition. Hope this helps. ...Read more

Dr. Alan Ali Dr. Ali
3 doctors agreed:
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Can amyloidosis be treatable?

Dr. Alan Ali Dr. Ali
3 doctors agreed:
Can amyloidosis be treatable?

Amyloidosis: Although no cure, symptoms can be treated with chemotherapeutic agents such as cytoxan, (cyclophosphamide) steroids such as dexamethasone, peripheral blood stem cell transplantation, liver transplantation, & treating the underlying conditions that might have caused it. ...Read more

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How can I address primary amyloidosis?

Prednisone, etc..: There is apparently no specific therapy for this. If there is an underlying cause, it should be treated. Otherwise, Prednisone and/or an chemotx., like Dexamethasone and Bortezomib or melphalan. Autologous bone marrow transplant with stem cell rescue can be done but patients are often too weak for this. It also depends on how bad it is and how much you might be willing to tolerate. ...Read more

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Would st john's wort help primary amyloidosis?

No: There are no clinical trials that support this. The treatment for primary amyloidosis uses certain chemotherapy drugs. ...Read more

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What tests are used to diagnos primary amyloidosis?

Biopsy definitive: The evaluation will look at the history, physical, imaging, laboratory. The are extra antibodies and increased amyloid proteins in the blood. Tissue samples will show the amyloid protein. ...Read more

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What is a good online support group for amyloidosis?

Arthritis Foundation: Check with the arthritis foundation and with the american college of rheumatology they may know online support group for amyloidosis.
There is a prof at boston u who has done research on amyloidosis and she may be able to help patient. ...Read more

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Can amyloidosis interact with certain pain medications?

Can amyloidosis interact with certain pain medications?

Unknown: Amyloid presents as primary and secondary forms. It has been linked in families and is related to abnormally folded proteins. It stands to reason that drugs, foods, environment that is pro-inflammatory may worsen the disease. As to specific medications, like narcotic analgesics or anti-epileptic drugs used to reduce nerve pain, I am unaware of any evidence of interactions. ...Read more

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What is the fastest rate at which primary amyloidosis can spread?

Amyloidosis: The type of amyloidosis determines the rate of spread. Most are slow over time. Amyloid secondary to neoplasms may be the most rapidly progressing types. ...Read more

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Is average lifespan shorter for a person with familial amyloidosis?

Yes: But it depends on which type of familial amyloidosis; some are relatively benign (and the risk comes from other associated diseases), others directly impact longevity. ...Read more

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What are the symptoms of cryoglobulinemia that is linked with amyloidosis?

What are the symptoms of cryoglobulinemia that is linked with amyloidosis?

Cryoglobunliemia: May have no symptoms if cryo levels are low. Cryos can accumulate in the tissues, especially blood vessels. Excess bruising (purpura) on the skin is seen and sometimes a vasculitis (inflammation of the small blood vessels) - especially the lower extremities. Occassionally with very cold weather the fingers may get dark due to sludging. This could even cause damage of the finger tips. So keep warm! ...Read more

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I have attacks that last from 1-3 days every 6 months - 1 year, I'm a heterozygous FMF and I have high level of amyloidosis, could my pain be FMF?

May be: FMF is part of the auto inflammatory syndromes. Heterozygoustiy in some cases has been linked to clinically significant FMF attacks. FMF episodes typically include fever, joint pain and swelling and pleurisy. Don't have enough information about the pain to make any connection currently. ...Read more

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What are the common treatments for amyloidosis?

What are the common treatments for amyloidosis?

Depends on the type: There are different types of amyloidosis that require different types of therapy. There are genetic, inflammatory/infectious and neoplastic (cancer) types cuases of amyloidosis. The treatment is very different depending on the type.
If you ask the question again with the type of amyloid we can be more specific. ...Read more

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What is cutaneous amyloidosis macular?

A skin condition: Macular describes the localized rash (spots) that occur with amyloid. As it is a deposition disease, they are actually amyloid deposits. ...Read more

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Could amyloidosis be mistaken for alzheimer's disease?

Could amyloidosis be mistaken for alzheimer's disease?

Depends: Alzheimer's disease may be considered to be amyloidosis of the brain. There is also peripheral amyloidosis that affects the heart and other organs but is caused by deposition of a different amyloid. ...Read more

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Is amyloidosis in the liver genetic?

It can be: Tough to answer in this format. There are 2 major types of amyloid: 1) al, and 2) aa. Al is due to a type of blood cell cancer (plasma cell), and aa is due to a wide variety of diseases that cause chronic inflammation (rheumatoid arthritis, chronic infections, among others).

Most genetic studies have focused on how people form amyloid lesions, and there is some suggestion that this can be genetic. ...Read more

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What are the signs of amyloidosis?

What are the signs of amyloidosis?

Variable: Black eyes, vascular fraility, kidney damage, breathing difficulty, neurologic damage, airway damage. There are a variety of patterns. ...Read more

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What are the tests for amyloidosis?

Biopsy: Clinical suspicion and biopsy of the suspected organs, followed by examination of the tissue by a pathologist is usually needed to establish a diagnosis of amyloidosis. ...Read more

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What sort of problem is amyloidosis?

Protein deposition: Amyloidosis refers to the deposition of a type of protein into certain organs. There are different subtypes of amyloid proteins depending on the cause. Amyloidosis can be of hereditary, infectious, inflammatory and neoplastic types. ...Read more