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Doctor insights on: Can Neurofibromatosis Type 1 Progress To Neurofibromatosis Type 2

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Help! Is it possible to have a lot of cafe au lait spots and not have neurofibromatosis?

Help! Is it possible to have a lot of cafe au lait spots and not have neurofibromatosis?

Possible: NIH diagnostic criteria for NF1 with two or more of following features:1)6 or more café-au-lait macules over 5 mm in diameter prepubertal individuals over 15 mm in greatest diameter in postpubertal..2) 2or more neurofibromas or one plexiform neurofibroma.3)Freckling in armpit or groin areas4)Optic glioma (optic nerve tumor)5) > 2 Lisch nodules(iris of eye)6)typical bone lesions 7)1deg relative nf1 ...Read more

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Dr. Gerald Mandell
156 doctors shared insights

Neurofibromatosis (Definition)

Neurofibromatosis is a genetic condition characterized by caf_ au lait spots, which are pigmented patches of skin, and benign ...Read more


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Can neurofibromatosis type 1 progress to neurofibromatosis type 2?

Can neurofibromatosis type 1 progress to neurofibromatosis type 2?

NO : Tow distinct gene mutations. Neurofibroma nf i & nf ii are both inhirted tppe i will show cutaneous, neurological and ortho malformations.Tend to be non cancerous nf ii is less frequent ( i in 40000 ) less skin lesions more neuroligical tumors, like maningiomas, bil aucoatic neuromas, schiwanomas, gliomas is part of misme syndrome. ...Read more

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My son has neurofibromatosis type 1 and he is only 2 years old. What symptoms can I expect?

NF 1 is caused by : mutations of the NF gene, 17q11.2. Clinical course varies widely depending largely on location & size of brain, skin, eye & other tumors. Initial evaluations by a geneticist, ped. neurologist, ped. ophthalmologist, developmental/behavioral pediatrician. & Early Intervention, http://www.dds.ca.gov/EarlyStart/home.cfm., guide management. Learning Disabilities & ADHD are common. See www.ctf.org. ...Read more

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What do you suggest if my son has neurofibromatosis type 1 and hi is only 2years old what can I expect ?

What do you suggest if my son has neurofibromatosis type 1 and hi is only 2years old what can I expect ?

See genetics special: Since you are on the internet at this site, I'm sure you have already educated yourself about the risks of learning disabilities, vision issues, cancer, high blood pressure, seizures, skin tumors etc. The complications can be very diverse, and many children have limited issues. A genetics specialist would be better suited to discuss this with you, and direct you to the appropriate specialist ...Read more

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Would neurofibromatosis type 1 disqualify me from donating sperm to a sperm bank?

Would neurofibromatosis type 1 disqualify me from donating sperm to a sperm bank?

Probably: As you know, neurofibromatosis type 1 (nf1) can affect some people mildly, but in others it can cause serious birth defects. The chance that a sperm donor might pass the nf1 mutation to his biological child is 50% for each pregnancy. This would probably be considered an excessively high risk, so i suspect that sperm (and egg) donors with confirmed nf1 would not be invited to donate. ...Read more

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What to do if I have neurofibromatosis but I ain't show if it's type 1 of type 2 does anyone know how 2 find out?

What to do if I have neurofibromatosis but I ain't show if it's type 1 of type 2 does anyone know how 2 find out?

Physician for help: Neurofibromatosis,inherited,with varying involvement from mild to severe.Neurofibroma is benign tumor that originates from the nerve cells.Tumors usually arise from nerves in or under skin.Type1 usually appears in children with brown flat skin spots, freckling in armpits, and soft tumors under skin and sometimes bone deformity.Type 2 usually brain tumors,vestibular schwannomas,acoustic neuromas. ...Read more

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How long can someone with neurofibromatosis type 2 live?

Neurofibromatosis: It depends on how severely affected the patient is with the disorder. The earlier the diagnosis and the most number of lesions and location (particularly in the spine and brain) diagnosed can affect how long someone will live. In my practice I have adults doing well in the midlife yet have lost patients to the disorder as teenagers so it is very variable. ...Read more

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Can a person with neurofibromatosis type 2 die young?

NF-2: The average life expectancy for someone with NF2 is 65 years of age with appropriate screening and intervention. ...Read more

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Can you tell me about the life expectancy of a person with neurofibromatosis type 2?

Shortened: Life expectancy for people with NF-2 is generally shortened compared to non-affected and NF-1 affected people, but it is also highly dependent on a number of potential conditions, and available treatments. I've added a link that is more comprehensive, and I hope it helps. http://www.ctf.org/pdf/brochures/NF2_Info_for_Patients_Families.pdf ...Read more

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