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Can Myelodysplastic Syndrome Be Cured
Pre Leukemia (Myelodysplastic Syndrome) (Definition)
A bone marrow disorder which causes low blood counts (anemia and low white cells and platelets) and a tendendency to develop leukemia. There are several different forms of MDS and many different types of treatment. Hematologists and oncologists specialize in treating this condition. The diagnosis is made by performing a bone marrow biopsy. ...Read more
See below...: Myelodysplastic syndrome (mds) is not a procedure but a form of bone marrow cancer that is generally less aggressive than leukemia but still malignant. Mds usually evolves more slowly then leukemia and sometimes can transform into acute leukemia and become more aggressive and faster evolving. It can be treated with chemotherapy or bone marrow transplant but sometimes treatment is not necessary.See 2 more doctor answers
MDS: Myelodysplastic syndrome (mds) is a bone marrow disorder which causes low blood counts (anemia, and low white cells and platelets) and a tendendency to develop leukemia. There are several different forms of mds and many different types of treatment. Hematologists and oncologists are the doctors that specialize in treating this condition. The diagnosis is made by performing a bone marrow biopsy.See 2 more doctor answers
If myelodysplastic syndrome is mainly caused by exposure to certain elements. How long ago would that exposure have been?
MDS Carcinogens: Alkylating chemotherapies can cause MDS 5-7 years from last dose. Radiation can cause MDS 10-40 years after last dose. Although it's debatable whether modern radiation therapy can cause MDS (see my PubMed article: 24577814). Benzene can cause bone marrow aplasia, MDS or AML 4-14 years after exposure. Tobacco (benzene et al) smoking is significantly associated with MDS with onset 10-20 years.See 1 more doctor answer
See below...: The bone marrow is usually hypercellular (high cellularity) in mds, similar to leukemia. However, unlike leukemia, most of these abnormal cells cannot get out of the marrow into the peripheral blood (ineffective hematopoiesis). Consequently, the peripheral blood cell counts are abnormally low (cytopenia), unlike leukemia where the white blood cell count is usually highly elevated.See 1 more doctor answer
Myelodysplasia: The typical bone marrow features seen in myelodysplastic syndrome can include a hypercellular marrow (the marrow is too full of cells although in some cases the bone marrow can be more empty (hypocellular). There is typically disorder growth of cells so that they do not mature normally (dypsoiesis). Also, many times the chromosomes (cytogenetics) of the bone marrow cells will be abnormal.
See below...: The bone marrow (where blood elements are produced) has high cellularity in mds, similar to leukemia. However, unlike leukemia, most of these abnormal cells cannot get out of the marrow into the peripheral blood (ineffective hematopoiesis). Consequently, the peripheral blood cell counts are abnormally low (cytopenia), unlike leukemia where the white blood cell count is usually highly elevated.See 1 more doctor answer
See below...: Myelodysplastic syndromes (mds) represent a group of bone marrow cancers similar to leukemias in many respects but usually with a less aggressive evolution. Like many other types of cancer, treatment includes chemotherapy and sometimes bone marrow transplantation; however, if the mds is low grade sometimes treatment is not necessary, at least not initially (watchful waiting).See 1 more doctor answer
Bone Marrow Biopsy: Pancytopenia is a clinical condition that can be caused by a variety of diseases such as aplastic anemia, myelodysplasia, drug toxicity. Myelodysplasia is a clinical syndrome that may manifest itself as pancytopenia. A bone marrow biopsy is the only way to tell what is going on.See 1 more doctor answer
See below...: Both monoclonal gammopathy of undetermined significance (mgus) and myelodysplastic syndrome (mds) are disease entities that may be managed by watchful waiting. If your physician is a hematologist/oncologist then he or she probably has significant experience with these diseases and manages them accordingly.See 2 more doctor answers
Diagnosis: For certain patients, genomic sequencing can help establish a diagnosis of mds, especially those without large chromosomal abnormalities. In addition, sequencing can be used to help monitor for response to treatment. There are also limited data to suggest that certain mutations can be useful in prognosis. This is an emerging field of medicine and hopefully your oncologist can help guide you.See 1 more doctor answer
My husbands mother wad diagnosed with myelodysplastic syndrome in her mid 50's, passed away she was deficient of chromosome 8. Is this hereditary?
Probably not: Even though a history of mds in first degree relatives may slightly increase the overall risk to develop mds, the risk is still minimal and these diseases are usually not hereditary.See 1 more doctor answer
Side effect: This is a side effect of some chemotherapy agents. This side effect does not happen to everyone. It is important to follow up with your medical oncologist after treatment is complete so they can keep track of your blood cell counts. If have concerns that you may have developed this, speak to your doctor.See 3 more doctor answers
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