Doctor insights on:
Can Multiple Myeloma Spread To Lungs
Blacks in US: Twice the incidence in african americans than caucasians. Some families have a higher incidence. ...Read more
I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more
Pl suggest any alternative remedy/ies for multiple myeloma I am 48 yer old and no m band seen at this moment after 6 months of chemo?
Homeopathy, herbs ;: There are no proven alternatives for multiple myeloma but that does not mean they may not help; but I would continue standard treatments too. A healthy diet, tonifying herbs, reducing body burden of heavy metals ; other environmental toxins, stress reduction ; working to clear unresolved anger/grief etc. Can only help. I also advise classical homeopathy with a good homeopath. See comments for more:. ...Read more
Blood/Urine/Imaging: Usually workup involves blood and urine tests (spep / upep - serum and urine protein electrophoresis). The preferred initial imaging study is the skeletal survey (x-ray of multiple sites of the body including skull, axial skeleton, and proximal long bones). Bony lesions are usually lytic. ...Read more
The tests for Multiple myeloma include:: Albumin, Basic metabolic panel, Bone marrow biopsy, Complete blood count, Ionized calcium, Lactate dehydrogenase, MRI, Skeletal survey, C reactive protein, Protein electrophoresis, 24 hour urine protein electrophoresis, Free kappa lambda light chains, Beta 2 microglobulin. ...Read more
Plasma cell cancer:
Multiple myeloma is a cancer of plasma cells (pcs). Pcs are the specialized b lymphocytes that produce antibodies. When there is a cancer or one (mono-) clone (= monoclonal, m) PC population they can product m-proteins. Symptoms include crab - hypercalcemia, renal (kidney) insufficiency, anemia, bone disease; also infection and pain.
More: http://www. Cancer. Net/cancer-types/multiple-myeloma. ...Read more
None: If truly smoldering myeloma, there are no signs. If there are symptoms, then it may be myeloma. Hope this helps. ...Read more
Treatment for multiple myeloma has improved markedly and drug treatment alone or drug treatment with auto or donor stem cell transplants can produce decades long remissions. See this site for more info.
http://www. Mayoclinic. Org/diseases-conditions/multiple-myeloma/basics/definition/con-20026607 ...Read more
Asymptomatic: Smoldering myeloma is a stage of Myeloma before patients become symptomatic. So it is discovered on routine checking of blood proteins or show up in a serum protein electrophoresis (SEP). Many of these patients develop symptoms within one or two years and the symptoms are bone/back pain or a broken bone due to myeloma. ...Read more
Yes - RR 2.0 to 4.0:
Relative risk (rr) incr mgus 2.8, myeloma 2.9, lpl/wm 4.0, cll 2.0. From landgren et al.
http://www. Ncbi. Nlm. Nih. Gov/pubmed/19182202
the myeloma cytogenetics are reviewed in greenberg et al. May 2013 -- http://www. Ncbi. Nlm. Nih. Gov/pubmed/23647020. ...Read more
Yes/No: In a sense all cancer is "genetic" involving changes to the DNA or epi-genetic - changes to DNA modifiers such as methylation. A related question is is multiple myeloma inherited. The answer is sometimes. The risk is about double with a family history. Here is one clinical trial studying this: https://clinicaltrials. Gov/ct2/show/NCT00582621 ...Read more
Yes. Not common.: Yes. Multiple myeloma can effect any organ. However, liver involvement is not common. Myeloma generally involves the bones predominantly; however there are reports of nearly every organ being involved in including the brain. Liver involvement by any cancer can make some types of chemotherapy (that is processed by the liver) more difficult to give. ...Read more
There are many options. One source of updated, risk-stratified treatment are the Mayo Clinic Stratification for Myeloma And Risk-adapted Therapy (mSMART) guidelines:
http://www. Msmart. Org/msmart_mar09_002.htm
Treatment depends on disease (MM) and host (patient) characteristics as well as the goals of therapy. ...Read more
None specific for MM: For multiple myeloma, you need to work with a hematologist-oncologist. Homeopathy is a whole different way of addressing imbalance ; helps @ deeper level. You'll need an experienced homeopathic doctor who's also able to communicate clearly with your other physicians. Homeopathic remedies are prescribed for the specific individual rather than the pathologic diagnosis -- 3000-4000 are possible. ...Read more
Usually not: The liver is not usually affected by myeloma however clusters of myeloma cells can rarely deposit in the liver. These are called plasmacytomas. ...Read more
Myeloma specialist: There are many treatment options for multiple myeloma. You should get your father to an oncologist who specializes in multiple myeloma. There are a few good websites with information about myeloma. Try the multiple myeloma research foundation, and the International myeloma foundation or the leukemia and lymphoma society. ...Read more
The myeloma: Family is a proliferation of plasma cells, which produce antibodies or immunoglobulins. Igm is ass. Ociated with waldenstrom macro globulin, igg is the most familiar, but there is also iga, these further produce subunits, kappa and lambda chains. The abnormal clone usually is a xerox machine gone bad producing a copy of one of these chains. Myeloma causes problems by these cells destroying bone. ...Read more
Depends on heart: The light chain deposition disease is unlikely to affect survival. In fact a review of myeloma and kidney failure published last year demonstrated no change in outcome in myeloma patients with or without kidney failure. The biggest predictor of outcome is response to chemotherapy. Velcade (bortezomib) (new chemo) has been a game changer. In addition, patients with cardiac involvement do very poorly. ...Read more
Depends: If you have M protein from another class of immunoglobulin, then the cells producing this M protein would crowd out the other immunoglobulin producing cells in the bone marrow leading to a lower level of what that cell would ordinarily produce. Some Multiple myeloma cases are of no medical significance but needs to be followed. Many myeloma patients are prone to bacterial infections. ...Read more
Part of the disease: Whenever you have smoldering myeloma of certain type, say IgG for example, the other antibody types like IgM and IgA are often decreased. It is just part of the disease process to see a paradoxical lower of other antibody types that are not involved in smoldering myeloma. ...Read more
Stop doing this: You're 31 years old and too young to have myeloma. You're going to see the points where vessels enter the bone and think they're the punched-out lesions. They aren't. If you are concerned that you have myeloma, get a serum and urine protein electrophoresis. If normal, your symptoms have some other cause. Don't do this to yourself. ...Read more
What is the prognosis (chance of recovery) for multiple myeloma and other plasma cell cancer types?
Better than before: Most patients can now achieve remission either with standard therapy or stem cell transplant. The remissions can be long lived although patients are not cured. Many live a decade or more with good quality of life and this time line continues to get longer with the new targeted therapies. The average life span used to be 2.5 years. ...Read more
If I need treatment now, what are my options for multiple myeloma and how successful are they likely to be?
It depends...: An international team has put together guidelines on when patients with myeloma should be treated. Your cancer doctor should be aware of them. There are many things now which can predict how well you will do with treatment and what type of treatment you should have. Patients live much longer with this disease than a decade ago. Some over 20 years making this a chronic illness in many ways. ...Read more
Y total portin 8.2 normal to 8.3 albumin 3.8 and normal to 4.8 mean globulin is high could it be to multiple myeloma?
Not necessarily: In most cases of elevated globulin, no multiple myeloma is present. Globulin elevation is often non-specific and can be present in cases of inflammation such as colds, infections, etc. To rule in multiple myeloma, there must be certain globulin fractions present. Electrophoresis of the blood and/or urine will be able to determine that. ...Read more
Mytotal portin 8.2 normal to 8.3albumin3.8and normal to 4.8 mean globulin is 4.4 could it be to multiple myeloma? Tot ca is 9.2, ion ca is 1.15 ESR 12
Diagnosed with multiple myeloma in the year 2013 after VCD is on scr since Dec 2013. Taking Thalidomide 50 for the last three yrs. Whether to continue?
Ask your doctor advi: Your treating doctor would have an opinion about this question. If you have any side effects from Thalidomide, you can take a break (Drug Holiday) for a few months. Another (sister) drug is more commonly used for maintenance therapy these days, instead of Thalidomide). it is called Revlimid or Lenalidomide. It is less toxic and more active. Discuss with your oncologist. ...Read more
Deoxygenated blood enters the lungs from the right side of the heart and travels to the lungs. When you inspire, oxygen flows into the lungs, transverses the capilliares and attaches to hemoglobin down a gradient. At the same time, co2 diffuses into the capilaries and is expelled with exhalation. Oxygen rich blood then flows to the left side of the heart and into the ...Read more
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