Doctor insights on:
Can Multiple Myeloma Affect The Liver
Blacks in US: Twice the incidence in african americans than caucasians. Some families have a higher incidence. ...Read more
This organ plays a major role in metabolism and has a number of functions in the body, including glycogen storage, decomposition of red blood cells, plasma protein synthesis, hormone production, and detoxification. It lies below the diaphragm in the abdominal-pelvic region of the abdomen. It produces bile, an alkaline compound which aids in digestion via the emulsification of ...Read more
Yes. Not common.: Yes. Multiple myeloma can effect any organ. However, liver involvement is not common. Myeloma generally involves the bones predominantly; however there are reports of nearly every organ being involved in including the brain. Liver involvement by any cancer can make some types of chemotherapy (that is processed by the liver) more difficult to give. ...Read more
Usually not: The liver is not usually affected by myeloma however clusters of myeloma cells can rarely deposit in the liver. These are called plasmacytomas. ...Read more
The myeloma: Family is a proliferation of plasma cells, which produce antibodies or immunoglobulins. Igm is ass. Ociated with waldenstrom macro globulin, igg is the most familiar, but there is also iga, these further produce subunits, kappa and lambda chains. The abnormal clone usually is a xerox machine gone bad producing a copy of one of these chains. Myeloma causes problems by these cells destroying bone. ...Read more
Pl suggest any alternative remedy/ies for multiple myeloma I am 48 yer old and no m band seen at this moment after 6 months of chemo?
Homeopathy, herbs ;: There are no proven alternatives for multiple myeloma but that does not mean they may not help; but I would continue standard treatments too. A healthy diet, tonifying herbs, reducing body burden of heavy metals ; other environmental toxins, stress reduction ; working to clear unresolved anger/grief etc. Can only help. I also advise classical homeopathy with a good homeopath. See comments for more:. ...Read more
My 80 yr husband has multiple myeloma. He won't eat. Can walk, but lies in bed or couch all day. Dr. will not discuss 'stage'. I know he is failin?
2nd opinion v hospic: Check out http://www. Mayoclinic. Org/diseases-conditions/multiple-myeloma/basics/treatment/con-20026607 for info on multiple myeloma and its treatments. Get a 2nd opinion (or change physicians - your Family Doc can help you find Oncologist who accepts your/his insurance). If no treatment is desired, consider hospice for comfort/palliative care. Again, your Family Doc can refer or you can ask on own ...Read more
I'm suffering from seizures after stopping thalidomide. I've used other to stop them but they won't go away. A Multiple Myeloma patient?
? Relationship.: Thalidomide has neurological side effects but is not commonly thought to cause seizures. In fact, early studies suggested thalidomide might have anti-seizure activity. Myeloma does not commonly cause seizures either, although it might contribute to seizures if it causes electrolyte abnormalities or a skull tumor involves the surface of the brain. Work with your doc to evaluate and treat seizure ...Read more
Blood/Urine/Imaging: Usually workup involves blood and urine tests (spep / upep - serum and urine protein electrophoresis). The preferred initial imaging study is the skeletal survey (x-ray of multiple sites of the body including skull, axial skeleton, and proximal long bones). Bony lesions are usually lytic. ...Read more
The tests for Multiple myeloma include:: Albumin, Basic metabolic panel, Bone marrow biopsy, Complete blood count, Ionized calcium, Lactate dehydrogenase, MRI, Skeletal survey, C reactive protein, Protein electrophoresis, 24 hour urine protein electrophoresis, Free kappa lambda light chains, Beta 2 microglobulin. ...Read more
Plasma cell cancer:
Multiple myeloma is a cancer of plasma cells (pcs). Pcs are the specialized b lymphocytes that produce antibodies. When there is a cancer or one (mono-) clone (= monoclonal, m) PC population they can product m-proteins. Symptoms include crab - hypercalcemia, renal (kidney) insufficiency, anemia, bone disease; also infection and pain.
More: http://www. Cancer. Net/cancer-types/multiple-myeloma. ...Read more
None: If truly smoldering myeloma, there are no signs. If there are symptoms, then it may be myeloma. Hope this helps. ...Read more
Treatment for multiple myeloma has improved markedly and drug treatment alone or drug treatment with auto or donor stem cell transplants can produce decades long remissions. See this site for more info.
http://www. Mayoclinic. Org/diseases-conditions/multiple-myeloma/basics/definition/con-20026607 ...Read more
Asymptomatic: Smoldering myeloma is a stage of Myeloma before patients become symptomatic. So it is discovered on routine checking of blood proteins or show up in a serum protein electrophoresis (SEP). Many of these patients develop symptoms within one or two years and the symptoms are bone/back pain or a broken bone due to myeloma. ...Read more
Yes - RR 2.0 to 4.0:
Relative risk (rr) incr mgus 2.8, myeloma 2.9, lpl/wm 4.0, cll 2.0. From landgren et al.
http://www. Ncbi. Nlm. Nih. Gov/pubmed/19182202
the myeloma cytogenetics are reviewed in greenberg et al. May 2013 -- http://www. Ncbi. Nlm. Nih. Gov/pubmed/23647020. ...Read more
Yes/No: In a sense all cancer is "genetic" involving changes to the DNA or epi-genetic - changes to DNA modifiers such as methylation. A related question is is multiple myeloma inherited. The answer is sometimes. The risk is about double with a family history. Here is one clinical trial studying this: https://clinicaltrials. Gov/ct2/show/NCT00582621 ...Read more
There are many options. One source of updated, risk-stratified treatment are the Mayo Clinic Stratification for Myeloma And Risk-adapted Therapy (mSMART) guidelines:
http://www. Msmart. Org/msmart_mar09_002.htm
Treatment depends on disease (MM) and host (patient) characteristics as well as the goals of therapy. ...Read more
None specific for MM: For multiple myeloma, you need to work with a hematologist-oncologist. Homeopathy is a whole different way of addressing imbalance ; helps @ deeper level. You'll need an experienced homeopathic doctor who's also able to communicate clearly with your other physicians. Homeopathic remedies are prescribed for the specific individual rather than the pathologic diagnosis -- 3000-4000 are possible. ...Read more
Myeloma specialist: There are many treatment options for multiple myeloma. You should get your father to an oncologist who specializes in multiple myeloma. There are a few good websites with information about myeloma. Try the multiple myeloma research foundation, and the International myeloma foundation or the leukemia and lymphoma society. ...Read more
I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more