Doctor insights on:
Can Mold Cause Leukemia
A malignant hematologic neoplasm that originates in the bone marrow and represents a clonal proliferation of hematopoietic elements belonging to any of the myeloid, lymphoid, erythroid, and megakaryocytic lineages. Of note, other hematologic neoplasms like lymphoma or myeloma may demonstrate a leukemic phase without actually originating in the bone marrow ...Read more
Variant of CML: This is a variant of chronic myelogenous leukemia. It is the consequence of an acquired mutation in the marrow, but what causes THAT is unknown. ...Read more
Lots of causes:
Are you on any new medicines or supplements? Purpura are raised red/purple spots on the skin. There are many causes of purpura, some are serious. Discovering the cause may take some time, but it is important to find out why. Here's a good discussion of the causes and the workup:
http://www. Nlm. Nih. Gov/medlineplus/ency/article/003232.htm
Never worry until you have to. Wastes energy. Go play! ...Read more
SIMPLE ANSWER: There is no specific symptom. Symptoms vary, for example: fevers, night sweats, weight loss, fatigue, weakness and shortness of breath to name a few. Initial best test is a: CBC - complete blood count. For CML there has been a chromosomal translocation known as bcr/abl resulting in what is known as the philadelphia chromosome. Treatments are oral tyrosine kinase inhibitors that target c-kit. ...Read more
Yes, in some cases: Radiation can be used to treat leukemia in certain situations. It can be used as part of the leukemia treatment in preparation for a stem cell transplant. It can also be used to treat leukemia that has spread to the spinal fluid or formed a mass of leukemia cells outside the bone marrow. ...Read more
What causes leukemia? What is the treatment like? Is it a long term and continuous treatment? Is it going to cost a lot?
Depends: There are many types of leukemia and many types of treatment for each type. Some require just observation alone, otheres require aggressive, multiagency chemotherapy. Treatment can be quite expensive. Your best bet is an academic center that has extensive experience correctly diagnosing, treating and managing leukemia. ...Read more
Random mutations...: Occur in our body's cells because they are not able to correct all of the millions of DNA damage events that naturally occur during our life. In the event that a bone marrow progenitor cell gets hit with an unlucky series of mutations then a leukemic cell will be made, and grow out of control. Familial susceptibility, or exposures (e.g. chemotherapy, radiation, or benzene) may increase this risk. ...Read more
Rarely causes pain: It is uncommon to have pain as a symptom of leukemia. But if you have it then it is likely to be from the bones, most often from the pelvic/low back area. But you should know what type of leukemia you are dealing with (?) as there are 4 different types which can be either acute or chronic leukemia, with entirely different symptoms from one to the other (s). ...Read more
See below...: Exposure to certain chemicals like benzene or formaldehyde may increase the risk for cancer including leukemia. This is probably due to the mutagenic effect of these agents, meaning they can induce mutations in otherwise normal cells resulting in abnormal cells that can become cancerous; however, the process is usually multifactorial and other conditions need to be met to develop cancer. ...Read more
The cell cycle: ...is activated in the immature "blast" cells of acute leukemia. This is not so much a defect, as it is also a normal attribute of immature blood cells. A major problem is the lack of maturation of these cells into normal non-dividing blood cells. Various transcription factors are mutated and these may cause increased proliferation. CLL is characterized by decreased apoptosis (cell death). ...Read more
Unknown: Most leukemias in adults and children do not have a specific etiology. Some leukemias in children can be linked to genetic abnormalities like down's syndrome, neurofibromatosis, bloom syndrome, and others. Ethnicity may play a role in all, hispanic children tend to have higer risk. High birth weight has been associated with higher risk though really this is unclear. Other factors are inconsistent. ...Read more
Most are due to muta: Mutations are common in all cancers. In Leukemia the very first mutation (Single mutation, causing cancer was discovered in Chronic Myelocytic Leukemia (CML). In most other Leukemias, there are multiple mutations present once we have learned how to search for them by Genomic profiling. ...Read more
?: Can you restate the question?Get a more detailed answer ›
Probably not.: Gcsf is given to raise the neutrophil count. Long term use usually is for severe chronic neutropenia with high risk of infection. While gcsf use has been reported in patients who have subsequently developed leukemia, so far such reports are only in people whose underlying disease already confers such a risk. There is no convincing evidence that gcsf increases that risk. ...Read more
My 12 year old's ANC has varied from 1341 down to 918, up to 2378 down to 805 over 6mths. If it were caused by leukemia would it go up and down?
No.: Leukemia will cause a low neutrophil count. And over the course of 6 months, leukemia will be very obvious. It would not only cause a low neutrophil count at that point. It would also cause low platelets (which causes bruising and bleeding) and low hemoglobin (which causes fatigue). ...Read more
Cll affects older white men more that other parts of the population and the cause is unknown in most cases. Exposure to certain herbicides and insecticides, including agent orange used during the vietnam war, have been linked to an increased risk. For more information
http://www. Mayoclinic. Com/health/chronic-lymphocytic-leukemia/ds00565/dsection=risk. ...Read more
Does high white cell count 15.4 and headaches on and off for 6 weeks always indicate leukemia? Or could there still be other causes?
Absolutely not: You can raise your white count to 20, 000 by spending a half hour swimming in cold water. If the cells are normally formed, and the rest of your blood count is reasonable, look around for some other cause; you may not find one. Look for a cause of headaches as well -- it may be as simple as needing new eyeglasses. Good luck. ...Read more
What are the causes of hematological malignancies? What is the leading cause for hematological malignancies, such as leukemia or lymphoma?
Hard to say...: Many times we don't know what causes leukemia or lymphoma, irrespective of type. The process is probably multifactorial and has a strong genetic component. In a small subset of cases exposure to various toxins like paint fumes, or to radiation, can also cause it, but this represents only a small percentage of patients. There is also an association with certain viruses (ebv, htlv). ...Read more
For a year now my B12 is at 2000, what could cause this? I keep reading about leukemia being linked with this, my dad just pasted away with leukemia?
CML and vit b12: While there is an association w/ elevated B12 levels and cml, we don't use vitamin B12 as a diagnostic test for cml. We go by other things like history, lab tests like CBC w/ diff, chemistry panel, physical exam and bone marrow biopsy. Yours could be elevated for many reasons including: diabetes, kidney disease, chf, and liver disease. Or that could just be what's normal for you. ...Read more
What could cause my sons white blood count to go to 65, 000? When my son was 7 years old, his white blood count was 65, 000. I heard normal was between 4, 800 and 10, 500. He was checked for leukemia and they said it did not look like it was leukemia.
Leukemia cause: We don't know for sure. Leukemia develops as the consequence of a series of genetic changes in blood cell offsprings. These changes alter normal growth and differentiation of the cells, resulting in an accumulation of abnormal, immature blood cells in the bone marrow and peripheral blood. Exposure to chemicals, radiation, tobacco, or chemotherapy, infection, etc have been associated with leukemia. ...Read more
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