Doctor insights on:
Can Men With Sickle Cell Disease Have Children
Yes.: Sickle cell disease must be inherited from both parents. So it depends on the mother of the child. If she has sickle cell - all of your children will have sickle cell. If she has sickle cell trait - there is a 50% chance your children will have sickle cell disease, and a 50% chance of your children having sickle cell trait. If she has no sickle cell - your children will have sickle cell trait. ...Read moreSee 1 more doctor answer
My husband and I are both carriers of sickle cell anemia. What are our chances of our children exhibiting this disease?
25%: If both of you have sickle cell trait then each of you has one normal beta hemoglobin gene (a) and one with the sickle cell mutation (s). Your children will inherit one beta globin gene from each of you for a total of two. Therefore for each child that you have, there is a 25% chance of sickle cell disease (ss), a 50% chance sickle cell trait (as), and 25% chance of normal hemoglobin (aa). ...Read moreSee 1 more doctor answer
YES: Be sure to let your obstetrician know you have sickle cell so you can be managed correctly. ...Read more
Yes, on average: Due to their disease, sickle cell disease children are immune-compromised, and it will be easier for them to get sick. That is why preventive antibiotics, vaccines, and flu-shots are so important for them. Any fever can represent a life-threatening emergency for them, so they must be extra careful to avoid ill people, wash their hands, avoid crowds, etc. ...Read moreSee 2 more doctor answers
Both carriers of the sickle-cell disease, would you take this risk or decide not to have children?
Personal choice: People decide on having kids for a variety of important considerations. The risk of sickle cell for 2 parents with trait is a firm 25% for any pregnancy, 50% for passing trait, 25% for normal. Ss disease is chronic, painful & frought with medical issues for a reduced life expectancy. That said, the choice remains personal. Donor sperm from a fertility center could avoid part of the worry. ...Read moreSee 1 more doctor answer
Proper care needed: As long as they are under proper medical attention there should be no problem. ...Read more
Does anybody know about how much of children or infants die of sickle cell disease before reaching puberty?
Small: With the advancement of preventive care, high utilization of hydroxyurea, and aggressive treatment for the complications associated with sickel cell disease, the life expectancy has greatly increased. According to recent reports, the median age at death for individuals with scd was 42 years for men and 48 years for women. ...Read moreSee 2 more doctor answers
Yes: In the treatment of sickle-cell disease, hydroxycarbamide increases the concentration of fetal hemoglobin. The precise mechanism of action is not yet clearbut it seems to activate of gammaglobin synthesis necessary for fetal hemoglobin. This stops the rapidly growing cells that turn into sickle cells. ...Read moreSee 2 more doctor answers
Yes: Hydre increases a type of hemoglobin called fetal hemoglobin in sicle cell patients and this prevents the sickle cells from breaking up easily. Hydrea (hydroxyurea) can reduce need for transfusions and patients may have less pain crises, chest sydrome and other complications. ...Read moreSee 1 more doctor answer
Good: With comprehensive sickle cell care, including newborn screening for the disease, childhood penicillin prophylaxis and receipt of new conjugated vaccines to decrease early death from infection, and ongoing screening for increased risk of stroke in childhood with resulting intervention to decrease risk of stroke, it is unusual for a child to die of sickle cell disease today. ...Read more
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