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Doctor insights on: Can I Take Benadryl And Zyrtec Together

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Is it safe to take Benadryl (diphenhydramine) and Zyrtec together? I was put on Zyrtec for an allergic reaction with steroids for swelling and it's keeping me awake.

Is it safe to take Benadryl (diphenhydramine) and Zyrtec together? I was put on Zyrtec for an allergic reaction with steroids for swelling and it's keeping me awake.

Zyrtec (cetirizine) not the cause: It's unlikely that Zyrtec is keeping you awake. If anything, it usually causes drowsiness. You can take one dose of Benadryl (diphenhydramine) with Zyrtec, although it's not usually recommended as it may cause dizziness or excess sedation. ...Read more

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Dr. John Chiu
1,037 doctors shared insights

Diphenhydramine (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


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Is it okay to take zyrtec with benadryl (diphenhydramine)?

Is it okay to take zyrtec with benadryl (diphenhydramine)?

Not really: These are both antihistamines. If both are needed then physician guidance should be sought. ...Read more

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Is it ok to take zyrtec after you've taken benadryl (diphenhydramine)?

Is it ok to take zyrtec after you've taken benadryl (diphenhydramine)?

Yes: Antihistamine is safe even with 4x the average daily dose. The major side effects would be dry mouth and drowsiness ( the latter much less common if one uses the non-sedating type). ...Read more

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Can you take zyrtec during day and Benadryl (diphenhydramine) at night?

Zyrtec and Benadryl (diphenhydramine): Hello. These two antihistamines taken together will probably cause sedation. As physicians, we often times double up on antihistamines in challenging cases but i usually use non-sedating antihistamines when I do this. There are other medications that may work better than this combination. Check with your doctor for other options. ...Read more

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Is safe if i take Benadryl (diphenhydramine) six hours after take zyrtec?

Is safe if i take Benadryl (diphenhydramine) six hours after take zyrtec?

Should be ok: While taking Benadryl (diphenhydramine) after zyrtec should be ok, it would be even better to know the underlying trigger to allow less medication usage. An allergist could determine why symptoms are not controlled with less medication. ...Read more

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Should i take Benadryl (diphenhydramine) until my zyrtec really kicks in?

Should i take Benadryl (diphenhydramine) until my zyrtec really kicks in?

Probably not helpful: Both drugs need to be absorbed by the GI system before they take effect to stop itching and sneezing (can take up to 1 hr). Benadryl (diphenhydramine) can dry up mucus (and make you sleepy), which zyrtec will not do at any time. If you have taken zyrtec for several days without relief from itching or sneezing, you may have something besides allergies (e.g. A cold) or need a different treatment. See your doctor. ...Read more

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Is it possible for you to take zyrtec and Benadryl (diphenhydramine) in the same day?

Is it possible for you to take zyrtec and Benadryl (diphenhydramine) in the same day?

Yes you can: You can take both medications at the same time providing that you follow the recommended otc doses. ...Read more

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Can you tell me is it ok to take zyrtec for daytime and Benadryl (diphenhydramine) for night?

Can you tell me is it ok to take zyrtec for daytime and Benadryl (diphenhydramine) for night?

Yes it is ok: Yes it is ok as long as you are using it for short period when your allergy symptoms are not controlled with zyrtec (cetirizine) and you are not able to sleep due to allergy symptoms. ...Read more

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Well, i took Benadryl (diphenhydramine) about 12 hours ago and i was wondering, may i take zyrtec?

Antihistamines: Yes you can, but you really should have some doctor guidance with your medications, because you did not mention what symptoms you are treating with the antihistamines and they may not be the ideal medication if you are not responding to one and need to add another. Talk to your doctor. ...Read more

Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


Dr. John Chiu
556 doctors shared insights

Cetirizine (Definition)

Ceftirizine is the generic name of an antihistamine previously marketed under the ...Read more