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Doctor insights on: Can Hydrea Be Used To Help Children With Sickle Cell Disease

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Can hydrea (hydroxyurea) be used to help children with sickle cell disease?

Can hydrea (hydroxyurea) be used to help children with sickle cell disease?

Yes: In the treatment of sickle-cell disease, hydroxycarbamide increases the concentration of fetal hemoglobin. The precise mechanism of action is not yet clearbut it seems to activate of gammaglobin synthesis necessary for fetal hemoglobin. This stops the rapidly growing cells that turn into sickle cells. ...Read more

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Dr. James Ball
348 doctors shared insights

Sickle Cell Disease (Definition)

This is a genetic disorder in which hemoglobin is abnormally made., more common in people of african descent. This abnormality causes red blood cells to become stiff and fall apart. This can cause very specific symptoms: pain, pneumonias, strokes, spleen problems, and many other problems. Some have mild disease, some ...Read more


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Could hydrea (hydroxyurea) possibly help children with sickle cell disease?

Yes: Hydre increases a type of hemoglobin called fetal hemoglobin in sicle cell patients and this prevents the sickle cells from breaking up easily. Hydrea (hydroxyurea) can reduce need for transfusions and patients may have less pain crises, chest sydrome and other complications. ...Read more

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What are the symptoms of sickle cell disease- hydroxyurea?

Well tolerated drug.: Hydrea (hydroxyurea) is a chemotherapy like drug that can help prevent painful crises in patients with sickle cell disease. It is well tolerated for the most part. There can be fatigue, mouth sores and loose stools. It will routinely lower the white blood cell count and platelets, but not to dangerous levels. Hemoglobin may actually improve. There is ? Of leukemia risk in other diseases, but not in scd. ...Read more

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Can we use hydroxyurea with sickle cell anemia patient?

HU in sickle cell: Certain patients with sickle cell can be helped by Hydroxyurea (hu). Initially, Hydroxyurea was thought to increase fetal hemoglobin levels (not carrying the sickle cell mutation), but more recently, hu has been shown to decrease high white blood cell counts which can lead to vaso-occlusive crises. Talk with your hematologist to see if hu is right for you. ...Read more

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What are the effects of a sickle cell patient using hydroxyurea in the long term?

What are the effects of a sickle cell patient using hydroxyurea in the long term?

Side Effects: There are some serious, but rare, side effects with hydroxyurea, including secondary leukemia, pulmonary fibrosis, pancreatitis, and peripheral neuropathy, or damage to the nerves. Discuss the benefits of decreasing the severity and length of the sickle cell attacks, and the risk of rare side effects as above. ...Read more

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I have sickle cell and I'm taking hydroxyurea, but I'm still having frequent crisis and hospital visits, does it not work for all patients?

Sometimes: It does not work for all patients, but it also does not work right away. Work with a hematologist to increase your dose of hydroxyurea to the maximum tolerated to increase your chances of increasing Fetal Hemoglobin [HbF] production (the goal of Hydrea is to make HbF instead of sickle hemoglobin) . Best wishes ...Read more

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What precautions should i take to decrease the episodes of crisis in sickle cell. I take folic acid & hydroxyurea as medication.

What precautions should i take to decrease the episodes of crisis in sickle cell. I take folic acid & hydroxyurea as medication.

Hydration: Besides taking your medication, the most important thing you can do to reduce sickle crisis is to keep yourself well hydrated. You need to be exceeding 80 oz of water daily. Even the least little dehydration can lead to increased viscosity (thickness) of your blood, and this in turn can lead to increased sickling and a full-blown crisis. Avoid dehydrating things like sun, alcohol and caffeine. ...Read more

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My husband and I are both carriers of sickle cell anemia. What are our chances of our children exhibiting this disease?

My husband and I are both carriers of sickle cell anemia. What are our chances of our children exhibiting this disease?

25%: If both of you have sickle cell trait then each of you has one normal beta hemoglobin gene (a) and one with the sickle cell mutation (s). Your children will inherit one beta globin gene from each of you for a total of two. Therefore for each child that you have, there is a 25% chance of sickle cell disease (ss), a 50% chance sickle cell trait (as), and 25% chance of normal hemoglobin (aa). ...Read more

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Dr. Margaret Shipp
232 doctors shared insights

Hydroxyurea (Definition)

Hydroxyurea ...Read more


Dr. Mark Pack
45 doctors shared insights

Hydrea (Definition)

Hydrea ...Read more