Doctor insights on:
Can Hydrea Be Used To Help Children With Sickle Cell Disease
Yes: In the treatment of sickle-cell disease, hydroxycarbamide increases the concentration of fetal hemoglobin. The precise mechanism of action is not yet clearbut it seems to activate of gammaglobin synthesis necessary for fetal hemoglobin. This stops the rapidly growing cells that turn into sickle cells. ...Read moreSee 2 more doctor answers
This is a genetic disorder in which hemoglobin is abnormally made., more common in people of african descent. This abnormality causes red blood cells to become stiff and fall apart. This can cause very specific symptoms: pain, pneumonias, strokes, spleen problems, and many other problems. Some have mild disease, some ...Read more
Yes: Hydre increases a type of hemoglobin called fetal hemoglobin in sicle cell patients and this prevents the sickle cells from breaking up easily. Hydrea can reduce need for transfusions and patients may have less pain crises, chest sydrome and other complications. ...Read moreSee 1 more doctor answer
I have sickle cell anemia and everyday iam constantly in pain and feel tired. I have been taking hydrea but is there anything else i could do?
My sympatrhy: Unfortunately no other treatments are yet available. ...Read more
Well tolerated drug.: Hydrea is a chemotherapy like drug that can help prevent painful crises in patients with sickle cell disease. It is well tolerated for the most part. There can be fatigue, mouth sores and loose stools. It will routinely lower the white blood cell count and platelets, but not to dangerous levels. Hemoglobin may actually improve. There is ? Of leukemia risk in other diseases, but not in scd. ...Read more
My husband and I are both carriers of sickle cell anemia. What are our chances of our children exhibiting this disease?
25%: If both of you have sickle cell trait then each of you has one normal beta hemoglobin gene (a) and one with the sickle cell mutation (s). Your children will inherit one beta globin gene from each of you for a total of two. Therefore for each child that you have, there is a 25% chance of sickle cell disease (ss), a 50% chance sickle cell trait (as), and 25% chance of normal hemoglobin (aa). ...Read moreSee 1 more doctor answer
Yes, on average: Due to their disease, sickle cell disease children are immune-compromised, and it will be easier for them to get sick. That is why preventive antibiotics, vaccines, and flu-shots are so important for them. Any fever can represent a life-threatening emergency for them, so they must be extra careful to avoid ill people, wash their hands, avoid crowds, etc. ...Read moreSee 2 more doctor answers
Both carriers of the sickle-cell disease, would you take this risk or decide not to have children?
Personal choice: People decide on having kids for a variety of important considerations. The risk of sickle cell for 2 parents with trait is a firm 25% for any pregnancy, 50% for passing trait, 25% for normal. Ss disease is chronic, painful & frought with medical issues for a reduced life expectancy. That said, the choice remains personal. Donor sperm from a fertility center could avoid part of the worry. ...Read moreSee 1 more doctor answer
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