Doctor insights on:
Can Hydrea Be Used To Help Children With Sickle Cell Disease
Yes: In the treatment of sickle-cell disease, hydroxycarbamide increases the concentration of fetal hemoglobin. The precise mechanism of action is not yet clearbut it seems to activate of gammaglobin synthesis necessary for fetal hemoglobin. This stops the rapidly growing cells that turn into sickle cells. ...Read moreSee 2 more doctor answers
Yes: Hydre increases a type of hemoglobin called fetal hemoglobin in sicle cell patients and this prevents the sickle cells from breaking up easily. Hydrea (hydroxyurea) can reduce need for transfusions and patients may have less pain crises, chest sydrome and other complications. ...Read moreSee 1 more doctor answer
I have sickle cell anemia and everyday iam constantly in pain and feel tired. I have been taking hydrea (hydroxyurea) but is there anything else i could do?
My sympatrhy: Unfortunately no other treatments are yet available. ...Read more
Well tolerated drug.: Hydrea (hydroxyurea) is a chemotherapy like drug that can help prevent painful crises in patients with sickle cell disease. It is well tolerated for the most part. There can be fatigue, mouth sores and loose stools. It will routinely lower the white blood cell count and platelets, but not to dangerous levels. Hemoglobin may actually improve. There is ? Of leukemia risk in other diseases, but not in scd. ...Read more
HU in sickle cell: Certain patients with sickle cell can be helped by Hydroxyurea (hu). Initially, Hydroxyurea was thought to increase fetal hemoglobin levels (not carrying the sickle cell mutation), but more recently, hu has been shown to decrease high white blood cell counts which can lead to vaso-occlusive crises. Talk with your hematologist to see if hu is right for you. ...Read moreSee 1 more doctor answer
Side Effects: There are some serious, but rare, side effects with hydroxyurea, including secondary leukemia, pulmonary fibrosis, pancreatitis, and peripheral neuropathy, or damage to the nerves. Discuss the benefits of decreasing the severity and length of the sickle cell attacks, and the risk of rare side effects as above. ...Read moreSee 1 more doctor answer
I have sickle cell and I'm taking hydroxyurea, but I'm still having frequent crisis and hospital visits, does it not work for all patients?
Sometimes: It does not work for all patients, but it also does not work right away. Work with a hematologist to increase your dose of hydroxyurea to the maximum tolerated to increase your chances of increasing Fetal Hemoglobin [HbF] production (the goal of Hydrea is to make HbF instead of sickle hemoglobin) . Best wishes ...Read more
What precautions should i take to decrease the episodes of crisis in sickle cell. I take folic acid & hydroxyurea as medication.
Hydration: Besides taking your medication, the most important thing you can do to reduce sickle crisis is to keep yourself well hydrated. You need to be exceeding 80 oz of water daily. Even the least little dehydration can lead to increased viscosity (thickness) of your blood, and this in turn can lead to increased sickling and a full-blown crisis. Avoid dehydrating things like sun, alcohol and caffeine. ...Read more
My husband and I are both carriers of sickle cell anemia. What are our chances of our children exhibiting this disease?
25%: If both of you have sickle cell trait then each of you has one normal beta hemoglobin gene (a) and one with the sickle cell mutation (s). Your children will inherit one beta globin gene from each of you for a total of two. Therefore for each child that you have, there is a 25% chance of sickle cell disease (ss), a 50% chance sickle cell trait (as), and 25% chance of normal hemoglobin (aa). ...Read moreSee 1 more doctor answer
Both carriers of the sickle-cell disease, would you take this risk or decide not to have children?
Personal choice: People decide on having kids for a variety of important considerations. The risk of sickle cell for 2 parents with trait is a firm 25% for any pregnancy, 50% for passing trait, 25% for normal. Ss disease is chronic, painful & frought with medical issues for a reduced life expectancy. That said, the choice remains personal. Donor sperm from a fertility center could avoid part of the worry. ...Read moreSee 1 more doctor answer
Does anybody know about how much of children or infants die of sickle cell disease before reaching puberty?
Small: With the advancement of preventive care, high utilization of hydroxyurea, and aggressive treatment for the complications associated with sickel cell disease, the life expectancy has greatly increased. According to recent reports, the median age at death for individuals with scd was 42 years for men and 48 years for women. ...Read moreSee 2 more doctor answers
YES: Be sure to let your obstetrician know you have sickle cell so you can be managed correctly. ...Read more
Proper care needed: As long as they are under proper medical attention there should be no problem. ...Read more
Good: With comprehensive sickle cell care, including newborn screening for the disease, childhood penicillin prophylaxis and receipt of new conjugated vaccines to decrease early death from infection, and ongoing screening for increased risk of stroke in childhood with resulting intervention to decrease risk of stroke, it is unusual for a child to die of sickle cell disease today. ...Read more
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