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Doctor insights on: Can Hydrea Be Used To Help Children With Sickle Cell Disease

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Can hydrea (hydroxyurea) be used to help children with sickle cell disease?

Can hydrea (hydroxyurea) be used to help children with sickle cell disease?

Yes: In the treatment of sickle-cell disease, hydroxycarbamide increases the concentration of fetal hemoglobin. The precise mechanism of action is not yet clearbut it seems to activate of gammaglobin synthesis necessary for fetal hemoglobin. This stops the rapidly growing cells that turn into sickle cells. ...Read more

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Dr. James Ball
356 doctors shared insights

Sickle Cell Disease (Definition)

An inherited blood disease causing red blood cells to be sickle (curved) shaped instead of round. It shortens life expectancy, and can result in bacterial infections, painful swelling of the hands and feet, fever, arthritis, leg ulcers, fatigue, anemia, eye damage, and ...Read more


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Could hydrea (hydroxyurea) possibly help children with sickle cell disease?

Could hydrea (hydroxyurea) possibly help children with sickle cell disease?

Yes: Hydre increases a type of hemoglobin called fetal hemoglobin in sicle cell patients and this prevents the sickle cells from breaking up easily. Hydrea (hydroxyurea) can reduce need for transfusions and patients may have less pain crises, chest sydrome and other complications. ...Read more

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How can gene therapy be used to cure someone with sickle cell?

How can gene therapy be used to cure someone with sickle cell?

Experimental now...: Researchers are looking into how gene therapy techniques might someday help patients with sickle cell disease. This has been done in animal models, but not humans. A bone marrow transplant can cure someone of sickle cell disease, but this procedure is not for everyone and carries very significant risks. ...Read more

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How does gene therapy be used to cure someone with sickle cell anemia?

How does gene therapy be used to cure someone with sickle cell anemia?

Replace gene: Gene therapy could be used to transfer a new replacement normal gene to cells producing red blood cells. That is how gene therapy would work however there are no approved gene therapy treatments for sickle cell anemia. ...Read more

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Can we use hydroxyurea with sickle cell anemia patient?

HU in sickle cell: Certain patients with sickle cell can be helped by Hydroxyurea (hu). Initially, Hydroxyurea was thought to increase fetal hemoglobin levels (not carrying the sickle cell mutation), but more recently, hu has been shown to decrease high white blood cell counts which can lead to vaso-occlusive crises. Talk with your hematologist to see if hu is right for you. ...Read more

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Wanted to know if adults with sickle cell disease can get splenic sequestration?

Wanted to know if adults with sickle cell disease can get splenic sequestration?

Yes: Splenic sequestration can occur in any sickle patient. Frequently the spleen auto-infarcts by age 3, but if patient has had prior transfusions, their spleen could regrow and could potentially be able to have sequestration. Please discuss with your doctor. ...Read more

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Help plz! Can sickle cell anemia be cured with gene therapy?

Help plz! Can sickle cell anemia be cured with gene therapy?

Not as far I know: This may be the future. But as of right now, I am not aware of gene therapy for sickle cell disease. The only cure for it at the moment is bone marrow transplant. ...Read more

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Can sickle cell be treated with desferal and vitamin c?

Can sickle cell be treated with desferal and vitamin c?

No, but---: Desferal is a chelating agent that binds iron. Usually sickle patients accumulate too much iron from blood transfusions and desferal will help in this complication. Vitamin c only helps to mobilize iron and does not actually treat sickle cell patients. Hope this information helps. ...Read more

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Can people with sickle cell disease have children?

YES: Be sure to let your obstetrician know you have sickle cell so you can be managed correctly. ...Read more

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Can men with sickle cell disease have children?

Can men with sickle cell disease have children?

Yes: Yes, it's possible, though many men with sickle cell have problems with infertility. ...Read more

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How can a patient as well as their family and friends be helped with coping with sickle cell anemia?

Start with the doc: Good question! if you are fortunate to have a comprehensive sickle cell program or organization, in your area, a phone call or visit to an event can help establish a connection. Some programs have dedicated social workers who work with family and friends to help with psychological and social aspects of the disease. If "coping" means specific problems, start with the hematologist and his staff. ...Read more

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How could 2 people without sickle-cell anemia to have a child with sickle-cell disease?

How could 2 people without sickle-cell anemia to have a child with sickle-cell disease?

Genetics: Sickle cell disease must be inherited from both parents. Sickle cell trait (1 sickle gene, 1 normal gene) is usually asymptomatic. 2 persons with sickle cell trait have a 1/4 chance of having a child with sickle cell disease, but the parents are often unaware that they have anything. ...Read more

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Can people with sickle cell safely take cold medicine?

Can people with sickle cell safely take cold medicine?

Maybe: If there are no other contraindications, then cold medicines should be ok. However - cold medications that incude acetaminophen/ ibuprophen will mask any fever and thus may hide a serious infection. Therefore, we sometimes ask families to not give these anti-fever medications if we are concerned about a serious infection. ...Read more

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What are cyanate and thiocyanate? Can they be used to treat sickle cell anemia?

What are cyanate and thiocyanate? Can they be used to treat sickle cell anemia?

Ask ur Hematologist: Dietary cyanate, from foods containing cyanide derivatives, has been used as a treatment for sickle- cell anemia. In the laboratory, cyanate and thiocyanate irreversibly inhibit sickling of red blood cells drawn from sickle cell anemia patients. However, the cyanate would have to be administered to the patient for a lifetime, as each new red blood cell created must be prevented from sickling. ...Read more

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Can you develop sickle cell anemia as an adult?

Can you develop sickle cell anemia as an adult?

Yes: You may not manifest sickle cell anemia until later in life. However, you don't develop or acquire sickle cell anemia at some point in life. It is genetic so you had it since birth. ...Read more

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Can men with sickle cell disease have healthy children?

Can men with sickle cell disease have healthy children?

Yes.: Sickle cell disease must be inherited from both parents. So it depends on the mother of the child. If she has sickle cell - all of your children will have sickle cell. If she has sickle cell trait - there is a 50% chance your children will have sickle cell disease, and a 50% chance of your children having sickle cell trait. If she has no sickle cell - your children will have sickle cell trait. ...Read more

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How do 2 people without sickle-cell anemia to have a child with sickle-cell disease?

How do 2 people without sickle-cell anemia to have a child with sickle-cell disease?

Yes: The defect of sickle cell anemia occurs when 2 sickle cell genes are passed to a newborn. Since each parent passes half their genes at conception & it takes 2 sickle genes to cause disease, one gene comes from each parent. Many parents carry this gene quietly, unknown to them because it doesn't make a single gene carrier sick. ...Read more

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Can prednisone 5mg be given to a sickle cell baby?

Can prednisone 5mg be given to a sickle cell baby?

Yes but: There may be better options, talk with the pediatric hematologist. ...Read more

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Dr. Margaret Shipp
235 doctors shared insights

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Dr. Corey Clay
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