Doctor insights on:
Can Hydrea Be Used To Help Children With Sickle Cell Disease
Yes: In the treatment of sickle-cell disease, hydroxycarbamide increases the concentration of fetal hemoglobin. The precise mechanism of action is not yet clearbut it seems to activate of gammaglobin synthesis necessary for fetal hemoglobin. This stops the rapidly growing cells that turn into sickle cells. ...Read moreSee 2 more doctor answers
An inherited blood disease causing red blood cells to be sickle (curved) shaped instead of round. It shortens life expectancy, and can result in bacterial infections, painful swelling of the hands and feet, fever, arthritis, leg ulcers, fatigue, anemia, eye damage, and ...Read more
Yes: Hydre increases a type of hemoglobin called fetal hemoglobin in sicle cell patients and this prevents the sickle cells from breaking up easily. Hydrea (hydroxyurea) can reduce need for transfusions and patients may have less pain crises, chest sydrome and other complications. ...Read moreSee 1 more doctor answer
Experimental now...: Researchers are looking into how gene therapy techniques might someday help patients with sickle cell disease. This has been done in animal models, but not humans. A bone marrow transplant can cure someone of sickle cell disease, but this procedure is not for everyone and carries very significant risks. ...Read moreSee 1 more doctor answer
HU in sickle cell: Certain patients with sickle cell can be helped by Hydroxyurea (hu). Initially, Hydroxyurea was thought to increase fetal hemoglobin levels (not carrying the sickle cell mutation), but more recently, hu has been shown to decrease high white blood cell counts which can lead to vaso-occlusive crises. Talk with your hematologist to see if hu is right for you. ...Read moreSee 1 more doctor answer
No, but---: Desferal is a chelating agent that binds iron. Usually sickle patients accumulate too much iron from blood transfusions and desferal will help in this complication. Vitamin c only helps to mobilize iron and does not actually treat sickle cell patients. Hope this information helps. ...Read more
YES: Be sure to let your obstetrician know you have sickle cell so you can be managed correctly. ...Read more
Proper care needed: As long as they are under proper medical attention there should be no problem. ...Read more
How can a patient as well as their family and friends be helped with coping with sickle cell anemia?
Start with the doc: Good question! if you are fortunate to have a comprehensive sickle cell program or organization, in your area, a phone call or visit to an event can help establish a connection. Some programs have dedicated social workers who work with family and friends to help with psychological and social aspects of the disease. If "coping" means specific problems, start with the hematologist and his staff. ...Read moreSee 1 more doctor answer
Genetics: Sickle cell disease must be inherited from both parents. Sickle cell trait (1 sickle gene, 1 normal gene) is usually asymptomatic. 2 persons with sickle cell trait have a 1/4 chance of having a child with sickle cell disease, but the parents are often unaware that they have anything. ...Read moreSee 2 more doctor answers
Maybe: If there are no other contraindications, then cold medicines should be ok. However - cold medications that incude acetaminophen/ ibuprophen will mask any fever and thus may hide a serious infection. Therefore, we sometimes ask families to not give these anti-fever medications if we are concerned about a serious infection. ...Read moreSee 1 more doctor answer
Ask ur Hematologist: Dietary cyanate, from foods containing cyanide derivatives, has been used as a treatment for sickle- cell anemia. In the laboratory, cyanate and thiocyanate irreversibly inhibit sickling of red blood cells drawn from sickle cell anemia patients. However, the cyanate would have to be administered to the patient for a lifetime, as each new red blood cell created must be prevented from sickling. ...Read moreSee 1 more doctor answer
Yes.: Sickle cell disease must be inherited from both parents. So it depends on the mother of the child. If she has sickle cell - all of your children will have sickle cell. If she has sickle cell trait - there is a 50% chance your children will have sickle cell disease, and a 50% chance of your children having sickle cell trait. If she has no sickle cell - your children will have sickle cell trait. ...Read moreSee 1 more doctor answer
Yes: The defect of sickle cell anemia occurs when 2 sickle cell genes are passed to a newborn. Since each parent passes half their genes at conception & it takes 2 sickle genes to cause disease, one gene comes from each parent. Many parents carry this gene quietly, unknown to them because it doesn't make a single gene carrier sick. ...Read moreSee 1 more doctor answer
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