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Doctor insights on: Can High Cortisol Raise Tsh

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Raised TSH (4,27), cortisol ((253,3 ng/ml) and prolactin levels (27,8 ng/ml). What could it mean?

Raised TSH (4,27), cortisol ((253,3 ng/ml) and prolactin levels (27,8 ng/ml). What could it mean?

What time of day?: Hi. They may be normal. The TSH could be a sign of early, subclinical hypothyroidism (getting TPO and thyroglobulin antibodies and free T4 may help the assessment). Due to diurnal variation, if the blood was drawn around 8 AM, the cortisol would be normal; very abnormal if drawn late at night. The prolactin, depending on the lab's normal range may be normal or slightly elevated. ...Read more

Dr. Quang Nguyen
943 doctors shared insights

Thyroid Stimulating Hormone (Definition)

A TSH test measures the amount of thyroid stimulating hormone (TSH) in your blood. TSH is produced by the pituitary gland and tells the thyroid gland to make and release the hormones thyroxine ...Read more


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Stress can increase tsh, but how high cortisol causes low TSH whereas stress causes high cortisol production.?

Stress can increase tsh, but how high cortisol causes low TSH whereas stress causes high cortisol production.?

Cortisol: This is a very complex system. In very basic terms cortisol is produced in response to stress and feeds back inhibiting production of itself (inhibiting crh and acth). Cortisol also inhibits TSH production (as well as growth hormone, estrogen, testosterone and lh production). Thus limiting the response to stress. It is though in chronic stress this feedback mechanism breaks down. ...Read more

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Tsh 3-8.75 last 3 years (fluctuating)-hypo sympt. Prolactin a bit high. Serum am cortisol norm but free urin. Low. Saliv cort 4pt flat low. Indications?

Tsh 3-8.75 last 3 years (fluctuating)-hypo sympt. Prolactin a bit high. Serum am cortisol norm but free urin. Low. Saliv cort 4pt flat low. Indications?

Hormone measurements: You have had a lot of hormones tested, but all seem more/less normal. If the TSH is high, the prolactin can often be slightly high too. If hypothyroid, treating with levothyroxine normalizes both. Adrenals sound fine, but the next test would be an acth stim test (but I don't think you need it if the am cort was really normal). Maybe your sx are not due to hormones at all. Something else? ...Read more

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My a.M. Cortisol serum is routinely 35+ (range 9-21), but low dose suppression test was normal. Tsh is slightly high, T3 (liothyronine) is elevated too. Causes?

My a.M. Cortisol serum is routinely 35+ (range 9-21), but low dose suppression test was normal. Tsh is slightly high, T3 (liothyronine) is elevated too. Causes?

Oral contraceptive: The most likely explanation for these findings is being on an oral contraceptive (yaz). This raises the cortisol binding protein level, making the total cortisol level look high, but the biologically active cortisol is normal. The same thing happens for thyroid hormone, including T3 (liothyronine) levels. If you have hashimotos and your TSH is high, you have mild hypothyroidism. ...Read more

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What causes high TSH 7.0 (although normal t3, (liothyronine)t4,pth) and low cortisol (1.0)? I'm being referred to an endo. I'm worried.

What causes high TSH 7.0 (although normal t3, (liothyronine)t4,pth) and low cortisol (1.0)? I'm being referred to an endo. I'm worried.

No worry: In early stages of hypothyroidism TSH is high when T3 (liothyronine) T4 may still be normal. Hypothyroidism is quite common and is easily treatable with an oral medication. However, you must follow your doctor's advice for additional tests and treatments. ...Read more

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Can this be hypopituitairism: high cortisol, highish prolactin, low HGH, lowish TSH, low LH and FSH in luteal phase, (lowish in follicular), low ADH (vasopressin)?

Can this be hypopituitairism: high cortisol, highish prolactin, low HGH, lowish TSH, low LH and FSH in luteal phase, (lowish in follicular), low ADH (vasopressin)?

Pituitary: It is difficult to diagnose hypopituitarism vased on labs you provided. High cortisol goes against hypopituitarism. High prolactin can lower FSH and LH. TSH normal range is 0.3-4. If pituitary dysfunction is suspected, we check Free T4, not TSH. I hope this answers your question ...Read more

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High TSH (7.12) accompanied by low cortisol (1.0). T4 and T3 (liothyronine) normal. What causes this? Mom had thyroid cancer. What tests should be done?

High TSH (7.12) accompanied by low cortisol (1.0). T4 and T3 (liothyronine) normal. What causes this? Mom had thyroid cancer. What tests should be done?

You need work-up: You should ask to be seen by an Endocrinolosit. Your question suggests that you may have low adrenal/thyroid function. Multiple gland "failure" is seen in a number of conditions. Certain blood/urine testing is indicated!
Good luck!
Hope this helps
Dr Z ...Read more

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TSH level: 0, T3/T4 normal, cortisol thru the roof, lymphocytes elevated, BP: 160/100 and waking @ 3am. MD saying it's hypothyroid. I disagree. Help?

TSH level: 0, T3/T4 normal, cortisol thru the roof, lymphocytes elevated, BP: 160/100 and waking @ 3am. MD saying it's hypothyroid. I disagree. Help?

Cushing syndrome: Cortisol thru the roof is Cushing syndrome until ruled out. Our job is to figure out why this is happening. Taking steroids can do this but shouldn't affect thyroid. I'd be more concerned about pituitary adenoma which can cause both Cushing AND central hypothyroidism (usually low TSH means hyperthyroidism) but in case of space occupying lesion in pituitary, it may put out ACTH in favor of TSH. ...Read more

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Would a raised TSH value, (thyriod fine) give you a wheat/celiac disease or wheat/celiac give you a high tsh?

Would a raised TSH value, (thyriod fine) give you a wheat/celiac disease or wheat/celiac give you a high tsh?

Unrelated: Thyroid stimulating hormone is not changed by celiac disease. Low thyroid might be causes by nan autoimmune problem, and celiac may be related to autoimmune problem, but they are different problems. ...Read more

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At 8am my acth was 80 (7 – 63 pg/ml), my TSH was 5.6 (0.4 – 4 uiu/ml), my cortisol was 535 (138 – 690 nmol/l) could this be related to my mood swings?

At 8am my acth was 80 (7 – 63 pg/ml), my TSH was 5.6 (0.4 – 4 uiu/ml), my cortisol was 535 (138 – 690 nmol/l) could this be related to my mood swings?

Cortisol mood: Your hormonal profile is normal in certain studies abnormal levels of cortisol can be seen with mood swings but no evidence that they are causal clearly very abnormal levels can cause mood changes. ...Read more

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My Ft3 and Ft4 numbers are at the very bottom of normals. My TSH has slightly risen. Is it normal to feel jittery when low? Cortisol tests needed?

Low T3 (liothyronine) and T4: It sounds as if your TSH is trying to improve your T3 (liothyronine) and T4. If that is so you most likely will need to start taking low doses of T4. Check with your doctor. ...Read more

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Male 33 — Thin build — TSH 5.610 — Cortisol 651 — Dr has written to blood department to advise on further testing — any idea what it could be please.

Subclinical hypothyr: Your TSH level is mildly elevated. This could indicate an early problem with your thyroid (subclinical hypothyroidism). It should be repeated with a free T4 level, and thyroid antibodies. The cortisol (nmol/L) is in the upper range of normal for a morning level. ...Read more

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Hi my TSH W/Reflex to FT4 is 4.54. What does this mean? also, my Cortisol is 26.8 what does this mean? Thank you Kindly.

Hi my TSH W/Reflex to FT4 is 4.54. What does this mean? also, my Cortisol is 26.8 what does this mean? Thank you Kindly.

Why testing?: More important is to ask why the blood tests were drawn and what other symptoms may be present. Also, lab values vary depending on the lab. In many labs, the values mentioned are normal. ...Read more

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On 75 mcg Synthroid for 8 months and TSH is .7, FT4 1.46, FT3 3.3 but still wake at 2am. Lower T4 dosage, wait it out or investigate cortisol issues?

On 75 mcg Synthroid for 8 months and TSH is .7, FT4 1.46, FT3 3.3 but still wake at 2am. Lower T4 dosage, wait it out or investigate cortisol issues?

NO: Your labs suggest you are on the right dose of synthroid. When you take it (should be in the AM) can affect sleep. If you are taking it correctly, I would recommend exploring other causes of your wakefulness ...Read more

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Help my TSH was 0.83 range is 0.3 – 5.6 my cortisol am fasting serum was 254 range is 185 – 624 honstly is there a chance for pituitary microadenoma?

Help my TSH was 0.83 range is 0.3 – 5.6 my cortisol am fasting serum was 254 range is 185 – 624 honstly is there a chance for pituitary microadenoma?

See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. The results you provided do not suggest the presence of pituitary lesion nor do the results rule it out. What makes you suspect that you have pituitary microadenoma? ...Read more

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On30mgarmourthyroid for 2months. Ft3+tsh normalized. However, still fatigued+gaining weight rapidly.Also, verylow cortisol. Do I need higher dose of armor?

NO/Consult Doctors: If your TSH and t3;t4 are normal you do not need to increase the dose. It may be related your other conditions like low cortisol and low ferritin
I suggest you discuss you concern with your doctor as to what is causing your fatigue and weight gain. ...Read more

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Acth=8 cortisol= 9 at 3 month pregnant. Postapartum tsh= .8 free t4= .8 as well. Hypo symptoms. What does this mean?

Acth=8 cortisol= 9 at 3 month pregnant. Postapartum tsh= .8 free t4= .8 as well. Hypo symptoms. What does this mean?

Results normal: All of these results are normal. Symptoms of low thyroid are very common in the population. Most people with those symptoms do not have a thyroid problem. Hormonal changes after pregnancy also cause many symptoms (not to mention fatigue associated with caring for an infant). If symptoms persist, you should see your doctor for further evaluation. ...Read more

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Cortisol is 651 — T4 Free 14.9 — TSH 5.610 — Male 33 could this be Addison Disease — Skin Pigmentation also — Male 33 — Thin build.

Cortisol is 651 — T4 Free 14.9 — TSH 5.610 — Male 33 could this be Addison Disease — Skin Pigmentation also — Male 33 — Thin build.

Doubt it: Hi. I am not familiar with the units you measure cortisol in Ireland, but if it the units I suspect (which would be 23 in the units we use), it would be very unlikely to be Addison's. You could have poor adrenal reserve, or the circumstances (e.g., stress) the cortisol 651 was drawn under could perhaps make one think yours should have been higher. With uncertainties, I can't be absolute. ...Read more

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Weak hungry shaky sweaty every 3-4hrs but GTT test, Sr Cr, cortisol,TSH are normal. I had B12 def, got corrected. I also feel ortho hypo at this time.

Weak hungry shaky sweaty every 3-4hrs but GTT test, Sr Cr, cortisol,TSH are normal. I had B12 def, got corrected. I also feel ortho hypo at this time.

Reactive Hypoglycemi: It could be reactive hypoglycemia which is not uncommon. It can be corrected if you reduce your intake of refined carbohydrates (Sweets and Sugars) and complement your meals with proteins. Most people need this done for breakfast and you can add Eggs and or nuts (Almonds and walnuts) to your daily menu. Let us know about your weight and also about your fasting blood sugar levels, then we can guid ...Read more

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Post partum hyperthyroiditis. Tsh is .009. My cortisol levels (through blood taken in the afternoon) was 28 (cut off 19). Cld this be from thyroid?

Post partum hyperthyroiditis. Tsh is .009. My cortisol levels (through blood taken in the afternoon) was 28 (cut off 19). Cld this be from thyroid?

Thyroiditis: Post partum thyroiditis is fairly common, often resolves on its own. There can be transient highT4 (and low TSH), then a transient low T4, and then resolution. Often no treatment, unless you're uncomfortable (beta blocker perhaps). Careful that this is not Graves disease, which can sometimes spring post-partum. The high cortisol is probably from stress. See your endocrinologist. ...Read more

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Morning cortisol level of 40 ug/dl, TSH is 4.4. On estrace (estradiol) (2mg) for low estrogen. 31 year old female. Is cortisol level cause for concern?

Morning cortisol level of 40 ug/dl, TSH is 4.4. On estrace (estradiol) (2mg) for low estrogen. 31 year old female. Is cortisol level cause for concern?

Elevated Cortisol: A cortisol of 40 is high and even though exogenous estrogen is known to slightly elevate serum cortisol levels, a value of 40 needs to be evaluated. Long term corrisol elevation is injurious to your health and may signify an underlying adrenal glandular condition, such as Cushing's syndrome. You should follow up with an endocrinologist soon. ...Read more

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Free T4 and T3 have normalized after 2 weeks on methimazole , but TSH is undetectable. normal cortisol and pituitary.Could TSH still normalize?

Free T4 and T3 have normalized after 2 weeks on methimazole , but TSH is undetectable. normal cortisol and pituitary.Could TSH still normalize?

Could: It is not feasible to give you the odds of a permanent remission. It would be prudent to follow your doctor's directions for medication and visits.
Wish you good health! - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex, if you have sex. ...Read more

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Cortisol 22mcg/dl and acth plasma 22 pg/ml morning (@8:30AM), TSH-4.26, Ft3- 2.34, Ft4-1.03, Insulin-11uiu/ml, avg glu-100. Fatigue, tired, F 28yrs?

Cortisol 22mcg/dl and acth plasma 22 pg/ml morning (@8:30AM), TSH-4.26, Ft3- 2.34, Ft4-1.03, Insulin-11uiu/ml, avg glu-100. Fatigue, tired, F 28yrs?

Mild or borderline: Underactive thyroid. Your doctor can prescribe you synthryoid pill to raise your free t4 up to 10 from 1.03. Your fatigue and tiredness may go away hopefully after that. Other values are not that bad tsh may be little elevated according to some labs. Ft3 is little high. Insulin and blood sugar ok. So, get the prescription for synthyroid pill from your doctor and start taking. ...Read more

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Is it bad result? & Why does my doktor tell me my blood tests are ok when:s-tsh 3,5. T4 9. T3 (liothyronine) 3,7. Ferrarin 13. S-cortisol 318. Levotyroxin 50mg/day.

Is it bad result? & Why does my doktor tell me my blood tests are ok when:s-tsh 3,5. T4 9. T3 (liothyronine) 3,7. Ferrarin 13. S-cortisol 318. Levotyroxin 50mg/day.

Hard to answer: Difficult to answer as different laboratories have different value ranges. Ur doctor is looking at the reference ranges likely and seeing that they may be within normal ranges per what the lab has resulted him or her with. ...Read more

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Very tired, mood swings & heavy irreg. Periods TSH 1.46. FT4 1. Antithytoid peroxidase 46.1. Cortisol 9. ACTH 9.9. DX hashi's no TX until hypo?

Hypothyroidism: Treatment of hypothyroidism is contingent upon the demonstration of the functional depression of the thyroid, which you do not seem to have. Perhaps your symptoms are due to something else? ...Read more