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Doctor insights on: Can Glutamic Acid Decarboxylase Antibody Be Reduced In The Body

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Can glutamic acid decarboxylase antibody be reduced in the body?

Can glutamic acid decarboxylase antibody be reduced in the body?

Glutamic acid decarb: Not that I am aware of. There are two forms of this enzyme coincidentally and the antibody is felt to be an autoimmune response to predict Insulin requirement in early type one diabetics. ...Read more

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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Is gout caused by an error in nucleic acid metabolism that leads to a buildup of uric acid in body fluids?

Is gout caused by an error in nucleic acid metabolism that leads to a buildup of uric acid in body fluids?

Uric acid: Most commonly, uric acid production is elevated from diet or its excretion is reduced from kidney impairment or diuretic rx. Enzyme defects can also elevate uric acid. ...Read more

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Can supplementing with acetyl L- Carnitine raise acetylcholine all over the body or does it only affect ACh levels in the brain?

Can supplementing with acetyl L- Carnitine raise acetylcholine all over the body or does it only affect ACh levels in the brain?

Probably neither: Unless you were severely deficient of it previously, supplementing with it is getting peed out in your urine. This supplement is like many on the market right now- they promise you all kinds of things they can't back up - and don't have to because they are classified as foods, not as medicines. So show me a good study that someone of normal diet and health actually increases brain levels with this ...Read more

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Can an increase in IgG + IgA proteins in the blood (serum) cause an overflow and therefore protein in the urine?

Can an increase in IgG + IgA proteins in the blood (serum) cause an overflow and therefore protein in the urine?

If kidney diseased..: Kidneys can leak protein if the kidneys are diseased. Proteinuria is a very sensitive predictor of development of progressive renal insufficiency, particularly when looking at high molecular weight proteins such as immunoglobulin g (igg), as predictors of chronic kidney disease progression. In some cases, mild proteinuria can occur without kidney disease. ...Read more

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If it inhibits Uric acid, which the body needs to a certain extent, will the body be deprived of the required amount of Uric acid? I gave heard of people on this drug loosing muscles. Is it true? Tks,

Waste: Uric acid is a waste product of protein metabolism in your body. It serves no purpose, nutritional or otherwise. If your body can not excreted properly or its overproduced/over accumulated, it can cause four. Meds are designed to excrete or keep you from accumulating it. Meds can have side effects if not properly taken, prescribed and/or monitored. ...Read more

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Does the pancreas treat olestra fatty acids similar to traditional fats/oils? Is the amount of enzymes produced the same in both cases? 

Does the pancreas treat olestra fatty acids similar to traditional fats/oils? Is the amount of enzymes produced the same in both cases? 

No.: Lipase is the pancreatic enzyme that splits (hydrolyzes) triglycerides in oils into fatty acids and monoglycerides. Lipase does not act on olestra, so olestra leaves the digestive tract undigested. This is why olestra has no usable calories. I do not know the answer to the question about degree of stimulation of lipase secretion by olestra vs. Other fats/oils. ...Read more

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Can amino acids be used by the body to make glucose fatty acids?

Can amino acids be used by the body to make glucose fatty acids?

Your body wilk: Break down anything and everything it can into basic building blocks and then metabolize them for calories and energy, store them away or use them to manufacture something like carbohydrates, proteins, fats or anything and everything else. There's nothing special about Amino Acids - they're just building blocks that will be broken down like everything else. ...Read more

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If AST enzymes were injected into the bloodstream, would glutamate levels in the brain lower?

If AST enzymes were injected into the bloodstream, would glutamate levels in the brain lower?

I don't think so: Not sure if ast will stimulate glutamate production in the brain- two different enzymes! ...Read more

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At which temperature (bodily and external) the MTHFR enzyme, a result of heterozygous C677T mutation, becomes thermolabile, i.e.inactive? Thank you.

At which temperature (bodily and external) the MTHFR enzyme, a result of heterozygous C677T mutation, becomes thermolabile, i.e.inactive? Thank you.

N/A: The mutation which causes dysfunction of the MTHFR enzyme is genetic - it doesn't happen because of a variation in body temperature. The rare disorder that this causes is characterized by a possibility of inappropriate clot formation, which can result in stroke or heart attack. However, a person proven to have this mutation may never actually experience such a thrombotic event. ...Read more

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How can the hemoglobin level in the body be increased?

How can  the hemoglobin level in the body be increased?

Depends: Depends on the reason that it is low. About the only thing that you can do on your own is dietary. If you have anemia because of low iron or vitamin deficiency, then improving your diet may help. ...Read more

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Is folic acid absorption can be interrupted in our body by what we eat( like iron can't be absorbed in presence of calcium) or nothing can affect it?

Is folic acid absorption can be interrupted in our body by what we eat( like iron can't be absorbed in presence of calcium) or nothing can affect it?

Few Simple Answers: Reality: the rate, speed, completeness may be altered some. None of the issues are as simple as implied by question as stated. The real high-tech is within each of us. Medicine, with scientific assistance, is about working to sort out some of the complexities within us. Basic chemistry principles, applied with fantastic complexity (called biochemistry, i.e. As implemented by all living organisms). ...Read more

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What food should be consumed in case the uric acid has increased?

What food should be consumed in case the uric acid has increased?

Uric acid diet: Tart cherry juice is effective; avoid organ meats; fatty meats and alcohol will elevate uric acid. Avoid these. Also, drink at least 3 liters fluid per day - this may enhance uric acid excretion - and if you incline diet successfully to mostly whole grain, fruit, and veggies, and nuts, using white fish and egg white for protein, then uric acid levels will come down. ...Read more

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Can you tell me if throughout digestion, hydrochloric acid (hcl) lowers the stomachs pH and this causes the enzyme?

Stomach vs.gut: The environment in stomach is acidic and stomach enzymes work better at low pH. The environment in intestine is alkaline and the pancreatic and intestinal enzymes work better at higher pH. ...Read more

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What steroid is given to some people who have high levels of protein in the urine.Does it help in reducing it.Can cretanine be reduced by any med.!!! ?

What steroid is given to some people who have high levels of protein in the urine.Does it help in reducing it.Can cretanine be reduced by any med.!!! ?

Prednisone ?: This is the drug of choice for proteinuria caused by the nephrotic syndrome. Creatinine is influenced by protein breakdown and kidney function as a whole, increasing fluid intake can drop creatinine on a short-term basis. Suggest you sit dow with nephrologist ...Read more

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What things, in the body, regulate glutamic acid? Glutamic acid decarboxylase? Glutamate receptors (nmda, ampa...Etc.)? What else is involved?

It's complicated...: There are some very exciting discoveries on the metabolism of glutamate... There are multiple pathways impacting on things such as gaba neurotransmitter, nitrogen clearance from the liver portal, etc... These pathways play vital roles in survival! please read this.... And email me your questions if you'd like! http://voh.Chem.Ucla.Edu/vohtar/spring04/classes/153ch/pdf/kelly%20and%20stanley.Pdf. ...Read more

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What is the role of lactic acid in muscle metabolism?

What is the role of lactic acid in muscle metabolism?

Lactic acidosis: Lactic acid is an end product of "anerobic metabolism". Normally cells use oxygen as a substrate for metabolism however if there is not enough oxygen available cells have an altered metabolic process where the end product is lactic acid Treatment is aimed at restoring normal perfusion. Individuals who exercise can generate lactate but it is rapidly removed due to a healthy cardiovascular system ...Read more

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Can you tell me if throughout digestion, hydrochloric acid (hcl) lowers the stomach's pH and this causes the enzyme?

Can you tell me if throughout digestion, hydrochloric acid (hcl) lowers the stomach's pH and this causes the enzyme?

Can you clarify?: The stomach ordinarily produces HCl lowering the pH and it is at this pH that the stomach enzymes work best. Further down, other enzymes are present that work at neutral pH. The stomach's acidity is largely about removing calcium from bits of bone. Does this answer your question? Best wishes. ...Read more

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Please explain why in diabetic patient the level of the enzyme pyrovate carboxylas are elevated?

Pyruvate carboxylase: This is a very unusual question and I'm wondering why you ask. PC is involved in gluconeogenesis, which is the conversion of lipid into glucose, which typically occurs during fasting and is often too high in diabetics. In a diabetic under poor control (eg. no insulin) the body senses absense of glucose ("starvation"), and gluconeogenesis increases to provided cells with more glucose. ...Read more

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Can glutamic acid decarboxylase antibody be reduced in the body?

Glutamic acid decarb: Not that I am aware of. There are two forms of this enzyme coincidentally and the antibody is felt to be an autoimmune response to predict Insulin requirement in early type one diabetics. ...Read more

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I have a glutamic acid decarboxylase antibody level of 3.4 u/ml. Is this anything to worry about? Labcorp says the result is "high".

I have a glutamic acid decarboxylase antibody level of 3.4 u/ml.  Is this anything to worry about?  Labcorp says the result is "high".

Why ordered?: This is supposed to be a marker for a kid who's likely to get juvenile onset diabetes. Are you perhaps a newly-diagnosed diabetic? There's talk that elevated antibodies sort-of predicts that diabetes in an adult will behave more like type i diabetes (require insulin) than type ii, but i'm not aware of a consensus on whether there is a treatment guideline. Read up & ask for a clear answer. ...Read more

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What things, in the body, regulate glutamic acid? Glutamic acid decarboxylase? Glutamate receptors (nmda, ampa...Etc.)? What else is involved?

It's complicated...: There are some very exciting discoveries on the metabolism of glutamate... There are multiple pathways impacting on things such as gaba neurotransmitter, nitrogen clearance from the liver portal, etc... These pathways play vital roles in survival! please read this.... And email me your questions if you'd like! http://voh.Chem.Ucla.Edu/vohtar/spring04/classes/153ch/pdf/kelly%20and%20stanley.Pdf. ...Read more

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In my recent blood test my glucose was 204. C-peptide was 0.37 and glutamic acid decarboxylase was >30.0. Also my hemoglobin A1c was 10.1?

In my recent blood test my glucose was 204. C-peptide was 0.37 and glutamic acid decarboxylase was >30.0.
Also my hemoglobin A1c was 10.1?

Type I diabetes.: With a hemoglobin A1C so high and I assume a high fasting glucose, unfortunately, it appears that you are diabetic. A high glutamic decarboxylase can mean anti-islet cell of the pancreas antibodies, but can also be elevated in other autoimmune conditions. A lower C-peptide and positive antibodies indicate Type I diabetes. If you are not on insulin yet, please seek help ASAP in the ER. ...Read more

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L-glutamic acid gives me severe dysesthesias. D-glutamic acid is worse. Could I have glutamate metabolism disorder or glutamate receptor antibodies?

L-glutamic acid gives me severe dysesthesias. D-glutamic acid is worse.  Could I have glutamate metabolism disorder or glutamate receptor antibodies?

Possibly but...: Good question without an easy answer. Glutamate is an "excitotoxin" that is not healthy for anyone but some people are more sensitive to it than others. There are a variety of uncommon glutamate metabolism disorders but you do not need to have one of these to be adversely affected by glutamate. Dysesthesias are not a known symptom of antibodies to glutamate receptors. See my comments:. ...Read more

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Why does l glutamic acid give me anxiety?

Why does l glutamic acid give me anxiety?

Excitatory: Glutamate molecule in the brain acts as an excitatory neurotransmitter, actually it is the most ubiquitous excitatory neurotransmitter in the brain.So it is possible this is how it leads to elevation of your anxiety. ...Read more

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Does glutamic acid good for als?

Does glutamic acid good for als?

Not at all: Quite the reverse, as many recommended meds are designed to inhibit glutamate responses. Regardless, the sole approved drug, Riluzole merely delays intubation, and is otherwise disappointing. Do not look for alternative therapies, they do not exist here in this very discouraging disorder. ...Read more

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If you have a glutamate metabolism disorder...& then you eat a food high in glutamic acid (meat, gluten, casein..Etc), what happens to you? Symptoms?

If you have a glutamate metabolism disorder...& then you eat a food high in glutamic acid (meat, gluten, casein..Etc), what happens to you? Symptoms?

A lot: Glutamate overall is an excitatory protein in the body. It stimulates the perception of taste and appetite. It also acts on the pancreas and liver. Our bodies need some but too much can cause a lot of different problems such as weight gain, diabetes, and neurotoxicity. In addition to avoiding high glutamate foods it is useful to consume extra carnitine (high in red meat) to counter the glutamate. ...Read more

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Dear doctors,I'm a 18 years old and my bro 15 years old, is we safe to serve with whey protein contains BCAAs and glutamic acid?

Dear doctors,I'm a 18 years old and my bro 15 years old, is we safe to serve with whey protein contains BCAAs and glutamic acid?

Safe in moderation: BCAA and other protein foods etc are generally safe if used in moderation and not extended periods (6 months). Read the label carefully, manufacturer info . Check with doctor if you experience any symptom of fTigue cramps , abdominal pain or urinary problem etc. ...Read more

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Cystine is depleted, while glycine and glutamic acid are highly elevated. Does that mean cysteine and subsequent glutathione deficiency? Any ideas? Ty

Cystine is depleted, while glycine and glutamic acid are highly elevated. Does that mean cysteine and subsequent glutathione deficiency? Any ideas? Ty

Not useful tests tod: Why are you wasting your money doing tests which have no significant medical relavance? Find a good internist who can help you attain better health than you are suffering from by going off track. ...Read more

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What would cause an intolerance to glutamic acid? Gad autoantibodies? Gad deficiency? Glutamate receptor autoantibodies(anti-nmda, anti-ampa)?

What would cause an intolerance to glutamic acid? Gad autoantibodies?  Gad deficiency?  Glutamate receptor autoantibodies(anti-nmda, anti-ampa)?

None of the above.: Msg - ubiquitous Amino Acid and major excitatory neurotransmitter in brain. Studied extensively. Does not cause allergy or intolerance except at high dose and only then in susceptible persons when given in large doses without food. See fda, j. Nutrition, food chem and toxicology, etc. ...Read more

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Glutamic acid high, myoglobin low, pain in legs, swollen lymphs, ck spiked over 6500 then norm. Headaches and passed out and lots more. What is this?

Glutamic acid high, myoglobin low, pain in legs, swollen lymphs, ck spiked over 6500 then norm. Headaches and passed out and lots more. What is this?

Baclofen side effect: High levels of glutamic acid, specially the glutamic acid dedecarboxylase may be associated with auto immumne disease and type one diabeties.Myoglobinis a muscle protein found in all muscle tissues including the heart, it helps to carry oxygen to the muscle.High levels of CPK indicates some muscle damage wich is in contradiction with low myoglobine.Baclofen may produce the symptoms you are complning. ...Read more

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Taking cyclosporine and cellcept (mycophenolate mofetil) due to liver transplant, can I take SUKROL ( glutamic acid ), my memory and concentration been decreased lately. ?

Taking cyclosporine and cellcept (mycophenolate mofetil) due to liver transplant, can I take SUKROL ( glutamic acid ), my memory and concentration been decreased lately.    ?

Don't take it.: Sukrol is an OTC supplement containing multiple ingredients, including glutamic acid, lecithin, and thiamine. It is impossible to predict whether any of these could have an interaction with your cyclosporine or CellCept (mycophenolate mofetil). Given the potentially dire consequences of an interaction, it is not worth it to take your chances with an unproven supplement. Good luck. ...Read more

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Diagnosed with chronic fatigue, fibromyalgia and Hashimoto’s. Recently referred to metabolic clinic. Plasma Amino Acid Results: LOW Glutamic Acid, LOW Proline, and NO Hydroxyproline. Any recommendations for further tests, tx or diagnodid? Thank you.

Diagnosed with chronic fatigue, fibromyalgia and Hashimoto’s. Recently referred to metabolic clinic. Plasma Amino Acid Results: LOW Glutamic Acid, LOW Proline, and NO Hydroxyproline. Any recommendations for further tests, tx or diagnodid? Thank you.

Additional tests: I'm not sure if these have already been done but you could also get an allergen panel and testing for gluten insensitivity/celiac disease. Metabolic testing is probably the last area that's unexplored, which is usually the case in the scenario you're describing. Hope this helps ...Read more

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What does it mean when your glutamate decarboxylase antibody test is positive?

What does it mean when your glutamate decarboxylase antibody test is positive?

Insulin in future?: Glutamic acid decarboxylase antibodies (gada) is the most important factor for prediction of Insulin therapy within 3 years in young adult diabetic patients not classified as type 1 diabetes on clinical grounds. Is is one of several pancreatic antibodies, but the best predictor of type one disease. ...Read more

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I get savage irrational rage & full-body dysesthesia when eating food high in aspartic, glutamic, & arachidonic acid. Why? Nmda receptor dysfunction?

I get savage irrational rage & full-body dysesthesia when eating food high in aspartic, glutamic, & arachidonic acid.  Why? Nmda receptor dysfunction?

MSG: We don't know. There is disagreement with such reactions but I have seen msg sensitivities and it can close to what you are describing. For more info go to http://inkchromatography.Wordpress.Com/2012/05/01/the-msg-files-part-iv-chinese-restaurant-syndrome-2/. ...Read more

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My daughter (7 yrs) blood test of antiglutamic acid decarboxylase (gad) is 54.000 iu/ml, what does it mean? Is there a way to stop its function?

My daughter  (7 yrs) blood test of antiglutamic acid decarboxylase (gad) is 54.000 iu/ml, what does it mean? Is there a way to stop its function?

Biochemistry: Gad is an enzyme that your body needs to make the neurotransmitter gaba. If this was drown in a child, i suspect that they are considering a spinocerebellar ataxia syndrome (sca) or hyperekplexia. These are complicated and rare disorders. Your child may need to a see a child neurologist with some expertise in neuromuscular disorders if anything unusual is being considered. ...Read more

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What are known bacterial species overproducing histidine decarboxylase or if more appropriate for asking - histamine, in a human body? Thank you.

What are known bacterial species overproducing histidine decarboxylase or if more appropriate for asking - histamine, in a human body? Thank you.

?: I do not think bacteria are inolved in any way of human histamine production, The human enzayme is controlled by allergen triggered phospherylation activation, not sure bacteria has such enzyme ...Read more

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Does 8 rabies shots in 4 months effect my immunity in opposite way and reduced or suppressed rabies antibody in my body instead of protection ?

Does 8 rabies shots in 4 months effect my immunity in opposite way and reduced  or suppressed rabies antibody in my body instead of protection ?

Not particularly: The cited treatment appears to be overkill. You are assumed to have protection from any rabies exposure after you complete the first series for a period of 2 years. Why they did this is not clear. It wouldn't "hurt" you or your immune system unless you had a bad reaction to the vaccine. The shots do hurt, so the downside I see if the pain & confusion involved. ...Read more