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Doctor insights on: Can Glutamic Acid Decarboxylase Antibody Be Reduced In The Body

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Dr. Stevan Cordas Dr. Cordas
Internal Medicine
53 years in practice
Philadelphia College of Osteopathic Medicine
1

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Can glutamic acid decarboxylase antibody be reduced in the body?

Can glutamic acid decarboxylase antibody be reduced in the body?

Glutamic acid decarb: Not that I am aware of. There are two forms of this enzyme coincidentally and the antibody is felt to be an autoimmune response to predict Insulin requirement in early type one diabetics. ...Read more

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


Dr. Ed Friedlander Dr. Friedlander
Pathology
40 years in practice
Northwestern University Feinberg School of Medicine
2

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I have a glutamic acid decarboxylase antibody level of 3.4 u/ml. Is this anything to worry about? Labcorp says the result is "high".

I have a glutamic acid decarboxylase antibody level of 3.4 u/ml.  Is this anything to worry about?  Labcorp says the result is "high".

Why ordered?: This is supposed to be a marker for a kid who's likely to get juvenile onset diabetes. Are you perhaps a newly-diagnosed diabetic? There's talk that elevated antibodies sort-of predicts that diabetes in an adult will behave more like type i diabetes (require insulin) than type ii, but i'm not aware of a consensus on whether there is a treatment guideline. Read up & ask for a clear answer. ...Read more

Dr. Joseph Shen Dr. Shen
Cardiology - Cardiac Electrophysiology
27 years in practice
Keck School of Medicine of University of Southern California
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What things, in the body, regulate glutamic acid? Glutamic acid decarboxylase? Glutamate receptors (nmda, ampa...Etc.)? What else is involved?

It's complicated...: There are some very exciting discoveries on the metabolism of glutamate... There are multiple pathways impacting on things such as gaba neurotransmitter, nitrogen clearance from the liver portal, etc... These pathways play vital roles in survival! please read this.... And email me your questions if you'd like! http://voh.Chem.Ucla.Edu/vohtar/spring04/classes/153ch/pdf/kelly%20and%20stanley.Pdf. ...Read more

Dr. Philip Kern Dr. Kern
Internal Medicine - Endocrinology
39 years in practice
New York Medical College
4
Dr. Carrie Cannon Dr. Cannon
Family Medicine
29 years in practice
Baylor College of Medicine
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In my recent blood test my glucose was 204. C-peptide was 0.37 and glutamic acid decarboxylase was >30.0. Also my hemoglobin A1c was 10.1?

In my recent blood test my glucose was 204. C-peptide was 0.37 and glutamic acid decarboxylase was >30.0.
Also my hemoglobin A1c was 10.1?

Type I diabetes.: With a hemoglobin A1C so high and I assume a high fasting glucose, unfortunately, it appears that you are diabetic. A high glutamic decarboxylase can mean anti-islet cell of the pancreas antibodies, but can also be elevated in other autoimmune conditions. A lower C-peptide and positive antibodies indicate Type I diabetes. If you are not on insulin yet, please seek help ASAP in the ER. ...Read more

Dr. Randy Baker Dr. Baker
Holistic Medicine
36 years in practice
University of Michigan Medical School
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L-glutamic acid gives me severe dysesthesias. D-glutamic acid is worse. Could I have glutamate metabolism disorder or glutamate receptor antibodies?

L-glutamic acid gives me severe dysesthesias. D-glutamic acid is worse.  Could I have glutamate metabolism disorder or glutamate receptor antibodies?

Possibly but...: Good question without an easy answer. Glutamate is an "excitotoxin" that is not healthy for anyone but some people are more sensitive to it than others. There are a variety of uncommon glutamate metabolism disorders but you do not need to have one of these to be adversely affected by glutamate. Dysesthesias are not a known symptom of antibodies to glutamate receptors. See my comments:. ...Read more

Dr. Imad Khreim Dr. Khreim
Psychiatry
35 years in practice
Faculty of Medicine, Jordan University of Science and Technology
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Why does l glutamic acid give me anxiety?

Why does l glutamic acid give me anxiety?

Excitatory: Glutamate molecule in the brain acts as an excitatory neurotransmitter, actually it is the most ubiquitous excitatory neurotransmitter in the brain.So it is possible this is how it leads to elevation of your anxiety. ...Read more

Dr. Bennett Machanic Dr. Machanic
Neurology
48 years in practice
Johns Hopkins University School of Medicine
8

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Does glutamic acid good for als?

Does glutamic acid good for als?

Not at all: Quite the reverse, as many recommended meds are designed to inhibit glutamate responses. Regardless, the sole approved drug, Riluzole merely delays intubation, and is otherwise disappointing. Do not look for alternative therapies, they do not exist here in this very discouraging disorder. ...Read more

Dr. Troy Ross Dr. Ross
Occupational Medicine
20 years in practice
Uniformed Services University of the Health Sciences F. Edward Hebert School of Medicine
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If you have a glutamate metabolism disorder...& then you eat a food high in glutamic acid (meat, gluten, casein..Etc), what happens to you? Symptoms?

If you have a glutamate metabolism disorder...& then you eat a food high in glutamic acid (meat, gluten, casein..Etc), what happens to you? Symptoms?

A lot: Glutamate overall is an excitatory protein in the body. It stimulates the perception of taste and appetite. It also acts on the pancreas and liver. Our bodies need some but too much can cause a lot of different problems such as weight gain, diabetes, and neurotoxicity. In addition to avoiding high glutamate foods it is useful to consume extra carnitine (high in red meat) to counter the glutamate. ...Read more

Dr. Jalal Zuberi Dr. Zuberi
Pediatrics
41 years in practice
Jawahar Lal Nehru Medical College
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Dear doctors,I'm a 18 years old and my bro 15 years old, is we safe to serve with whey protein contains BCAAs and glutamic acid?

Dear doctors,I'm a 18 years old and my bro 15 years old, is we safe to serve with whey protein contains BCAAs and glutamic acid?

Safe in moderation: BCAA and other protein foods etc are generally safe if used in moderation and not extended periods (6 months). Read the label carefully, manufacturer info . Check with doctor if you experience any symptom of fTigue cramps , abdominal pain or urinary problem etc. ...Read more

Dr. Sewa Legha Dr. Legha
Internal Medicine - Oncology
46 years in practice
Punjab University, Christian Medical College
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Cystine is depleted, while glycine and glutamic acid are highly elevated. Does that mean cysteine and subsequent glutathione deficiency? Any ideas? Ty

Cystine is depleted, while glycine and glutamic acid are highly elevated. Does that mean cysteine and subsequent glutathione deficiency? Any ideas? Ty

Not useful tests tod: Why are you wasting your money doing tests which have no significant medical relavance? Find a good internist who can help you attain better health than you are suffering from by going off track. ...Read more

Dr. Dan Fisher Dr. Fisher
Internal Medicine
23 years in practice
Uniformed Services University of the Health Sciences F. Edward Hebert School of Medicine
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What would cause an intolerance to glutamic acid? Gad autoantibodies? Gad deficiency? Glutamate receptor autoantibodies(anti-nmda, anti-ampa)?

What would cause an intolerance to glutamic acid? Gad autoantibodies?  Gad deficiency?  Glutamate receptor autoantibodies(anti-nmda, anti-ampa)?

None of the above.: Msg - ubiquitous Amino Acid and major excitatory neurotransmitter in brain. Studied extensively. Does not cause allergy or intolerance except at high dose and only then in susceptible persons when given in large doses without food. See fda, j. Nutrition, food chem and toxicology, etc. ...Read more

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Dr. Pietro Seni Dr. Seni
Orthopedic Surgery
43 years in practice
13

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Glutamic acid high, myoglobin low, pain in legs, swollen lymphs, ck spiked over 6500 then norm. Headaches and passed out and lots more. What is this?

Glutamic acid high, myoglobin low, pain in legs, swollen lymphs, ck spiked over 6500 then norm. Headaches and passed out and lots more. What is this?

Baclofen side effect: High levels of glutamic acid, specially the glutamic acid dedecarboxylase may be associated with auto immumne disease and type one diabeties.Myoglobinis a muscle protein found in all muscle tissues including the heart, it helps to carry oxygen to the muscle.High levels of CPK indicates some muscle damage wich is in contradiction with low myoglobine.Baclofen may produce the symptoms you are complning. ...Read more

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Dr. Andrew Seibert Dr. Seibert
Internal Medicine - Gastroenterology
31 years in practice
University of Louisville School of Medicine
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Taking cyclosporine and cellcept (mycophenolate mofetil) due to liver transplant, can I take SUKROL ( glutamic acid ), my memory and concentration been decreased lately. ?

Taking cyclosporine and cellcept (mycophenolate mofetil) due to liver transplant, can I take SUKROL ( glutamic acid ), my memory and concentration been decreased lately.    ?

Don't take it.: Sukrol is an OTC supplement containing multiple ingredients, including glutamic acid, lecithin, and thiamine. It is impossible to predict whether any of these could have an interaction with your cyclosporine or CellCept (mycophenolate mofetil). Given the potentially dire consequences of an interaction, it is not worth it to take your chances with an unproven supplement. Good luck. ...Read more

Dr. Thomas Namey Dr. Namey
Internal Medicine - Rheumatology
44 years in practice
Washington University School of Medicine
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What does it mean when your glutamate decarboxylase antibody test is positive?

What does it mean when your glutamate decarboxylase antibody test is positive?

Insulin in future?: Glutamic acid decarboxylase antibodies (gada) is the most important factor for prediction of Insulin therapy within 3 years in young adult diabetic patients not classified as type 1 diabetes on clinical grounds. Is is one of several pancreatic antibodies, but the best predictor of type one disease. ...Read more

Dr. Stevan Cordas Dr. Cordas
Internal Medicine
53 years in practice
Philadelphia College of Osteopathic Medicine
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I get savage irrational rage & full-body dysesthesia when eating food high in aspartic, glutamic, & arachidonic acid. Why? Nmda receptor dysfunction?

I get savage irrational rage & full-body dysesthesia when eating food high in aspartic, glutamic, & arachidonic acid.  Why? Nmda receptor dysfunction?

MSG: We don't know. There is disagreement with such reactions but I have seen msg sensitivities and it can close to what you are describing. For more info go to http://inkchromatography.Wordpress.Com/2012/05/01/the-msg-files-part-iv-chinese-restaurant-syndrome-2/. ...Read more

Dr. Matthew Kozminski Dr. Kozminski
Neurology
12 years in practice
Lake Erie College of Osteopathic Medicine
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My daughter (7 yrs) blood test of antiglutamic acid decarboxylase (gad) is 54.000 iu/ml, what does it mean? Is there a way to stop its function?

My daughter  (7 yrs) blood test of antiglutamic acid decarboxylase (gad) is 54.000 iu/ml, what does it mean? Is there a way to stop its function?

Biochemistry: Gad is an enzyme that your body needs to make the neurotransmitter gaba. If this was drown in a child, i suspect that they are considering a spinocerebellar ataxia syndrome (sca) or hyperekplexia. These are complicated and rare disorders. Your child may need to a see a child neurologist with some expertise in neuromuscular disorders if anything unusual is being considered. ...Read more

Dr. Jianjun Wu Dr. Wu
Pediatrics
33 years in practice
Shansi Medical College AKA Shanxi Medical College
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What are known bacterial species overproducing histidine decarboxylase or if more appropriate for asking - histamine, in a human body? Thank you.

What are known bacterial species overproducing histidine decarboxylase or if more appropriate for asking - histamine, in a human body? Thank you.

?: I do not think bacteria are inolved in any way of human histamine production, The human enzayme is controlled by allergen triggered phospherylation activation, not sure bacteria has such enzyme ...Read more

Dr. Gurmukh Singh Dr. Singh
Pathology
45 years in practice
University of Pune, Armed Forces Medical College
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What quantity of antibodies can your body have since they don't die for a long time?

What quantity of antibodies can your body have since they don't die for a long time?

Turn over rate: Antibodies do die out in 3-4 weeks. Body keeps making new ones. The normal level of all the antibodies is about 1.0gm/dl. ...Read more

Dr. Gurmukh Singh Dr. Singh
Pathology
45 years in practice
University of Pune, Armed Forces Medical College
20

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I am Rh positive i was told that my body developed antibodies. What does this mean?

What type of : Antibodies? We all make antibodies and these are essential for fighting infections. You may wish to discuss the matter with your doctor as it is not feasible to address the issue without knowing what antibodies you are concerned about. ...Read more