Doctor insights on:
Can Azithromycin Cause C Diff Infection
Possible, unlikely: Vancomycin is seldom taken orally, and when it is it can at least partially treat c. Difficile infection, although it isn't active against spores. When taken IV it is primarily excreted by the kidneys and little is likely to get into the distal colon unchanged. If it did it will not alter flora significantly and predispose to cl. Difficile overgrowth or toxin production by the vegetative form. ...Read more
Azithromycin (zithromax, azithrocin, zmax, azin) is an azalide, a subclass of macrolide antibiotics. Azithromycin is one of the world's best-selling antibiotics.[not in citation given (see discussion.)] it is derived from erythromycin, with a methyl-substituted nitrogen atom incorporated into the lactone ring, thus making ...Read more
I have had endocarditis twice got a c diff infection in a hospital can that infection cause endocarditis again?
How long does it take for a mild c diff infection caused by antibiotics to progress into a severe infection. How long until it's life threatening?
Depends: Most do not turn into life threatening infections. However, it does happen. It depends on the age, condition, risk factors that the patient has. ...Read more
Ibs patients not at any greater risk for complications from c. Diff.
C. Diff infection commonest after exposure to antibiotics (any, even for short periods, and up to 2-3 months after exposure), hospitalization, nursing homes, ibd, chemotherapy.
Can cause watery diarrheal illness, all the way to life threatening complications.
Any question, see your doc. Get stool testing. ...Read more
Is it possible to have a c diff infection so small that it only causes soft loose BMs every now & then?
There is no chronic c. Difficile infection. Untreated c. Difficile diarrhea can persist until effective treatment is given. The stool c. Difficile toxin test confirms the diagnosis.
30% of treated cases relapse and require repeat treatment. Future relapses become more likely and can require prolonged antibiotic treatment or fecal transplant therapy for cure. ...Read more
C.difficile needs Rx: C. Difficile is pathogenic in older children & adults (whose colonic microflora are altered by antibiotics, chemotherapy, salmonella/shigella). C. Diff causes pseudomembranous & other colitis, complicates inflammatory bowel disease, causes fulminant transmural extension, perforation with peritonitis, toxic megacolon. Florastor is otc probiotic that may help suppress c. Diff, but if sick get treated. ...Read more
Bacterial infection: Clostridium difficile (c. Diff) is a bacterium that infects the colon or large intestine. It can cause disease ranging from mild diarrhea to severe colitis with organ failure and death. It is associated with the use of antibiotics, which kill off healthy bacteria in your gut allowing space for c diff to grow. It is also associated with exposure to a hospital. Initial treatment is with antibiotics. ...Read more
I have early morning heartburn a lot. Not taking PPI drugs due to C-Diff infection.what can I do. I Raised my bed. Eat small meals and nothing spicy.
C Diff and PPI's: There is a moderate amount of evidence that C. difficile infection is more common in PPI users. You can try H2 blockers, such as Zantac, (ranitidine) but if your symptoms persist unabated, your physician will need to decide whether the symptoms you're having outweigh the increased risk of C. difficile infection. If your doctor agrees, try Zantac, (ranitidine) but you may need to have this discussion with him. Good luck. ...Read more
Hospital: The majority of c. Diff cases occur in the hospital with patients who are taking antibiotics to treat recent infections. Other risk factors include being over the age of 65, colon disease, being in a hospital or nursing home for an extended period, have a weak immune system, abdominal or gastrointestinal surgery, or previous history of c. Diff infections. ...Read more
Infection: Colon infection from clostridium difficile can cause fever, nausea, abdominal cramping pains, sometimes serious abdominal pain, diarrhea & dehydration. Some people can become very ill from this. Treated with specific antibiotics for this type of infection. Rarely requires surgery if severe & life threatening. ...Read more
C. Diff: C. Diff= clostridium dificile. This is a common organism that may inhabit the Gi tract. It causes disease when there is a shift in the flora and it produces a toxin that causes small ulcers and death of the surface cells. Traditionally, antibiotics that destroyed "good" flora as well as infection were blamed, but now many other things lead up to the change. ...Read more
Diarrhea & lots more: C. Difficile is pathogenic in older children & adults (whose colonic microflora are altered by antibiotics, chemotherapy, salmonella/shigella). C. Diff causes diarrhea w/pseudomembranous & other colitis, complicates inflammatory bowel disease, causes fulminant transmural extension, perforation with peritonitis, toxic megacolon. Treatment, & confirmation of post-treatment eradication, is recommended. ...Read more
Very unusual: Typically, antibiotic exposure is required for c diff to take hold in the colon. There are many reports of c diff occurring after just one dose of antibiotics! C diff occurring without any exposure to antibiotics may be theoretically possible in some situations, but is very rare and is unlikely to occur. ...Read more
C. difficile: Any antibiotic can potentially upset the balance of "good" bacteria & "bad" ones; clostridium difficile is one of the bad ones; it produces a toxin that causes severe diarrhea. Other antibiotics are required to get the c. Difficile back under control. Recently, it was reported that long-term use of proton pump inhibitors for gerd may facilitate c. Difficile. ...Read more
Unrelated factors: C diff: bacteria that normally lives in many peoples colons. Can be dormant (spores). When "peaceful co-existence" is unbalanced, c diff can overgrow, make toxin, cause watery diarrhea that can become severe; could get worse, even life threatening. Factors include antibiotic (ab) use (even 2mos previously), recent nursing home/ hosp adm, ibd, preg, contact with. Wash hands, no ab unless needed. Rx. ...Read more
Went to see mom on her birthday. She wasn't herself. Now on the phone she says she has c diff infection. Should I go back and see her doctor?
Sure, get info: If you don't have enough info about c. Diff in general, or your mom's case specifically, of course you should go back to her doctor (or at least a phone call) to find out what's what with her, what precautions you, she, and any other caregivers need to take to prevent this from becoming chronic or spreading to others. ...Read more
How likely am I to develop a c.diff infection if a household member is infected? He is being treated with Vancomycin. All washing hands like crazy.
No risk: None. If you are not on antibiotics and otherwise have a normal health situation you are not at risk. ...Read more
Long if not treated: C. Difficile can cause a prolonged severe colitis if it is not treated. If treated it usually starts to improve 3-4 days into the 10-14 day treatment course. Relapses occur in 25% of cases. These relapses require re-treatment and can continue to recur requiring prolonged pulse/taper vancomycin treatment and even fecal transplant therapy for cure. ...Read more
SIBO, documented?: Treatment is often offered empirically when sibo (small intestinal bacterial overgrowth) is suspected. However, symptoms recur when the antibiotics are gone. Is this due to underlying ibs, regrowth of bacteria (or resistant ones!), parasites, altered GI transit, or something else? Bifidobacter-containing probiotics may reduce gassiness, a xifaxan (rifaximin) trial may help, but evaluation is best pursued now. ...Read more
Infections are invasions of some other organism (fungus, bacteria, parasite) or viruses into places where they do not belong. For instance, we have normal gut bacteria that live within us without causing problems; however, when those penetrate the bowel wall and enter the bloodstream, ...Read more