Doctor insights on:
Can Alpha Thalassemia Be Dominant
Not quite: People normally have 4 Alpha globulin genes. A mutation in 1, 2, 3, or all 4 genes leads to the 4 levels of Alpha thalassemia. The genetics of the disorder is not all-or-none, not dominant-recessive. Instead, the more mutations, the worse the disease. One mutation = silent carrier (no symptoms), 2 muta. = Alpha trait (mild symptoms), 3 muta. = HGB h (moderate symptoms), 4 muta. = bart's (deaths). ...Read moreSee 1 more doctor answer
Conventional: As scientists investigated hemoglobin, the complicated compound in red blood cells that carries oxygen, they learned that it was made up of 5 parts; 4 of these are 2 copies each of 2 different proteins. They named these Alpha chains and beta chains. If you inherit a condition where the Alpha chains are produced in smaller amounts than normal, you have Alpha thalassemia. ...Read moreSee 1 more doctor answer
Hemoglobin problem: Alpha thal is caused by mutations that effect the production of a part of the hemoglobin molecule (Alpha chain). There are 4 genes involved in this production. Mutations can occur in 1 to 4 of these genes. The disease is more problematic the more genes are mutated. This disease is inherited from parents. ...Read more
4 alpha genes...: It is a bit complicated given that there are 4 Alpha chain genes and Alpha thalassemia can involve mutations in one, two (in two different ways) or three genes (mutations in four genes is usually not compatible with life). For excellent website, see: http://www.Stjude.Org/stjude/v/index.Jsp?Vgnextoid=d966885309c6f110vgnvcm1000001e0215acrcrd. ...Read moreSee 1 more doctor answer
Family history: Thalassemia is a genetic disease of the hemoglobin molecule and so only occurs through inheritance. A mutation in this gene is especially prevalent in persons of african, asian, middle eastern or mediterranean descent. Individuals with only one mutation of the gene will be asymptomatic, so genetic screening is necessary to precisely determine risk. ...Read moreSee 1 more doctor answer
None to severe/fatal: Alpha thalassemia signs and symptoms: silent carriers have no signs/symptoms; Alpha trait has mild anemia; HGB h (moderate) may have weakness, pallor, less growth, and need some transfusions; bart's disease (severe) is usually fatal before birth. ...Read moreSee 1 more doctor answer
None to severe/fatal: Alpha thalassemia signs and symptoms: silent carriers have no signs/symptoms (and live a normal life); Alpha trait has mild anemia (and generally live a normal life); HGB h (moderate) may have weakness, pallor, less growth, and need some transfusions; bart's disease (severe) is usually fatal before birth. ...Read moreSee 1 more doctor answer
Inherited defect: Our regular hemoglobin is composed of Alpha and beta chains that come together to form working hemaglobin. Alpha thalassemia trait occurs when a person inherits a defective Alpha chain gene from one parent & a normal Alpha chain gene from the other. This causes some reduction in Alpha chain production with resulting mild anemia. ...Read more
I am 24 and my height is 5'5" and weight 42kg. How can I gain weight. I have alpha thalassemia. Please help.
Yes: Your height may be within the range but you are just short. Your internist must put you on the growth chart which tells you if you are at the lower end of norms. Because of thalassemia, your internist will consult a hematologist and get complete details about the condition. He will then do some endocrine studies especially for pituitary and thyroid. He may get some x-rays of long bones ...Read more
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